SNX2a sorting nexin 2A [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: SNX2a
Official Full Name: sorting nexin 2A
Primary source: TAIR:AT5G58440
Locus tag: AT5G58440
See related: Araport:AT5G58440
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: MQJ2.4; MQJ2_4; sorting nexin 2A
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Genomic context

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See SNX2a in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 5

Sequence:: Chromosome: 5; NC_003076.8 (23623794..23626957, complement)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A combination of immunoelectron and fluorescence microscopy show that sorting nexin 2a (SNX2a)localize to the trans-Golgi network (TGN), which is considered to represent the early endosome of plants.
Title: Retromer recycles vacuolar sorting receptors from the trans-Golgi network.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_125230.6

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables phosphatidylinositol binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within developmental process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within protein maturation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within seedling development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within signal transduction	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in multivesicular body membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info
located_in plastid	HDA more info	PubMed
part_of retromer complex	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: sorting nexin 2A

NP_200652.2

sorting nexin 2A (SNX2a); FUNCTIONS IN: phosphoinositide binding; INVOLVED IN: signal transduction, intracellular signaling pathway; LOCATED IN: cellular_component unknown; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Vps5 C-terminal (InterPro:IPR015404), Phox-like (InterPro:IPR001683); BEST Arabidopsis thaliana protein match is: sorting nexin 2B (TAIR:AT5G07120.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

23623794..23626957 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_125230.6 → NP_200652.2 sorting nexin 2A [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_200652.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8L5Z7, Q9FGH8

UniProtKB/TrEMBL

A0A178UPE2, A0A5S9YFP2

Conserved Domains (2) summary

cd06865
Location:154 → 274

PX_SNX_like; The phosphoinositide binding Phox Homology domain of SNX-like proteins

cd07596
Location:348 → 576

BAR_SNX; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexins