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    Pla2g5 phospholipase A2, group V [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29354, updated on 4-Jan-2025

    Summary

    Official Symbol
    Pla2g5provided by RGD
    Official Full Name
    phospholipase A2, group Vprovided by RGD
    Primary source
    RGD:62051
    See related
    EnsemblRapid:ENSRNOG00000016838 AllianceGenome:RGD:62051
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    PLA2-10
    Summary
    Enables calcium-dependent phospholipase A2 activity and heparin binding activity. Involved in several processes, including arachidonate secretion; leukotriene biosynthetic process; and platelet activating factor biosynthetic process. Located in perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in familial benign fleck retina. Orthologous to human PLA2G5 (phospholipase A2 group V). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Heart (RPKM 104.3), Thymus (RPKM 11.1) and 1 other tissue See more
    Orthologs
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    Genomic context

    See Pla2g5 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (156324628..156393065, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (151041339..151109433, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (157247601..157268968, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene phospholipase A2, group IIF Neighboring gene phospholipase A2, group IID Neighboring gene phospholipase A2 group IIA Neighboring gene phospholipase A2, group IIE Neighboring gene OTU deubiquitinase 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Pathways from PubChem

    General gene information

    Clone Names

    • MGC93513

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding  
    enables calcium ion binding  
    enables calcium-dependent phospholipase A2 activity  
    enables calcium-dependent phospholipase A2 activity PubMed 
    enables calcium-independent phospholipase A2 activity  
    enables calcium-independent phospholipase A2 activity  
    enables heparin binding PubMed 
    enables phospholipase A2 activity  
    enables phospholipase A2 activity  
    enables phospholipid binding  
    enables signaling receptor binding  
    Items 1 - 25 of 45
    Process Evidence Code Pubs
    involved_in arachidonate secretion PubMed 
    involved_in arachidonate secretion  
    involved_in arachidonate secretion  
    involved_in cardiolipin acyl-chain remodeling  
    involved_in cardiolipin acyl-chain remodeling  
    involved_in cardiolipin acyl-chain remodeling  
    involved_in fatty acid metabolic process  
    involved_in leukotriene biosynthetic process PubMed 
    involved_in leukotriene biosynthetic process  
    involved_in leukotriene biosynthetic process  
    involved_in lipid catabolic process  
    acts_upstream_of_or_within low-density lipoprotein particle remodeling  
    involved_in low-density lipoprotein particle remodeling  
    involved_in low-density lipoprotein particle remodeling  
    involved_in negative regulation of T cell proliferation  
    acts_upstream_of_or_within negative regulation of inflammatory response  
    involved_in phagosome-lysosome fusion  
    involved_in phagosome-lysosome fusion  
    involved_in phosphatidylcholine catabolic process  
    involved_in phosphatidylcholine catabolic process  
    involved_in phosphatidylcholine catabolic process  
    involved_in phosphatidylcholine metabolic process  
    involved_in phosphatidylglycerol metabolic process  
    involved_in phospholipid metabolic process  
    involved_in phospholipid metabolic process  
    involved_in platelet activating factor biosynthetic process PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade  
    involved_in positive regulation of ERK1 and ERK2 cascade  
    involved_in positive regulation of antifungal innate immune response  
    involved_in positive regulation of antifungal innate immune response  
    involved_in positive regulation of immune complex clearance by monocytes and macrophages  
    involved_in positive regulation of immune complex clearance by monocytes and macrophages  
    involved_in positive regulation of immune complex clearance by monocytes and macrophages  
    involved_in positive regulation of macrophage derived foam cell differentiation  
    involved_in positive regulation of macrophage derived foam cell differentiation  
    involved_in positive regulation of opsonization  
    involved_in positive regulation of opsonization  
    involved_in positive regulation of phagocytosis  
    involved_in positive regulation of phagocytosis  
    involved_in positive regulation of phagosome maturation  
    involved_in positive regulation of phagosome maturation  
    involved_in positive regulation of phospholipase activity  
    acts_upstream_of_or_within regulation of macrophage activation  
    involved_in response to cAMP PubMed 
    involved_in response to cytokine PubMed 
    Items 1 - 25 of 45
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    located_in cell surface  
    located_in early phagosome  
    located_in early phagosome  
    located_in extracellular region  
    located_in perinuclear region of cytoplasm PubMed 
    located_in phagolysosome  
    located_in phagolysosome  
    located_in plasma membrane  
    located_in recycling endosome  

    General protein information

    Preferred Names
    phospholipase A2 group V
    Names
    calcium-dependent phospholipase A2
    group V phospholipase A2
    phosphatidylcholine 2-acylhydrolase 5
    phospholipase A2, group 5
    NP_058870.1
    XP_006239201.1
    XP_008762432.1
    XP_063143324.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429594.1NP_001416523.1  phospholipase A2 group V precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      P51433, Q6DQ96
      UniProtKB/TrEMBL
      A0A8I6A5J8, A6ITI7
    2. NM_001429595.1NP_001416524.1  phospholipase A2 group V precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      P51433, Q6DQ96
      UniProtKB/TrEMBL
      A0A8I6A5J8, A6ITI7
    3. NM_001429596.1NP_001416525.1  phospholipase A2 group V precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      P51433, Q6DQ96
      UniProtKB/TrEMBL
      A0A8I6A5J8, A6ITI7
    4. NM_001429597.1NP_001416526.1  phospholipase A2 group V precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      P51433, Q6DQ96
      UniProtKB/TrEMBL
      A0A8I6A5J8, A6ITI7
    5. NM_017174.3NP_058870.1  phospholipase A2 group V precursor

      See identical proteins and their annotated locations for NP_058870.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      P51433, Q6DQ96
      UniProtKB/TrEMBL
      A0A8I6A5J8, A6ITI7
      Related
      ENSRNOP00000107135.1, ENSRNOT00000125347.1
      Conserved Domains (1) summary
      smart00085
      Location:22137
      PA2c; Phospholipase A2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      156324628..156393065 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287254.1XP_063143324.1  phospholipase A2 group V isoform X1

      UniProtKB/Swiss-Prot
      P51433, Q6DQ96
      UniProtKB/TrEMBL
      A0A8I6A5J8, A6ITI7
    2. XM_006239139.5XP_006239201.1  phospholipase A2 group V isoform X1

      Conserved Domains (1) summary
      smart00085
      Location:22137
      PA2c; Phospholipase A2
    3. XM_008764210.4XP_008762432.1  phospholipase A2 group V isoform X1

      Conserved Domains (1) summary
      smart00085
      Location:22137
      PA2c; Phospholipase A2
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