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    Mga MAX gene associated [ Mus musculus (house mouse) ]

    Gene ID: 29808, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mgaprovided by MGI
    Official Full Name
    MAX gene associatedprovided by MGI
    Primary source
    MGI:MGI:1352483
    See related
    Ensembl:ENSMUSG00000033943 AllianceGenome:MGI:1352483
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mad5; C130042M01Rik; D030062C11Rik
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within cellular response to leukemia inhibitory factor. Part of transcription regulator complex. Is expressed in several structures, including genitourinary system; gut; heart; nervous system; and sensory organ. Orthologous to human MGA (MAX dimerization protein MGA). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 3.0), CNS E11.5 (RPKM 2.8) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mga in Genome Data Viewer
    Location:
    2 E5; 2 59.97 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (119702974..119800610)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (119872503..119970129)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 23814 Neighboring gene TYRO3 protein tyrosine kinase 3 Neighboring gene STARR-seq mESC enhancer starr_05497 Neighboring gene STARR-seq mESC enhancer starr_05498 Neighboring gene STARR-seq mESC enhancer starr_05499 Neighboring gene fatty acid binding protein 5, epidermal pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E1252 Neighboring gene mitogen-activated protein kinase binding protein 1 Neighboring gene microRNA 7665 Neighboring gene predicted gene, 28042 Neighboring gene jumonji domain containing 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Postimplantation Mga expression and embryonic lethality of two gene-trap alleles. Burn SF, et al. Gene Expr Patterns, 2018 Jan. PMID 29066359, Free PMC Article
    2. Mga safeguards embryonic stem cells from acquiring extraembryonic endoderm fates. Qin J, et al. Sci Adv, 2021 Jan. PMID 33523934, Free PMC Article
    3. Two DNA binding domains of MGA act in combination to suppress ectopic activation of meiosis-related genes in mouse embryonic stem cells. Uranishi K, et al. Stem Cells, 2021 Nov. PMID 34224650
    4. Identification of germ cell-specific Mga variant mRNA that promotes meiosis via impediment of a non-canonical PRC1. Kitamura Y, et al. Sci Rep, 2021 May 6. PMID 33958653, Free PMC Article
    5. Functional characterization of cooperating MGA mutations in RUNX1::RUNX1T1 acute myeloid leukemia. Thomas ME 3rd, et al. Leukemia, 2024 May. PMID 38454121, Free PMC Article

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Functional characterization of cooperating MGA mutations in RUNX1::RUNX1T1 acute myeloid leukemia.
      Title: Functional characterization of cooperating MGA mutations in RUNX1::RUNX1T1 acute myeloid leukemia.
    2. SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.
      Title: SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.
    3. Two DNA binding domains of MGA act in combination to suppress ectopic activation of meiosis-related genes in mouse embryonic stem cells.
      Title: Two DNA binding domains of MGA act in combination to suppress ectopic activation of meiosis-related genes in mouse embryonic stem cells.
    4. Mga safeguards embryonic stem cells from acquiring extraembryonic endoderm fates.
      Title: Mga safeguards embryonic stem cells from acquiring extraembryonic endoderm fates.
    5. Repression of germline genes by PRC1.6 and SETDB1 in the early embryo precedes DNA methylation-mediated silencing.
      Title: Repression of germline genes by PRC1.6 and SETDB1 in the early embryo precedes DNA methylation-mediated silencing.
    6. Identification of germ cell-specific Mga variant mRNA that promotes meiosis via impediment of a non-canonical PRC1.
      Title: Identification of germ cell-specific Mga variant mRNA that promotes meiosis via impediment of a non-canonical PRC1.
    7. Loss of Mga expression in two gene-trap alleles results in embryonic lethality
      Title: Postimplantation Mga expression and embryonic lethality of two gene-trap alleles.
    8. These results suggest a mechanism whereby Mga influences pluripotent cell survival.
      Title: Mga is essential for the survival of pluripotent cells during peri-implantation development.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell fate specification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of MLL1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MLL1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of MLL1 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    MAX gene-associated protein
    Names
    MAX-interacting protein
    Max dimerization protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164274.1 → NP_001157746.1  MAX gene-associated protein isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AL954662
      Consensus CDS
      CCDS50675.1
      UniProtKB/Swiss-Prot
      A2AWL6, A2AWL7, Q3TS36, Q6A056, Q8BQX1, Q8CCL4, Q9QXJ5
      UniProtKB/TrEMBL
      H7BX50
      Related
      ENSMUSP00000078853.6, ENSMUST00000079934.12
      Conserved Domains (3) summary
      cd00182
      Location:74 → 264
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
      pfam00010
      Location:2194 → 2244
      HLH; Helix-loop-helix DNA-binding domain
      pfam16059
      Location:1038 → 1084
      DUF4801; Domain of unknown function (DUF4801)

