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    Eno3 enolase 3, beta muscle [ Mus musculus (house mouse) ]

    Gene ID: 13808, updated on 23-Dec-2024

    Summary

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    Official Symbol
    Eno3provided by MGI
    Official Full Name
    enolase 3, beta muscleprovided by MGI
    Primary source
    MGI:MGI:95395
    See related
    Ensembl:ENSMUSG00000060600 AllianceGenome:MGI:95395
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MSE; Eno-3
    Summary
    This gene encodes one of the three enolase isoenzymes found in vertebrates. Enolase is a dimeric enzyme that converts 2-phosphoglycerate to phosphoenolpyruvate as part of the glycolytic pathway. This isozyme is found in skeletal muscle where it is involved in muscle development and regeneration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
    Expression
    Biased expression in heart adult (RPKM 242.7), mammary gland adult (RPKM 95.3) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Eno3 in Genome Data Viewer
    Location:
    11 B3; 11 43.21 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (70543973..70553339)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (70653125..70662513)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene glycoprotein 1b, alpha polypeptide Neighboring gene solute carrier family 25 (mitochondrial carrier oxoglutarate carrier), member 11 Neighboring gene STARR-positive B cell enhancer ABC_E1422 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:70460970-70461079 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:70461301-70461410 Neighboring gene STARR-positive B cell enhancer ABC_E7008 Neighboring gene ring finger protein 167 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:70465643-70465931 Neighboring gene STARR-positive B cell enhancer ABC_E3969 Neighboring gene profilin 1 Neighboring gene sperm associated antigen 7 Neighboring gene STARR-positive B cell enhancer ABC_E62 Neighboring gene calmodulin binding transcription activator 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Beta-enolase is a marker of human myoblast heterogeneity prior to differentiation. Peterson CA, et al. Dev Biol, 1992 Jun. PMID 1339335
    2. Interactions of enolase isoforms with tubulin and microtubules during myogenesis. Keller A, et al. Biochim Biophys Acta, 2007 Jun. PMID 17368730
    3. Murine muscle-specific enolase: cDNA cloning, sequence, and developmental expression. Lamandé N, et al. Proc Natl Acad Sci U S A, 1989 Jun. PMID 2734297, Free PMC Article
    4. Conserved alternative splicing in the 5'-untranslated region of the muscle-specific enolase gene. Primary structure of mRNAs, expression and influence of secondary structure on the translation efficiency. Oliva D, et al. Eur J Biochem, 1995 Aug 15. PMID 7556143
    5. Transcriptional up-regulation of the mouse gene for the muscle-specific subunit of enolase during terminal differentiation of myogenic cells. Lamandé N, et al. Mol Reprod Dev, 1995 Jul. PMID 8588929

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphopyruvate hydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphopyruvate hydratase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphopyruvate hydratase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphopyruvate hydratase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in canonical glycolysis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in glycolytic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycolytic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of phosphopyruvate hydratase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of phosphopyruvate hydratase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    beta-enolase
    Names
    2-phospho-D-glycerate hydro-lyase
    muscle-specific enolase
    skeletal muscle enolase
    NP_001129534.1
    NP_001263214.1
    NP_031959.1
    XP_006532224.1
    XP_006532225.1
    XP_030101387.1
    XP_036012183.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136062.3 → NP_001129534.1  beta-enolase

      See identical proteins and their annotated locations for NP_001129534.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AL596117
      Consensus CDS
      CCDS24961.1
      UniProtKB/Swiss-Prot
      P21550
      UniProtKB/TrEMBL
      Q4FK59
      Related
      ENSMUSP00000072620.6, ENSMUST00000072841.12
      Conserved Domains (1) summary
      PLN00191
      Location:2 → 431
      PLN00191; enolase

    2. NM_001276285.2 → NP_001263214.1  beta-enolase

      See identical proteins and their annotated locations for NP_001263214.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AL596117
      Consensus CDS
      CCDS24961.1
      UniProtKB/Swiss-Prot
      P21550
      UniProtKB/TrEMBL
      Q4FK59
      Conserved Domains (1) summary
      PLN00191
      Location:2 → 431
      PLN00191; enolase

    3. NM_001430971.1 → NP_001417900.1  beta-enolase

      Status: VALIDATED

      Source sequence(s)
      AL596117
      UniProtKB/Swiss-Prot
      P21550
      UniProtKB/TrEMBL
      Q4FK59

    4. NM_001430972.1 → NP_001417901.1  beta-enolase

      Status: VALIDATED

      Source sequence(s)
      AL596117
      UniProtKB/Swiss-Prot
      P21550
      UniProtKB/TrEMBL
      Q4FK59

    5. NM_007933.4 → NP_031959.1  beta-enolase

      See identical proteins and their annotated locations for NP_031959.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AL596117
      Consensus CDS
      CCDS24961.1
      UniProtKB/Swiss-Prot
      P21550
      UniProtKB/TrEMBL
      Q4FK59
      Related
      ENSMUSP00000104188.2, ENSMUST00000108548.8
      Conserved Domains (1) summary
      PLN00191
      Location:2 → 431
      PLN00191; enolase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      70543973..70553339
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532161.5 → XP_006532224.1  beta-enolase isoform X1

      See identical proteins and their annotated locations for XP_006532224.1

      UniProtKB/TrEMBL
      Q4FK59
      Conserved Domains (1) summary
      PLN00191
      Location:63 → 517
      PLN00191; enolase

    2. XM_006532162.4 → XP_006532225.1  beta-enolase isoform X2

      See identical proteins and their annotated locations for XP_006532225.1

      UniProtKB/Swiss-Prot
      P21550
      UniProtKB/TrEMBL
      Q4FK59
      Conserved Domains (1) summary
      PLN00191
      Location:2 → 431
      PLN00191; enolase

    3. XM_030245527.2 → XP_030101387.1  beta-enolase isoform X2

      Conserved Domains (1) summary
      PLN00191
      Location:2 → 431
      PLN00191; enolase

    4. XM_036156290.1 → XP_036012183.1  beta-enolase isoform X2

      Conserved Domains (1) summary
      PLN00191
      Location:2 → 431
      PLN00191; enolase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P21550.3 GenPept UniProtKB/Swiss-Prot:P21550

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