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    P4ha1 prolyl 4-hydroxylase subunit alpha 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64475, updated on 9-Dec-2024

    Summary

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    Official Symbol
    P4ha1provided by RGD
    Official Full Name
    prolyl 4-hydroxylase subunit alpha 1provided by RGD
    Primary source
    RGD:621000
    See related
    EnsemblRapid:ENSRNOG00000050655 AllianceGenome:RGD:621000
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    PHalphaI
    Summary
    Predicted to enable identical protein binding activity and procollagen-proline 4-dioxygenase activity. Predicted to be involved in collagen fibril organization. Predicted to act upstream of or within peptidyl-proline hydroxylation to 4-hydroxy-L-proline. Predicted to be located in mitochondrion. Predicted to be part of procollagen-proline 4-dioxygenase complex. Predicted to be active in endoplasmic reticulum. Orthologous to human P4HA1 (prolyl 4-hydroxylase subunit alpha 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 265.1), Lung (RPKM 252.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See P4ha1 in Genome Data Viewer
    Location:
    20q11
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (27784696..27895785)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (27302046..27352098)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (28920616..28972576)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene septin 10 Neighboring gene sosondowah ankyrin repeat domain family member C Neighboring gene small nuclear ribonucleoprotein D2-like Neighboring gene U7 small nuclear RNA Neighboring gene phospholipase A2, group XIIB Neighboring gene oncoprotein induced transcript 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of the 5'-flanking region of the rat P4Halpha gene encoding the prolyl 4-hydroxylase alpha(I) subunit. Takahashi S, et al. Biochim Biophys Acta, 2002 Apr 12. PMID 11997102
    2. Hypoxic induction of prolyl 4-hydroxylase alpha (I) in cultured cells. Takahashi Y, et al. J Biol Chem, 2000 May 12. PMID 10799490
    3. The complete cDNA derived sequence of the rat prolyl 4-hydroxylase alpha subunit. Hopkinson I, et al. Gene, 1994 Nov 18. PMID 7959029
    4. The structural motifs for substrate binding and dimerization of the α subunit of collagen prolyl 4-hydroxylase. Anantharajan J, et al. Structure, 2013 Dec 3. PMID 24207127
    5. Loss of assembly of the main basement membrane collagen, type IV, but not fibril-forming collagens and embryonic death in collagen prolyl 4-hydroxylase I null mice. Holster T, et al. J Biol Chem, 2007 Jan 26. PMID 17135260

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables L-ascorbic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables procollagen-proline 4-dioxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables procollagen-proline 4-dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables procollagen-proline 4-dioxygenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables procollagen-proline 4-dioxygenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables procollagen-proline 4-dioxygenase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in collagen fibril organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within collagen fibril organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within peptidyl-proline hydroxylation to 4-hydroxy-L-proline ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-proline hydroxylation to 4-hydroxy-L-proline TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum lumen IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of procollagen-proline 4-dioxygenase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    prolyl 4-hydroxylase subunit alpha-1
    Names
    4-PH alpha-1
    procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide
    procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I
    procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1
    prolyl 4-hydroxylase alpha subunit
    prolyl 4-hydroxylase, alpha polypeptide I
    NP_742059.2
    XP_006256486.1
    XP_006256487.1
    XP_063135563.1
    XP_063135564.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172062.3 → NP_742059.2  prolyl 4-hydroxylase subunit alpha-1 precursor

      See identical proteins and their annotated locations for NP_742059.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/Swiss-Prot
      P54001, Q6AZ74
      UniProtKB/TrEMBL
      A0A8L2QWJ8, A6K3U6
      Related
      ENSRNOP00000064405.3, ENSRNOT00000070897.3
      Conserved Domains (2) summary
      smart00702
      Location:345 → 518
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:25 → 112
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      27784696..27895785
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279494.1 → XP_063135564.1  prolyl 4-hydroxylase subunit alpha-1 isoform X2

    2. XM_006256425.4 → XP_006256487.1  prolyl 4-hydroxylase subunit alpha-1 isoform X1

      See identical proteins and their annotated locations for XP_006256487.1

      UniProtKB/TrEMBL
      A0A8I6ASU1, A0A8L2QWJ8, A6K3U5
      Related
      ENSRNOP00000096608.1, ENSRNOT00000117090.2
      Conserved Domains (2) summary
      smart00702
      Location:345 → 518
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:25 → 112
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    3. XM_063279493.1 → XP_063135563.1  prolyl 4-hydroxylase subunit alpha-1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ASU1, A0A8L2QWJ8, A6K3U5

    4. XM_006256424.5 → XP_006256486.1  prolyl 4-hydroxylase subunit alpha-1 isoform X2

      See identical proteins and their annotated locations for XP_006256486.1

      UniProtKB/Swiss-Prot
      P54001, Q6AZ74
      UniProtKB/TrEMBL
      A0A8L2QWJ8, A6K3U6
      Conserved Domains (2) summary
      smart00702
      Location:345 → 518
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:25 → 112
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P54001.2 GenPept UniProtKB/Swiss-Prot:P54001

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