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    SWEET12 bidirectional sugar transporter SWEET12-like protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 832431, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SWEET12
    Official Full Name
    bidirectional sugar transporter SWEET12-like protein
    Primary source
    TAIR:AT5G23660
    Locus tag
    AT5G23660
    See related
    Araport:AT5G23660
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtSWEET12; homolog of Medicago truncatula MTN3; MQM1.8; MQM1_8; MTN3
    Summary
    Encodes a member of the SWEET sucrose efflux transporter family proteins.
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    Genomic context

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    See SWEET12 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    6
    Sequence:
    Chromosome: 5; NC_003076.8 (7971647..7973995, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene phosphate deficiency response 2 Neighboring gene Homeodomain-like transcriptional regulator Neighboring gene ncRNA Neighboring gene tRNA-Gln

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Two evolutionarily duplicated domains individually and post-transcriptionally control SWEET expression for phloem transport. Zhang C, et al. New Phytol, 2021 Nov. PMID 34431115
    2. Disruption of the Sugar Transporters AtSWEET11 and AtSWEET12 Affects Vascular Development and Freezing Tolerance in Arabidopsis. Le Hir R, et al. Mol Plant, 2015 Nov 2. PMID 26358680
    3. A cascade of sequentially expressed sucrose transporters in the seed coat and endosperm provides nutrition for the Arabidopsis embryo. Chen LQ, et al. Plant Cell, 2015 Mar. PMID 25794936, Free PMC Article
    4. Water Deficit Enhances C Export to the Roots in Arabidopsis thaliana Plants with Contribution of Sucrose Transporters in Both Shoot and Roots. Durand M, et al. Plant Physiol, 2016 Mar. PMID 26802041, Free PMC Article
    5. Sucrose efflux mediated by SWEET proteins as a key step for phloem transport. Chen LQ, et al. Science, 2012 Jan 13. PMID 22157085

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Two evolutionarily duplicated domains individually and post-transcriptionally control SWEET expression for phloem transport.
      Title: Two evolutionarily duplicated domains individually and post-transcriptionally control SWEET expression for phloem transport.
    2. Data indicate that the transcript levels of sucrose transporters AtSUC2, AtSWEET11, AtSWEET12 and AtSWEET15 were significantly higher in stressed roots.
      Title: Water Deficit Enhances C Export to the Roots in Arabidopsis thaliana Plants with Contribution of Sucrose Transporters in Both Shoot and Roots.
    3. in addition to their contribution to phloem loading in source leaves, the AtSWEET11 and AtSWEET12 proteins act as sugar exporters that deliver carbon-containing skeletons to developing xylem cells in order to support secondary cell wall formation
      Title: Disruption of the Sugar Transporters AtSWEET11 and AtSWEET12 Affects Vascular Development and Freezing Tolerance in Arabidopsis.
    4. SWEET11, 12, and 15 exhibit specific spatiotemporal expression patterns in developing seeds.
      Title: A cascade of sequentially expressed sucrose transporters in the seed coat and endosperm provides nutrition for the Arabidopsis embryo.
    5. identified subfamily of SWEET sucrose efflux transporters; AtSWEET11 and 12 localize to plasma membrane of phloem; mutant plants carrying insertions in AtSWEET11 and 12 are defective in phloem loading evealing a 2 step mechanism of SWEET-mediated export
      Title: Sucrose efflux mediated by SWEET proteins as a key step for phloem transport.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_122271.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sucrose transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sugar transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in embryo development ending in seed dormancy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein homooligomerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in seed maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sucrose transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sucrose transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    bidirectional sugar transporter SWEET12-like protein
    NP_197755.1
    • homolog of Medicago truncatula MTN3 (MTN3); INVOLVED IN: biological_process unknown; LOCATED IN: endomembrane system, integral to membrane, membrane; EXPRESSED IN: 19 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: MtN3/saliva-related transmembrane protein, conserved region (InterPro:IPR018169), RAG1-activating protein 1 homologue (InterPro:IPR018179), RAG1-activating protein-1-related (InterPro:IPR004316); BEST Arabidopsis thaliana protein match is: Nodulin MtN3 family protein (TAIR:AT3G48740.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      7971647..7973995 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_122271.3 → NP_197755.1  bidirectional sugar transporter SWEET12-like protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_197755.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O82587
      UniProtKB/TrEMBL
      A0A178U8D4
      Conserved Domains (1) summary
      pfam03083
      Location:133 → 219
      MtN3_slv; Sugar efflux transporter for intercellular exchange
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O82587.1

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