Slc16a8 solute carrier family 16 (monocarboxylic acid transporters), member 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc16a8provided by MGI
Official Full Name: solute carrier family 16 (monocarboxylic acid transporters), member 8provided by MGI
Primary source: MGI:MGI:1929519
See related: Ensembl:ENSMUSG00000032988 AllianceGenome:MGI:1929519
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mct3
Summary: Predicted to enable monocarboxylic acid transmembrane transporter activity. Predicted to be involved in lactate transmembrane transport. Located in basolateral plasma membrane. Orthologous to human SLC16A8 (solute carrier family 16 member 8). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in colon adult (RPKM 1.5), ovary adult (RPKM 1.4) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 E1; 15 37.7 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (79135216..79139619, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (79251016..79255562, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Disruption of Mct3 leads to a potentially reversible decrease in subretinal space pH, thereby reducing the magnitude of the light suppressible photoreceptor current.
Title: Altered visual function in monocarboxylate transporter 3 (Slc16a8) knockout mice.
MCT8-null mice developed without overt deficits but also exhibited distorted 3,5,3'-triiodothyronine (T3) and thyroxine (T4) serum levels, resulting in increased hepatic activity of type 1 deiodinase (D1).
Title: Abnormal thyroid hormone metabolism in mice lacking the monocarboxylate transporter 8.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

General gene information

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Markers

Slc16a8 (e-PCR), detects polymorphism
- UniSTS:461935

Slc16a8 (e-PCR), detects polymorphism
- UniSTS:461936

Slc16a8 (e-PCR), detects polymorphism
- UniSTS:547003

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables monocarboxylic acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables monocarboxylic acid transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables symporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in lactate transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basal plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: monocarboxylate transporter 3

Names: MCT 3; preferentially expressed in RPE cells and choroid plexus epithelium; proton-coupled monocarboxylate transporter 3; solute carrier family 16 member 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_020516.2 → NP_065262.1 monocarboxylate transporter 3

See identical proteins and their annotated locations for NP_065262.1

Status: PROVISIONAL

Source sequence(s)

BC018216

Consensus CDS

CCDS27636.1

UniProtKB/Swiss-Prot

O35308

UniProtKB/TrEMBL

Q5UB50

Related

ENSMUSP00000040522.4, ENSMUST00000039752.4

Conserved Domains (1) summary

TIGR00892
Location:14 → 440

2A0113; monocarboxylate transporter 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

79135216..79139619 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017316713.3 → XP_017172202.1 monocarboxylate transporter 3 isoform X1

UniProtKB/Swiss-Prot

O35308

UniProtKB/TrEMBL

Q5UB50

Conserved Domains (1) summary

TIGR00892
Location:14 → 440

2A0113; monocarboxylate transporter 1