Faap100 Fanconi anemia core complex associated protein 100 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Faap100provided by MGI
Official Full Name: Fanconi anemia core complex associated protein 100provided by MGI
Primary source: MGI:MGI:1919135
See related: Ensembl:ENSMUSG00000025384 AllianceGenome:MGI:1919135
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2310003H01Rik
Summary: Predicted to enable DNA binding activity. Predicted to be involved in interstrand cross-link repair. Predicted to be located in chromatin and cytosol. Predicted to be part of Fanconi anaemia nuclear complex. Predicted to be active in nucleoplasm. Is expressed in bladder; bone; nervous system; rib; and tail paraxial mesenchyme. Orthologous to human FAAP100 (FA core complex associated protein 100). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 55.4), ovary adult (RPKM 37.1) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E2; 11 84.08 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (120260388..120269572, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (120369562..120378746, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FAAP100 is required for the resolution of transcription-replication conflicts in primordial germ cells.
Title: FAAP100 is required for the resolution of transcription-replication conflicts in primordial germ cells.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in interstrand cross-link repair	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of Fanconi anaemia nuclear complex	IEA Inferred from Electronic Annotation more info
located_in chromatin	IEA Inferred from Electronic Annotation more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: Fanconi anemia core complex-associated protein 100

Names: fanconi anemia-associated protein of 100 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027980.2 → NP_082256.2 Fanconi anemia core complex-associated protein 100

Status: VALIDATED

Source sequence(s)

AL669855

Consensus CDS

CCDS49004.1

UniProtKB/Swiss-Prot

A2ACJ2, Q0P653, Q810W2

Related

ENSMUSP00000026448.10, ENSMUST00000026448.10

Conserved Domains (1) summary

pfam15146
Location:447 → 879

FANCAA; Fanconi anemia-associated