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    Tanc2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 77097, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tanc2provided by MGI
    Official Full Name
    tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2provided by MGI
    Primary source
    MGI:MGI:2444121
    See related
    Ensembl:ENSMUSG00000053580 AllianceGenome:MGI:2444121
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    3526402J09Rik; 5730590C14Rik
    Summary
    Acts upstream of or within in utero embryonic development. Predicted to be located in axon. Predicted to be active in dendritic spine; glutamatergic synapse; and postsynaptic density, intracellular component. Is expressed in cerebral cortex ventricular layer; cortical plate; and neocortex. Human ortholog(s) of this gene implicated in intellectual developmental disorder with autistic features and language delay, with or without seizures. Orthologous to human TANC2 (tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in frontal lobe adult (RPKM 11.5), CNS E18 (RPKM 11.4) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tanc2 in Genome Data Viewer
    Location:
    11 E1; 11 68.73 cM
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (105480458..105820130)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (105589460..105929304)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_30908 Neighboring gene predicted gene, 35828 Neighboring gene predicted gene, 39422 Neighboring gene STARR-positive B cell enhancer mm9_chr11:105453342-105453643 Neighboring gene basic leucine zipper and W2 domains 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_30909 Neighboring gene STARR-seq mESC enhancer starr_30910 Neighboring gene snurportin 1 pseudogene Neighboring gene predicted gene, 53650 Neighboring gene STARR-seq mESC enhancer starr_30912 Neighboring gene cytochrome b-561 Neighboring gene predicted gene 9910 Neighboring gene predicted gene 11651 Neighboring gene angiotensin I converting enzyme

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Post-synaptic scaffold protein TANC2 in psychiatric and somatic disease risk. Garrett L, et al. Dis Model Mech, 2022 Mar 1. PMID 34964047, Free PMC Article
    2. Tanc2-mediated mTOR inhibition balances mTORC1/2 signaling in the developing mouse brain and human neurons. Kim SG, et al. Nat Commun, 2021 May 11. PMID 33976205, Free PMC Article
    3. Tanc1/2 TPR domain interacts with Myo18a C-terminus and undergoes liquid-liquid phase separation. Yang Q, et al. Biochim Biophys Acta Mol Cell Res, 2024 Feb. PMID 38092135
    4. Regulation of dendritic spines, spatial memory, and embryonic development by the TANC family of PSD-95-interacting proteins. Han S, et al. J Neurosci, 2010 Nov 10. PMID 21068316, Free PMC Article
    5. Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST. Nakano Y, et al. Cell Rep, 2019 Apr 16. PMID 30995482, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tanc1/2 TPR domain interacts with Myo18a C-terminus and undergoes liquid-liquid phase separation.
      Title: Tanc1/2 TPR domain interacts with Myo18a C-terminus and undergoes liquid-liquid phase separation.
    2. Post-synaptic scaffold protein TANC2 in psychiatric and somatic disease risk.
      Title: Post-synaptic scaffold protein TANC2 in psychiatric and somatic disease risk.
    3. Tanc2-mediated mTOR inhibition balances mTORC1/2 signaling in the developing mouse brain and human neurons.
      Title: Tanc2-mediated mTOR inhibition balances mTORC1/2 signaling in the developing mouse brain and human neurons.
    4. these results implicate TANC2 in embryonic development.
      Title: Regulation of dendritic spines, spatial memory, and embryonic development by the TANC family of PSD-95-interacting proteins.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in dense core granule cytoskeletal transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dense core granule cytoskeletal transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of dendritic spine development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of dendritic spine development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of dendritic spine morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of dendritic spine morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of dendritic spine morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in dendritic spine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendritic spine ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic density, intracellular component ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein TANC2
    Names
    tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_181071.3 → NP_851416.2  protein TANC2

