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    Klra6 killer cell lectin-like receptor, subfamily A, member 6 [ Mus musculus (house mouse) ]

    Gene ID: 16637, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Klra6provided by MGI
    Official Full Name
    killer cell lectin-like receptor, subfamily A, member 6provided by MGI
    Primary source
    MGI:MGI:101902
    See related
    Ensembl:ENSMUSG00000061769 AllianceGenome:MGI:101902
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ly49f; ly-49f
    Summary
    This gene belongs to the highly polymorphic family of C-type lectin-like Ly49 genes that are expressed in natural killer (NK) cells. The encoded protein is a homodimeric type II transmembrane receptor located at the cell surface and inhibits NK cell activation upon ligand binding. This gene is located in a cluster of several Klra paralogs on chromosome 6. Different strains of mice show variation in the number of paralogs, including strain specific duplications, deletions and pseudogene sequences. [provided by RefSeq, Apr 2015]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Klra6 in Genome Data Viewer
    Location:
    6 F3; 6 63.44 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (129989993..130003917, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (130013033..130026960, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40404 Neighboring gene killer cell lectin-like receptor subfamily A, member 13, pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_17483 Neighboring gene killer cell lectin-like receptor, subfamily A, member 4 Neighboring gene predicted gene, 24676

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A new monoclonal antibody reactive with several Ly49 NK cell receptors mediates redirected lysis of target cells. Corral L, et al. Hybridoma, 1999 Aug. PMID 10571266
    2. Multiple cytokines regulate the NK gene complex-encoded receptor repertoire of mature NK cells and T cells. Gays F, et al. J Immunol, 2005 Sep 1. PMID 16116180
    3. Comprehensive analysis of transcript start sites in ly49 genes reveals an unexpected relationship with gene function and a lack of upstream promoters. Gays F, et al. PLoS One, 2011 Mar 31. PMID 21483805, Free PMC Article
    4. Ly-49 multigene family expressed by IL-2-activated NK cells. Smith HR, et al. J Immunol, 1994 Aug 1. PMID 8027540
    5. Inhibitory MHC class I receptors on NK cells and T cells. Lanier LL, et al. Immunol Today, 1996 Feb. PMID 8808056

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    killer cell lectin-like receptor 6
    Names
    T-cell surface glycoprotein Ly-49F
    lymphocyte antigen 49f

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008464.3 → NP_032490.1  killer cell lectin-like receptor 6

      See identical proteins and their annotated locations for NP_032490.1

      Status: VALIDATED

      Source sequence(s)
      AC090563
      Consensus CDS
      CCDS20597.1
      UniProtKB/Swiss-Prot
      Q60653
      Related
      ENSMUSP00000073700.3, ENSMUST00000074056.3
      Conserved Domains (2) summary
      cd03593
      Location:145 → 259
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
      pfam08391
      Location:40 → 157
      Ly49; Ly49-like protein, N-terminal region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      129989993..130003917 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017321417.1 → XP_017176906.1  killer cell lectin-like receptor 6 isoform X2

      Conserved Domains (2) summary
      cd03593
      Location:142 → 256
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
      pfam08391
      Location:40 → 154
      Ly49; Ly49-like protein, N-terminal region
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q60653.1 GenPept UniProtKB/Swiss-Prot:Q60653

    Gene LinkOut

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