    2. NM_013720.2 → NP_038748.2  MAX gene-associated protein isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AF205935, AK046252, AK172962, AL954662, BQ552371, CD539587, CN725372
      Consensus CDS
      CCDS38208.1
      UniProtKB/Swiss-Prot
      A2AWL6, A2AWL7, Q3TS36, Q6A056, Q8BQX1, Q8CCL4, Q9QXJ5
      UniProtKB/TrEMBL
      E9QLG3
      Related
      ENSMUSP00000106401.2, ENSMUST00000110774.8
      Conserved Domains (4) summary
      pfam05109
      Location:1447 → 1775
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cd18911
      Location:2403 → 2467
      bHLHzip_MGA; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) and similar proteins
      pfam16059
      Location:1038 → 1079
      DUF4801; Domain of unknown function (DUF4801)
      cd20195
      Location:75 → 260
      T-box_MGA-like; DNA-binding domain of MAX gene-associated protein and related T-box proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      119702974..119800610
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499691.5 → XP_006499754.1  MAX gene-associated protein isoform X1

      See identical proteins and their annotated locations for XP_006499754.1

      UniProtKB/Swiss-Prot
      A2AWL6, A2AWL7, Q3TS36, Q6A056, Q8BQX1, Q8CCL4, Q9QXJ5
      Conserved Domains (5) summary
      cd00182
      Location:74 → 264
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
      pfam03154
      Location:1729 → 2023
      Atrophin-1; Atrophin-1 family
      pfam16059
      Location:1038 → 1080
      DUF4801; Domain of unknown function (DUF4801)
      pfam17823
      Location:1510 → 1811
      DUF5585; Family of unknown function (DUF5585)
      cd18911
      Location:2452 → 2516
      bHLHzip_MGA; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) and similar proteins

    2. XM_006499689.3 → XP_006499752.1  MAX gene-associated protein isoform X1

      See identical proteins and their annotated locations for XP_006499752.1

      UniProtKB/Swiss-Prot
      A2AWL6, A2AWL7, Q3TS36, Q6A056, Q8BQX1, Q8CCL4, Q9QXJ5
      Conserved Domains (5) summary
      cd00182
      Location:74 → 264
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
      pfam03154
      Location:1729 → 2023
      Atrophin-1; Atrophin-1 family
      pfam16059
      Location:1038 → 1080
      DUF4801; Domain of unknown function (DUF4801)
      pfam17823
      Location:1510 → 1811
      DUF5585; Family of unknown function (DUF5585)
      cd18911
      Location:2452 → 2516
      bHLHzip_MGA; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) and similar proteins

    3. XM_030251727.2 → XP_030107587.1  MAX gene-associated protein isoform X7

      Conserved Domains (3) summary
      pfam05109
      Location:53 → 280
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam03154
      Location:185 → 479
      Atrophin-1; Atrophin-1 family
      cd18911
      Location:908 → 972
      bHLHzip_MGA; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) and similar proteins

    4. XM_006499687.5 → XP_006499750.1  MAX gene-associated protein isoform X1

      See identical proteins and their annotated locations for XP_006499750.1

      UniProtKB/Swiss-Prot
      A2AWL6, A2AWL7, Q3TS36, Q6A056, Q8BQX1, Q8CCL4, Q9QXJ5
      Conserved Domains (5) summary
      cd00182
      Location:74 → 264
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
      pfam03154
      Location:1729 → 2023
      Atrophin-1; Atrophin-1 family
      pfam16059
      Location:1038 → 1080
      DUF4801; Domain of unknown function (DUF4801)
      pfam17823
      Location:1510 → 1811
      DUF5585; Family of unknown function (DUF5585)
      cd18911
      Location:2452 → 2516
      bHLHzip_MGA; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) and similar proteins

    5. XM_006499690.5 → XP_006499753.1  MAX gene-associated protein isoform X1

      See identical proteins and their annotated locations for XP_006499753.1

      UniProtKB/Swiss-Prot
      A2AWL6, A2AWL7, Q3TS36, Q6A056, Q8BQX1, Q8CCL4, Q9QXJ5
      Conserved Domains (5) summary
      cd00182
      Location:74 → 264
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
      pfam03154
      Location:1729 → 2023
      Atrophin-1; Atrophin-1 family
      pfam16059
      Location:1038 → 1080
      DUF4801; Domain of unknown function (DUF4801)
      pfam17823
      Location:1510 → 1811
      DUF5585; Family of unknown function (DUF5585)
      cd18911
      Location:2452 → 2516
      bHLHzip_MGA; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) and similar proteins

    6. XM_006499688.5 → XP_006499751.1  MAX gene-associated protein isoform X1

      See identical proteins and their annotated locations for XP_006499751.1

      UniProtKB/Swiss-Prot
      A2AWL6, A2AWL7, Q3TS36, Q6A056, Q8BQX1, Q8CCL4, Q9QXJ5
      Conserved Domains (5) summary
      cd00182
      Location:74 → 264
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
      pfam03154
      Location:1729 → 2023
      Atrophin-1; Atrophin-1 family
      pfam16059
      Location:1038 → 1080
      DUF4801; Domain of unknown function (DUF4801)
      pfam17823
      Location:1510 → 1811
      DUF5585; Family of unknown function (DUF5585)
      cd18911
      Location:2452 → 2516
      bHLHzip_MGA; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) and similar proteins

