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    Pmf1 polyamine-modulated factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 67037, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pmf1provided by MGI
    Official Full Name
    polyamine-modulated factor 1provided by MGI
    Primary source
    MGI:MGI:1914287
    See related
    Ensembl:ENSMUSG00000028066 AllianceGenome:MGI:1914287
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2600009M07Rik
    Summary
    Predicted to enable leucine zipper domain binding activity and transcription coactivator activity. Predicted to be involved in chromosome segregation. Predicted to be located in Golgi apparatus; kinetochore; and nucleoplasm. Predicted to be part of MIS12/MIND type complex. Is expressed in several structures, including central nervous system; extraembryonic component; placenta; retina; and thymus. Human ortholog(s) of this gene implicated in bladder carcinoma and urinary bladder cancer. Orthologous to human PMF1-BGLAP (PMF1-BGLAP readthrough) and PMF1 (polyamine modulated factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 35.3), ovary adult (RPKM 29.6) and 27 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Pmf1 in Genome Data Viewer
    Location:
    3 F1; 3 38.82 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (88301445..88317752, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (88394138..88410445, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene progestin and adipoQ receptor family member 6-like Neighboring gene bone gamma carboxyglutamate protein Neighboring gene solute carrier family 25, member 44 Neighboring gene STARR-positive B cell enhancer ABC_E2076 Neighboring gene 60S ribosomal protein L21 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    General gene information

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in attachment of spindle microtubules to kinetochore PubMed 
    involved_in cell division  
    involved_in chromosome segregation  
    involved_in chromosome segregation  
    involved_in positive regulation of DNA-templated transcription  
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    located_in Golgi apparatus  
    part_of MIS12/MIND type complex  
    part_of MIS12/MIND type complex  
    part_of MIS12/MIND type complex  
    part_of MIS12/MIND type complex PubMed 
    located_in intracellular membrane-bounded organelle  
    located_in kinetochore  
    located_in kinetochore PubMed 
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus PubMed 
    located_in spindle pole PubMed 

    General protein information

    Preferred Names
    polyamine-modulated factor 1
    Names
    PMF-1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310605.2NP_001297534.1  polyamine-modulated factor 1 isoform 2

      See identical proteins and their annotated locations for NP_001297534.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two alternate in-frame exons in the coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC102388
      Consensus CDS
      CCDS79942.1
      UniProtKB/Swiss-Prot
      Q9CPV5
      Related
      ENSMUSP00000141696.2, ENSMUST00000193338.6
      Conserved Domains (1) summary
      pfam03980
      Location:5697
      Nnf1; Nnf1
    2. NM_025928.5NP_080204.1  polyamine-modulated factor 1 isoform 1

      See identical proteins and their annotated locations for NP_080204.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC102388
      Consensus CDS
      CCDS38481.1
      UniProtKB/Swiss-Prot
      Q3UCB8, Q8K237, Q924B3, Q9CPV5, Q9D6E2
      UniProtKB/TrEMBL
      Q8BVG3
      Related
      ENSMUSP00000062420.8, ENSMUST00000056370.13
      Conserved Domains (1) summary
      pfam03980
      Location:68166
      Nnf1; Nnf1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      88301445..88317752 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011240202.3XP_011238504.1  polyamine-modulated factor 1 isoform X1

      UniProtKB/TrEMBL
      Q8BVG3
      Conserved Domains (1) summary
      pfam03980
      Location:68165
      Nnf1
    2. XM_030252766.1XP_030108626.1  polyamine-modulated factor 1 isoform X2

      Conserved Domains (1) summary
      pfam03980
      Location:68119
      Nnf1
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