      See identical proteins and their annotated locations for NP_851416.2

      Status: VALIDATED

      Source sequence(s)
      AI413677, AK051973, AK173111, AL596246, BP766228
      Consensus CDS
      CCDS36357.1
      UniProtKB/Swiss-Prot
      A2A683, A2A690, Q3TRZ3, Q5EBP6, Q69ZQ7
      Related
      ENSMUSP00000097904.4, ENSMUST00000100330.10
      Conserved Domains (10) summary
      cd00204
      Location:1094 → 1219
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00006
      Location:1247 → 1272
      TPR; TPR repeat [structural motif]
      pfam03153
      Location:1408 → 1633
      TFIIA; Transcription factor IIA, alpha/beta subunit
      pfam12796
      Location:1104 → 1196
      Ank_2; Ankyrin repeats (3 copies)
      pfam13191
      Location:341 → 383
      AAA_16; AAA ATPase domain
      pfam13414
      Location:1293 → 1356
      TPR_11; TPR repeat
      pfam13428
      Location:1326 → 1368
      TPR_14; Tetratricopeptide repeat
      pfam13637
      Location:888 → 937
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:1100 → 1130
      ANK; ANK repeat [structural motif]
      cl14876
      Location:395 → 539
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      105480458..105820130
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534472.4 → XP_006534535.1  protein TANC2 isoform X1

      Conserved Domains (7) summary
      PHA03095
      Location:930 → 1224
      PHA03095; ankyrin-like protein; Provisional
      PHA03247
      Location:1515 → 1745
      PHA03247; large tegument protein UL36; Provisional
      COG0457
      Location:1324 → 1442
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      COG0666
      Location:1170 → 1296
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00006
      Location:1331 → 1356
      TPR; TPR repeat [structural motif]
      sd00045
      Location:1174 → 1204
      ANK; ANK repeat [structural motif]
      pfam13191
      Location:415 → 500
      AAA_16; AAA ATPase domain

    2. XM_006534473.4 → XP_006534536.1  protein TANC2 isoform X2

      Conserved Domains (7) summary
      PHA03095
      Location:930 → 1224
      PHA03095; ankyrin-like protein; Provisional
      PHA03247
      Location:1514 → 1744
      PHA03247; large tegument protein UL36; Provisional
      COG0457
      Location:1324 → 1441
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      COG0666
      Location:1170 → 1296
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00006
      Location:1331 → 1356
      TPR; TPR repeat [structural motif]
      sd00045
      Location:1174 → 1204
      ANK; ANK repeat [structural motif]
      pfam13191
      Location:415 → 500
      AAA_16; AAA ATPase domain

    3. XM_006534482.5 → XP_006534545.1  protein TANC2 isoform X9

      Conserved Domains (4) summary
      PHA03095
      Location:930 → 1224
      PHA03095; ankyrin-like protein; Provisional
      COG0666
      Location:1170 → 1296
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:1174 → 1204
      ANK; ANK repeat [structural motif]
      pfam13191
      Location:415 → 500
      AAA_16; AAA ATPase domain

    4. XM_006534474.4 → XP_006534537.1  protein TANC2 isoform X3

      Conserved Domains (7) summary
      PHA03095
      Location:930 → 1224
      PHA03095; ankyrin-like protein; Provisional
      PHA03247
      Location:1505 → 1735
      PHA03247; large tegument protein UL36; Provisional
      COG0457
      Location:1314 → 1432
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      COG0666
      Location:1170 → 1296
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00006
      Location:1321 → 1346
      TPR; TPR repeat [structural motif]
      sd00045
      Location:1174 → 1204
      ANK; ANK repeat [structural motif]
      pfam13191
      Location:415 → 500
      AAA_16; AAA ATPase domain

    5. XM_006534475.4 → XP_006534538.1  protein TANC2 isoform X4

      Conserved Domains (7) summary
      PHA03095
      Location:930 → 1224
      PHA03095; ankyrin-like protein; Provisional
      PHA03247
      Location:1504 → 1734
      PHA03247; large tegument protein UL36; Provisional
      COG0457
      Location:1314 → 1431
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      COG0666
      Location:1170 → 1296
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00006
      Location:1321 → 1346
      TPR; TPR repeat [structural motif]
      sd00045
      Location:1174 → 1204
      ANK; ANK repeat [structural motif]
      pfam13191
      Location:415 → 500
      AAA_16; AAA ATPase domain

