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    Mitochondrial substrate carrier family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 832096, updated on 18-Sep-2024

    Summary

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    Official Full Name
    Mitochondrial substrate carrier family protein
    Primary source
    TAIR:AT5G19760
    Locus tag
    AT5G19760
    See related
    Araport:AT5G19760
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    T29J13.180; T29J13_180
    Summary
    Encodes a novel mitochondrial carrier capable of transporting both dicarboxylates (such as malate, oxaloacetate, oxoglutarate, and maleate) and tricarboxylates (such as citrate, isocitrate, cis-aconitate, and trans-aconitate).
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    Genomic context

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    Location:
    chromosome: 5
    Exon count:
    6
    Sequence:
    Chromosome: 5; NC_003076.8 (6679306..6682054, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Pectin lyase-like superfamily protein Neighboring gene Peptidase M28 family protein Neighboring gene Peroxisomal membrane 22 kDa (Mpv17/PMP22) family protein Neighboring gene tubulin alpha-3 Neighboring gene tubulin alpha-5 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of a novel transporter for dicarboxylates and tricarboxylates in plant mitochondria. Bacterial expression, reconstitution, functional characterization, and tissue distribution. Picault N, et al. J Biol Chem, 2002 Jul 5. PMID 11978797
    2. The Arabidopsis class II sirtuin is a lysine deacetylase and interacts with mitochondrial energy metabolism. König AC, et al. Plant Physiol, 2014 Mar. PMID 24424322, Free PMC Article
    3. The hydrophobic proteome of mitochondrial membranes from Arabidopsis cell suspensions. Brugière S, et al. Phytochemistry, 2004 Jun. PMID 15276431
    4. The Arabidopsis Proteins AtNHR2A and AtNHR2B Are Multi-Functional Proteins Integrating Plant Immunity With Other Biological Processes. Singh R, et al. Front Plant Sci, 2020. PMID 32194606, Free PMC Article
    5. Arabidopsis cell wall proteome defined using multidimensional protein identification technology. Bayer EM, et al. Proteomics, 2006 Jan. PMID 16287169

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_121981.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables dicarboxylic acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidative phosphorylation uncoupler activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables tricarboxylic acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within dicarboxylic acid transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within tricarboxylic acid transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    NOT located_in Golgi apparatus RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in chloroplast envelope HDA PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plant-type cell wall HDA PubMed 
    located_in plant-type vacuole HDA PubMed 
    located_in plasmodesma HDA PubMed 
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    Mitochondrial substrate carrier family protein
    NP_197477.1
    • Mitochondrial substrate carrier family protein; FUNCTIONS IN: oxidative phosphorylation uncoupler activity, binding; INVOLVED IN: transport, mitochondrial transport, transmembrane transport; LOCATED IN: in 6 components; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: Mitochondrial carrier protein (InterPro:IPR002067), Mitochondrial substrate carrier (InterPro:IPR001993), Mitochondrial substrate/solute carrier (InterPro:IPR018108); BEST Arabidopsis thaliana protein match is: dicarboxylate carrier 2 (TAIR:AT4G24570.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      6679306..6682054 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_121981.5 → NP_197477.1  Mitochondrial substrate carrier family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_197477.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8SFL2, Q9C5M0
      UniProtKB/TrEMBL
      A0A178UIU8, A0A5S9Y5N3, A0A7G2F9X4
      Conserved Domains (1) summary
      pfam00153
      Location:101 → 199
      Mito_carr; Mitochondrial carrier protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C5M0.1

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