    7. XM_011239591.3 → XP_011237893.1  MAX gene-associated protein isoform X5

      UniProtKB/Swiss-Prot
      A2AWL6, A2AWL7, Q3TS36, Q6A056, Q8BQX1, Q8CCL4, Q9QXJ5
      Conserved Domains (3) summary
      cd00182
      Location:74 → 264
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
      pfam16059
      Location:1038 → 1080
      DUF4801; Domain of unknown function (DUF4801)
      cd18911
      Location:2244 → 2308
      bHLHzip_MGA; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) and similar proteins

    8. XM_011239592.3 → XP_011237894.1  MAX gene-associated protein isoform X6

      UniProtKB/Swiss-Prot
      A2AWL6, A2AWL7, Q3TS36, Q6A056, Q8BQX1, Q8CCL4, Q9QXJ5
      Conserved Domains (4) summary
      cd00182
      Location:74 → 264
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
      pfam03154
      Location:1395 → 1766
      Atrophin-1; Atrophin-1 family
      pfam16059
      Location:1038 → 1080
      DUF4801; Domain of unknown function (DUF4801)
      cd18911
      Location:2195 → 2259
      bHLHzip_MGA; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) and similar proteins

    9. XM_011239589.4 → XP_011237891.1  MAX gene-associated protein isoform X3

      UniProtKB/Swiss-Prot
      A2AWL6, A2AWL7, Q3TS36, Q6A056, Q8BQX1, Q8CCL4, Q9QXJ5
      Conserved Domains (5) summary
      cd00182
      Location:74 → 264
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
      pfam03154
      Location:1619 → 1913
      Atrophin-1; Atrophin-1 family
      pfam16059
      Location:1038 → 1080
      DUF4801; Domain of unknown function (DUF4801)
      pfam17823
      Location:1400 → 1701
      DUF5585; Family of unknown function (DUF5585)
      cd18911
      Location:2342 → 2406
      bHLHzip_MGA; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) and similar proteins

    10. XM_011239590.4 → XP_011237892.1  MAX gene-associated protein isoform X4

      UniProtKB/Swiss-Prot
      A2AWL6, A2AWL7, Q3TS36, Q6A056, Q8BQX1, Q8CCL4, Q9QXJ5
      Conserved Domains (5) summary
      cd00182
      Location:74 → 264
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
      pfam03154
      Location:1570 → 1864
      Atrophin-1; Atrophin-1 family
      pfam16059
      Location:1038 → 1080
      DUF4801; Domain of unknown function (DUF4801)
      pfam17823
      Location:1363 → 1652
      DUF5585; Family of unknown function (DUF5585)
      cd18911
      Location:2293 → 2357
      bHLHzip_MGA; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) and similar proteins

    11. XM_017318962.3 → XP_017174451.1  MAX gene-associated protein isoform X1

      UniProtKB/Swiss-Prot
      A2AWL6, A2AWL7, Q3TS36, Q6A056, Q8BQX1, Q8CCL4, Q9QXJ5
      Conserved Domains (5) summary
      cd00182
      Location:74 → 264
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
      pfam03154
      Location:1729 → 2023
      Atrophin-1; Atrophin-1 family
      pfam16059
      Location:1038 → 1080
      DUF4801; Domain of unknown function (DUF4801)
      pfam17823
      Location:1510 → 1811
      DUF5585; Family of unknown function (DUF5585)
      cd18911
      Location:2452 → 2516
      bHLHzip_MGA; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) and similar proteins

    12. XM_036162282.1 → XP_036018175.1  MAX gene-associated protein isoform X2

      UniProtKB/Swiss-Prot
      A2AWL6, A2AWL7, Q3TS36, Q6A056, Q8BQX1, Q8CCL4, Q9QXJ5
      UniProtKB/TrEMBL
      E9QLG3
      Conserved Domains (4) summary
      pfam05109
      Location:1447 → 1775
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cd18911
      Location:2403 → 2467
      bHLHzip_MGA; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) and similar proteins
      pfam16059
      Location:1038 → 1079
      DUF4801; Domain of unknown function (DUF4801)
      cd20195
      Location:75 → 260
      T-box_MGA-like; DNA-binding domain of MAX gene-associated protein and related T-box proteins

    13. XM_006499698.5 → XP_006499761.1  MAX gene-associated protein isoform X7

      See identical proteins and their annotated locations for XP_006499761.1

      Conserved Domains (3) summary
      pfam05109
      Location:53 → 280
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam03154
      Location:185 → 479
      Atrophin-1; Atrophin-1 family
      cd18911
      Location:908 → 972
      bHLHzip_MGA; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) and similar proteins

    RNA

    1. XR_866291.3 RNA Sequence

    2. XR_004940623.1 RNA Sequence

    3. XR_866290.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2AWL7.1 GenPept UniProtKB/Swiss-Prot:A2AWL7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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