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    Cyp4f5 cytochrome P450, family 4, subfamily f, polypeptide 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 286905, updated on 27-Dec-2024

    Summary

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    Symbol
    Cyp4f5provided by RGD
    Full Name
    cytochrome P450, family 4, subfamily f, polypeptide 5provided by RGD
    Primary source
    RGD:708364
    See related
    EnsemblRapid:ENSRNOG00000042496 AllianceGenome:RGD:708364
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable heme binding activity; iron ion binding activity; and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Involved in leukotriene metabolic process and response to 3-methylcholanthrene. Predicted to be located in endoplasmic reticulum membrane. Biomarker of congestive heart failure and hypertrophic cardiomyopathy. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 37.1), Thymus (RPKM 33.2) and 9 other tissues See more
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    Genomic context

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    See Cyp4f5 in Genome Data Viewer
    Location:
    7q11
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (12194567..12209495)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (11544040..11558982)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (14559806..14574345)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479822 Neighboring gene cytochrome P450, family 4, subfamily f, polypeptide 39 Neighboring gene cytochrome P450, family 4, subfamily f, polypeptide 17 Neighboring gene cytochrome P450, family 4, subfamily f, polypeptide 37 Neighboring gene heterogeneous nuclear ribonucleoprotein A1-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Leukotriene B4 omega-side chain hydroxylation by CYP4F5 and CYP4F6. Bylund J, et al. Arch Biochem Biophys, 2003 Apr 1. PMID 12646265
    2. cDNA cloning of three new forms of rat brain cytochrome P450 belonging to the CYP4F subfamily. Kawashima H, et al. Biochem Biophys Res Commun, 1995 Dec 26. PMID 8554568
    3. Renal localization, expression, and developmental regulation of P450 4F cytochromes in three substrains of spontaneously hypertensive rats. Kalsotra A, et al. Biochem Biophys Res Commun, 2005 Dec 9. PMID 16182239
    4. Regulation of neuronal type genes in congestive heart failure rats. Andersson KB, et al. Acta Physiol (Oxf), 2006 Jan. PMID 16497176
    5. 3-methylcholanthrene and benzo(a)pyrene modulate cardiac cytochrome P450 gene expression and arachidonic acid metabolism in male Sprague Dawley rats. Aboutabl ME, et al. Br J Pharmacol, 2009 Dec. PMID 19889059, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in leukotriene metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to 3-methylcholanthrene IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in small molecule metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450 4F5
    Names
    CYPIVF5
    cytochrome P450 4F5-like
    NP_775147.1
    XP_038934451.1
    XP_038934453.1
    XP_038934455.1
    XP_063119147.1
    XP_063119148.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173124.1 → NP_775147.1  cytochrome P450 4F5

      See identical proteins and their annotated locations for NP_775147.1

      Status: PROVISIONAL

      Source sequence(s)
      U39207
      UniProtKB/Swiss-Prot
      P51870
      UniProtKB/TrEMBL
      Q9EQ70
      Related
      ENSRNOP00000076271.3, ENSRNOT00000093545.3
      Conserved Domains (1) summary
      pfam00067
      Location:52 → 516
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      12194567..12209495
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078523.2 → XP_038934451.1  cytochrome P450 4F5 isoform X1

      UniProtKB/TrEMBL
      A2VD07, A6K954, F7FNW8, Q9EQ70
      Conserved Domains (1) summary
      cd20679
      Location:74 → 517
      CYP4F; cytochrome P450 family 4, subfamily F

    2. XM_063263077.1 → XP_063119147.1  cytochrome P450 4F5 isoform X2

      UniProtKB/TrEMBL
      Q9EQ70
      Related
      ENSRNOP00000007428.3, ENSRNOT00000007428.8

    3. XM_063263078.1 → XP_063119148.1  cytochrome P450 4F5 isoform X3

      UniProtKB/TrEMBL
      A0A1W2Q6H4

    4. XM_039078525.2 → XP_038934453.1  cytochrome P450 4F5 isoform X3

      UniProtKB/TrEMBL
      A0A1W2Q6H4
      Conserved Domains (1) summary
      cl41757
      Location:1 → 344
      cytochrome_P450; cytochrome P450 (CYP) superfamily

    5. XM_039078527.2 → XP_038934455.1  cytochrome P450 4F5 isoform X4

      UniProtKB/TrEMBL
      A0A1W2Q6H4
      Conserved Domains (1) summary
      cl41757
      Location:10 → 320
      cytochrome_P450; cytochrome P450 (CYP) superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P51870.1 GenPept UniProtKB/Swiss-Prot:P51870

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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