    6. XM_006534483.5 → XP_006534546.1  protein TANC2 isoform X10

      Conserved Domains (5) summary
      PHA03095
      Location:1083 → 1303
      PHA03095; ankyrin-like protein; Provisional
      COG0666
      Location:878 → 1046
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:1174 → 1204
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:1178 → 1270
      Ank_2; Ankyrin repeats (3 copies)
      pfam13191
      Location:415 → 500
      AAA_16; AAA ATPase domain

    7. XM_006534476.4 → XP_006534539.1  protein TANC2 isoform X5

      Conserved Domains (7) summary
      PHA03095
      Location:893 → 1187
      PHA03095; ankyrin-like protein; Provisional
      PHA03247
      Location:1478 → 1708
      PHA03247; large tegument protein UL36; Provisional
      COG0457
      Location:1287 → 1405
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      COG0666
      Location:1133 → 1259
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00006
      Location:1294 → 1319
      TPR; TPR repeat [structural motif]
      sd00045
      Location:1137 → 1167
      ANK; ANK repeat [structural motif]
      pfam13191
      Location:378 → 463
      AAA_16; AAA ATPase domain

    8. XM_006534477.4 → XP_006534540.1  protein TANC2 isoform X6

      Conserved Domains (7) summary
      PHA03095
      Location:893 → 1187
      PHA03095; ankyrin-like protein; Provisional
      COG0457
      Location:1287 → 1405
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      COG0666
      Location:1133 → 1259
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00006
      Location:1294 → 1319
      TPR; TPR repeat [structural motif]
      sd00045
      Location:1137 → 1167
      ANK; ANK repeat [structural motif]
      pfam15240
      Location:1493 → 1645
      Pro-rich; Proline-rich
      pfam13191
      Location:378 → 463
      AAA_16; AAA ATPase domain

    9. XM_006534478.3 → XP_006534541.1  protein TANC2 isoform X7

      Conserved Domains (7) summary
      PHA03095
      Location:856 → 1150
      PHA03095; ankyrin-like protein; Provisional
      COG0457
      Location:1250 → 1368
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      COG0666
      Location:1096 → 1222
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00006
      Location:1257 → 1282
      TPR; TPR repeat [structural motif]
      sd00045
      Location:1100 → 1130
      ANK; ANK repeat [structural motif]
      pfam15240
      Location:1456 → 1608
      Pro-rich; Proline-rich
      pfam13191
      Location:341 → 426
      AAA_16; AAA ATPase domain

    10. XM_006534480.5 → XP_006534543.1  protein TANC2 isoform X8

      See identical proteins and their annotated locations for XP_006534543.1

      Conserved Domains (7) summary
      PHA03095
      Location:766 → 1060
      PHA03095; ankyrin-like protein; Provisional
      COG0457
      Location:1160 → 1278
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      COG0666
      Location:1006 → 1132
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00006
      Location:1167 → 1192
      TPR; TPR repeat [structural motif]
      sd00045
      Location:1010 → 1040
      ANK; ANK repeat [structural motif]
      pfam15240
      Location:1366 → 1518
      Pro-rich; Proline-rich
      pfam13191
      Location:251 → 336
      AAA_16; AAA ATPase domain

    11. XM_006534481.5 → XP_006534544.1  protein TANC2 isoform X8

      See identical proteins and their annotated locations for XP_006534544.1

      Conserved Domains (7) summary
      PHA03095
      Location:766 → 1060
      PHA03095; ankyrin-like protein; Provisional
      COG0457
      Location:1160 → 1278
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      COG0666
      Location:1006 → 1132
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00006
      Location:1167 → 1192
      TPR; TPR repeat [structural motif]
      sd00045
      Location:1010 → 1040
      ANK; ANK repeat [structural motif]
      pfam15240
      Location:1366 → 1518
      Pro-rich; Proline-rich
      pfam13191
      Location:251 → 336
      AAA_16; AAA ATPase domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_175492.2: Suppressed sequence

      Description
      NM_175492.2: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2A690.1 GenPept UniProtKB/Swiss-Prot:A2A690

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