Psmd4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Psmd4provided by MGI
Official Full Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 4provided by MGI
Primary source: MGI:MGI:1201670
See related: Ensembl:ENSMUSG00000005625 AllianceGenome:MGI:1201670
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Af1; Mcb1; angiocidin
Summary: Predicted to enable identical protein binding activity; molecular adaptor activity; and polyubiquitin modification-dependent protein binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Part of proteasome accessory complex. Is expressed in brain; liver; and surface ectoderm. Orthologous to human PSMD4 (proteasome 26S subunit ubiquitin receptor, non-ATPase 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 83.0), placenta adult (RPKM 82.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F2.1; 3 40.74 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (94939999..94949880, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (95032688..95042614, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the neuroprotective dose of isatin used in this study can result in brain isatin concentrations that are proapoptotic for cells in vitro, the altered repertoire of mitochondrial Rpn10-binding proteins may thus represent a part of a switch mechanism from targeted elimination of individual (damaged) proteins to more efficient ("global") elimination of damaged organelles and whole damaged cells.
Title: Brain Mitochondrial Subproteome of Rpn10-Binding Proteins and Its Changes Induced by the Neurotoxin MPTP and the Neuroprotector Isatin.
this study showed that Rpn13 plays a redundant role with Rpn10 in recognition and degradation of ubiquitinated proteins in mouse livers.
Title: Redundant Roles of Rpn10 and Rpn13 in Recognition of Ubiquitinated Proteins and Cellular Homeostasis.
Results demonstrate that Rpn10-mediated degradation of ubiquitinated proteins, catalyzed by ubiquitin-interacting motifs, is indispensable for mammalian life.
Title: Rpn10-mediated degradation of ubiquitinated proteins is essential for mouse development.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Psmd4 (e-PCR), detects polymorphism
- UniSTS:259650

RH125088 (e-PCR)
- UniSTS:161910

Af1 (e-PCR), detects polymorphism
- UniSTS:141045

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables polyubiquitin modification-dependent protein binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome accessory complex	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome complex	ISO Inferred from Sequence Orthology more info
part_of proteasome regulatory particle, base subcomplex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: 26S proteasome non-ATPase regulatory subunit 4

Names: 26S proteasome regulatory subunit RPN10; 26S proteasome regulatory subunit S5A; RPN10 homolog; anti secretory factor 1; multiubiquitin chain-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001282017.2 → NP_001268946.1 26S proteasome non-ATPase regulatory subunit 4 isoform 1

See identical proteins and their annotated locations for NP_001268946.1

Status: VALIDATED

Source sequence(s)

AC087062

Consensus CDS

CCDS71287.1

UniProtKB/TrEMBL

Q3ULG4, Q9CY29

Related

ENSMUSP00000071589.6, ENSMUST00000071664.12

Conserved Domains (1) summary

cd01452
Location:1 → 187

VWA_26S_proteasome_subunit; 26S proteasome plays a major role in eukaryotic protein breakdown, especially for ubiquitin-tagged proteins. It is an ATP-dependent protease responsible for the bulk of non-lysosomal proteolysis in eukaryotes, often using covalent modification of ...
NM_001410538.1 → NP_001397467.1 26S proteasome non-ATPase regulatory subunit 4 isoform 3

Status: VALIDATED

Source sequence(s)

AC087062

UniProtKB/TrEMBL

Q9CY29
NM_001410539.1 → NP_001397468.1 26S proteasome non-ATPase regulatory subunit 4 isoform 4

Status: VALIDATED

Source sequence(s)

AC087062

UniProtKB/TrEMBL

Q9CY29
NM_001410540.1 → NP_001397469.1 26S proteasome non-ATPase regulatory subunit 4 isoform 5

Status: VALIDATED

Source sequence(s)

AC087062

UniProtKB/TrEMBL

Q9CY29
NM_001410541.1 → NP_001397470.1 26S proteasome non-ATPase regulatory subunit 4 isoform 6

Status: VALIDATED

Source sequence(s)

AC087062

UniProtKB/TrEMBL

Q9CY29
NM_001410542.1 → NP_001397471.1 26S proteasome non-ATPase regulatory subunit 4 isoform 7

Status: VALIDATED

Source sequence(s)

AC087062

UniProtKB/TrEMBL

Q9CY29
NM_001410543.1 → NP_001397472.1 26S proteasome non-ATPase regulatory subunit 4 isoform 8

Status: VALIDATED

Source sequence(s)

AC087062
NM_008951.3 → NP_032977.1 26S proteasome non-ATPase regulatory subunit 4 isoform 2

See identical proteins and their annotated locations for NP_032977.1

Status: VALIDATED

Source sequence(s)

AC087062

Consensus CDS

CCDS38541.1

UniProtKB/Swiss-Prot

O35226, Q91V59, Q9JJM0, Q9JJM1, Q9JJM2, Q9JJM3

UniProtKB/TrEMBL

Q9CY29

Related

ENSMUSP00000102857.2, ENSMUST00000107237.8

Conserved Domains (1) summary

cd01452
Location:1 → 187

VWA_26S_proteasome_subunit; 26S proteasome plays a major role in eukaryotic protein breakdown, especially for ubiquitin-tagged proteins. It is an ATP-dependent protease responsible for the bulk of non-lysosomal proteolysis in eukaryotes, often using covalent modification of ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

94939999..94949880 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030252465.1 → XP_030108325.1 26S proteasome non-ATPase regulatory subunit 4 isoform X2

Conserved Domains (2) summary

NF033415
Location:202 → 257

thiovirid_RiPP; thioviridamide family RiPP peptide

cl00057
Location:1 → 81

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
XM_006501137.3 → XP_006501200.1 26S proteasome non-ATPase regulatory subunit 4 isoform X1

Conserved Domains (2) summary

NF033415
Location:205 → 260

thiovirid_RiPP; thioviridamide family RiPP peptide

cl00057
Location:1 → 81

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...