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    Timeless timeless circadian regulator [ Rattus norvegicus (Norway rat) ]

    Gene ID: 83508, updated on 4-Jan-2025

    Summary

    Official Symbol
    Timelessprovided by RGD
    Official Full Name
    timeless circadian regulatorprovided by RGD
    Primary source
    RGD:620939
    See related
    EnsemblRapid:ENSRNOG00000031916 AllianceGenome:RGD:620939
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tim; rTIM; rTLP
    Summary
    The protein encoded by this gene is highly conserved and is involved in cell survival after damage or stress, increase in DNA polymerase epsilon activity, maintenance of telomere length, and epithelial cell morphogenesis. The encoded protein also plays a role in the circadian rhythm autoregulatory loop, interacting with the Period genes (Per1, Per2, and Per3) and others to downregulate activation of Per1 by Clock/Arntl. Changes in this gene or its expression may promote prostate cancer, lung cancer, breast cancer, and mental disorders. [provided by RefSeq, Feb 2014]
    Expression
    Biased expression in Thymus (RPKM 72.0), Spleen (RPKM 62.6) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Timeless in Genome Data Viewer
    Location:
    7q11
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (1239388..1263344)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (654804..678769)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (2643288..2667329)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene glutaminase 2 Neighboring gene SPRY domain containing 4 Neighboring gene major intrinsic protein of lens fiber Neighboring gene U6 spliceosomal RNA Neighboring gene apolipoprotein N Neighboring gene apolipoprotein F

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding  
    enables identical protein binding  
    enables identical protein binding  
    enables protein binding PubMed 
    Items 1 - 25 of 44
    Process Evidence Code Pubs
    involved_in DNA damage response  
    involved_in DNA damage response  
    involved_in DNA damage response  
    involved_in DNA repair  
    involved_in DNA replication checkpoint signaling  
    acts_upstream_of_or_within branching involved in ureteric bud morphogenesis PubMed 
    involved_in branching involved in ureteric bud morphogenesis PubMed 
    involved_in branching morphogenesis of an epithelial tube  
    acts_upstream_of_or_within branching morphogenesis of an epithelial tube  
    involved_in cell cycle phase transition  
    involved_in cell cycle phase transition  
    involved_in cell division  
    involved_in cellular response to bleomycin  
    involved_in cellular response to bleomycin  
    involved_in cellular response to bleomycin  
    involved_in cellular response to cisplatin  
    involved_in cellular response to cisplatin  
    involved_in cellular response to cisplatin  
    involved_in cellular response to hydroxyurea  
    involved_in cellular response to hydroxyurea  
    involved_in cellular response to hydroxyurea  
    involved_in circadian rhythm  
    involved_in circadian rhythm  
    involved_in circadian rhythm  
    involved_in kidney development PubMed 
    involved_in lung development  
    acts_upstream_of_or_within lung development  
    involved_in morphogenesis of an epithelium PubMed 
    involved_in morphogenesis of an epithelium  
    involved_in negative regulation of DNA-templated transcription  
    involved_in negative regulation of DNA-templated transcription  
    involved_in negative regulation of DNA-templated transcription  
    involved_in positive regulation of circadian rhythm PubMed 
    involved_in positive regulation of double-strand break repair  
    involved_in positive regulation of double-strand break repair  
    involved_in positive regulation of double-strand break repair via homologous recombination  
    involved_in positive regulation of double-strand break repair via homologous recombination  
    involved_in positive regulation of double-strand break repair via homologous recombination  
    NOT involved_in regulation of cell population proliferation  
    involved_in regulation of circadian rhythm  
    involved_in regulation of circadian rhythm  
    involved_in regulation of circadian rhythm  
    involved_in replication fork arrest  
    involved_in rhythmic process  
    Items 1 - 25 of 44
    Component Evidence Code Pubs
    located_in chromatin  
    located_in chromatin  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus PubMed 
    located_in nucleus  
    located_in nucleus  
    part_of replication fork protection complex  
    located_in site of double-strand break  
    located_in site of double-strand break  
    located_in site of double-strand break  

    General protein information

    Preferred Names
    protein timeless homolog
    Names
    timeless circadian clock
    timeless homolog
    timeless-like protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031340.2NP_112630.2  protein timeless homolog

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      Q9Z2Y1
      Related
      ENSRNOP00000070516.3, ENSRNOT00000083899.3
      Conserved Domains (2) summary
      pfam04821
      Location:25284
      TIMELESS; Timeless protein
      pfam05029
      Location:10051091
      TIMELESS_C; Timeless protein C terminal region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      1239388..1263344
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039079948.2XP_038935876.1  protein timeless homolog isoform X1

      UniProtKB/Swiss-Prot
      Q9Z2Y1
      Conserved Domains (2) summary
      pfam04821
      Location:25284
      TIMELESS; Timeless protein
      pfam05029
      Location:10051091
      TIMELESS_C; Timeless protein C terminal region
    2. XM_039079950.2XP_038935878.1  protein timeless homolog isoform X2

      UniProtKB/Swiss-Prot
      Q9Z2Y1
      UniProtKB/TrEMBL
      A0A0G2JY47
      Conserved Domains (2) summary
      pfam04821
      Location:25284
      TIMELESS; Timeless protein
      pfam05029
      Location:10051091
      TIMELESS_C; Timeless protein C terminal region
    3. XM_039079954.2XP_038935882.1  protein timeless homolog isoform X6

      UniProtKB/TrEMBL
      A0A8I6GBL8
      Conserved Domains (2) summary
      pfam04821
      Location:25284
      TIMELESS; Timeless protein
      pfam05029
      Location:9461032
      TIMELESS_C; Timeless protein C terminal region
    4. XM_063264310.1XP_063120380.1  protein timeless homolog isoform X6

      UniProtKB/TrEMBL
      A0A8I6GBL8
      Related
      ENSRNOP00000085093.2, ENSRNOT00000116339.2
    5. XM_063264311.1XP_063120381.1  protein timeless homolog isoform X7

      UniProtKB/TrEMBL
      A0A8I6GBL8
    6. XM_039079949.2XP_038935877.1  protein timeless homolog isoform X1

      UniProtKB/Swiss-Prot
      Q9Z2Y1
      Conserved Domains (2) summary
      pfam04821
      Location:25284
      TIMELESS; Timeless protein
      pfam05029
      Location:10051091
      TIMELESS_C; Timeless protein C terminal region
    7. XM_063264306.1XP_063120376.1  protein timeless homolog isoform X3

      UniProtKB/Swiss-Prot
      Q9Z2Y1
    8. XM_063264307.1XP_063120377.1  protein timeless homolog isoform X4

      UniProtKB/Swiss-Prot
      Q9Z2Y1
    9. XM_063264308.1XP_063120378.1  protein timeless homolog isoform X5

      UniProtKB/Swiss-Prot
      Q9Z2Y1
    10. XM_063264304.1XP_063120374.1  protein timeless homolog isoform X1

      UniProtKB/Swiss-Prot
      Q9Z2Y1
    11. XM_063264305.1XP_063120375.1  protein timeless homolog isoform X2

      UniProtKB/Swiss-Prot
      Q9Z2Y1
      UniProtKB/TrEMBL
      A0A0G2JY47
    12. XM_063264309.1XP_063120379.1  protein timeless homolog isoform X6

      UniProtKB/TrEMBL
      A0A8I6GBL8
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