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    NUDT2 nudix hydrolase homolog 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834816, updated on 18-Sep-2024

    Summary

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    Official Symbol
    NUDT2
    Official Full Name
    nudix hydrolase homolog 2
    Primary source
    TAIR:AT5G47650
    Locus tag
    AT5G47650
    See related
    Araport:AT5G47650
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA NUDIX HYDROLASE HOMOLOG 2; ATNUDT2; ATNUDX2; MNJ7.24; MNJ7_24; nudix hydrolase homolog 2
    Summary
    Encodes an ADP-ribose pyrophosphatase that confers enhanced tolerance to oxidative stress.
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    Genomic context

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    See NUDT2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    9
    Sequence:
    Chromosome: 5; NC_003076.8 (19310192..19312747, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene mitochondrial acyl carrier protein 3 Neighboring gene Pollen Ole e 1 allergen and extensin family protein Neighboring gene ncRNA Neighboring gene nuclear factor Y, subunit B2 Neighboring gene Homeodomain-like superfamily protein Neighboring gene nuclear factor Y, subunit B6 Neighboring gene tRNA (guanine(9)-N1)-methyltransferase-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Overexpression of an ADP-ribose pyrophosphatase, AtNUDX2, confers enhanced tolerance to oxidative stress in Arabidopsis plants. Ogawa T, et al. Plant J, 2009 Jan. PMID 18798872
    2. Comprehensive analysis of cytosolic Nudix hydrolases in Arabidopsis thaliana. Ogawa T, et al. J Biol Chem, 2005 Jul 1. PMID 15878881
    3. A mesoscale abscisic acid hormone interactome reveals a dynamic signaling landscape in Arabidopsis. Lumba S, et al. Dev Cell, 2014 May 12. PMID 24823379
    4. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001344736.1
    NM_001344737.1
    NM_001344738.1
    NM_001344739.1
    NM_124139.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ADP-ribose diphosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables NAD binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables NAD+ diphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADH pyrophosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nudix hydrolase homolog 2
    NP_568687.1
    • nudix hydrolase homolog 2 (NUDT2); FUNCTIONS IN: hydrolase activity, ADP-ribose diphosphatase activity, NAD or NADH binding; INVOLVED IN: response to oxidative stress; LOCATED IN: cytosol; EXPRESSED IN: 17 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: NUDIX hydrolase domain-like (InterPro:IPR015797), Nudix hydrolase 6-like (InterPro:IPR003293), NUDIX hydrolase domain (InterPro:IPR000086); BEST Arabidopsis thaliana protein match is: nudix hydrolase homolog 10 (TAIR:AT4G25434.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      19310192..19312747 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_124139.4 → NP_568687.1  nudix hydrolase homolog 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568687.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94B74, Q9FGJ2
      UniProtKB/TrEMBL
      A0A7G2FKW1
      Conserved Domains (1) summary
      cd04670
      Location:111 → 242
      Nudix_Hydrolase_12; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...

    2. NM_001344737.1 → NP_001331652.1  nudix hydrolase homolog 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94B74, Q9FGJ2
      UniProtKB/TrEMBL
      A0A7G2FKW1

    3. NM_001344736.1 → NP_001331651.1  nudix hydrolase homolog 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BEH7, A0A5S9YBZ9

    4. NM_001344738.1 → NP_001331649.1  nudix hydrolase homolog 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BEL5, A0A5S9YBZ9

    5. NM_001344739.1 → NP_001331650.1  nudix hydrolase homolog 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94B74, Q9FGJ2
      UniProtKB/TrEMBL
      A0A7G2FKW1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q94B74.1

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