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    Banp BTG3 associated nuclear protein [ Mus musculus (house mouse) ]

    Gene ID: 53325, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Banpprovided by MGI
    Official Full Name
    BTG3 associated nuclear proteinprovided by MGI
    Primary source
    MGI:MGI:1889023
    See related
    Ensembl:ENSMUSG00000025316 AllianceGenome:MGI:1889023
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SMAR1
    Summary
    Predicted to enable identical protein binding activity. Involved in positive regulation of DNA-templated transcription. Located in nucleus. Is expressed in bladder; brain; heart; hemolymphoid system gland; and musculature. Orthologous to human BANP (BTG3 associated nuclear protein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 15.5), thymus adult (RPKM 13.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Banp in Genome Data Viewer
    Location:
    8 E1; 8 70.82 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (122674711..122755999)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (121947972..122029260)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9121 Neighboring gene STARR-positive B cell enhancer ABC_E8267 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:124432414-124432597 Neighboring gene solute carrier family 7 (cationic amino acid transporter, y+ system), member 5 Neighboring gene cDNA sequence BC048644 Neighboring gene carbonic anhydrase 5a, mitochondrial Neighboring gene predicted gene, 27011 Neighboring gene ornithine decarboxylase, structural 1 pseudogene Neighboring gene microRNA 7237 Neighboring gene zinc finger protein 469 Neighboring gene STARR-seq mESC enhancer starr_22941 Neighboring gene predicted gene, 34413 Neighboring gene STARR-seq mESC enhancer starr_22942 Neighboring gene predicted gene, 39268

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. SMAR1-derived P44 peptide retains its tumor suppressor function through modulation of p53. Jalota-Badhwar A, et al. J Biol Chem, 2007 Mar 30. PMID 17229733
    2. SMAR1 inhibits proliferation, EMT and Warburg effect of bladder cancer cells by suppressing the activity of the Wnt/β-catenin signaling pathway. Bao P, et al. Cell Cycle, 2023 Jan. PMID 35980125, Free PMC Article
    3. Nuclear matrix binding protein SMAR1 regulates T-cell differentiation and allergic airway disease. Chemmannur SV, et al. Mucosal Immunol, 2015 Nov. PMID 25736456, Free PMC Article
    4. Nuclear matrix protein SMAR1 control regulatory T-cell fate during inflammatory bowel disease (IBD). Mirlekar B, et al. Mucosal Immunol, 2015 Nov. PMID 25993445, Free PMC Article
    5. SMAR1 promotes immune escape of Tri-negative Breast Cancer through a mechanism involving T-bet/PD-1 Axis. Xiaohua W, et al. Cell Mol Biol (Noisy-le-grand), 2018 Sep 30. PMID 30301506

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nuclear Matrix-associated Protein SMAR1 Attenuated Acute Graft-versus-host Disease by Targeting JAK-STAT Signaling in CD4 + T Cells.
      Title: Nuclear Matrix-associated Protein SMAR1 Attenuated Acute Graft-versus-host Disease by Targeting JAK-STAT Signaling in CD4 + T Cells.
    2. SMAR1 inhibits proliferation, EMT and Warburg effect of bladder cancer cells by suppressing the activity of the Wnt/beta-catenin signaling pathway.
      Title: SMAR1 inhibits proliferation, EMT and Warburg effect of bladder cancer cells by suppressing the activity of the Wnt/β-catenin signaling pathway.
    3. Chromatin remodeling protein SMAR1 regulates adipogenesis by modulating the expression of PPARgamma.
      Title: Chromatin remodeling protein SMAR1 regulates adipogenesis by modulating the expression of PPARγ.
    4. BANP opens chromatin and activates CpG-island-regulated genes.
      Title: BANP opens chromatin and activates CpG-island-regulated genes.
    5. SMAR1 downregulation enhances the tumor killing effect of CD8+T cells by activating T-bet and down-regulating PD-1.
      Title: SMAR1 promotes immune escape of Tri-negative Breast Cancer through a mechanism involving T-bet/PD-1 Axis.
    6. SMAR1 transgenic mice exhibited susceptibility to M. tuberculosis infection in vivo irrespective of genetic background. This susceptibility was attributed to downregulation of Th1 response and its hallmark cytokine IFN-gamma
      Title: Constitutive expression of SMAR1 confers susceptibility to Mycobacterium tuberculosis infection in a transgenic mouse model.
    7. This study reveals a critical role of SMAR1 in maintaining the proinflammatory immune responses by repressing Th1 and Th17 cell function and it gives the novel insight into immune regulatory mechanisms.
      Title: Regulation of T cell lineage commitment by SMAR1 during inflammatory & autoimmune diseases.
    8. we report an essential role of the matrix attachment region (MAR)-binding protein SMAR1 in regulating immune response during allergic airway disease
      Title: Nuclear matrix binding protein SMAR1 regulates T-cell differentiation and allergic airway disease.
    9. SMAR1, a known transcription factor and tumor suppressor, is directly involved in maintaining regulatory T cell fate decision
      Title: Nuclear matrix protein SMAR1 control regulatory T-cell fate during inflammatory bowel disease (IBD).
    10. Glucose deprivation can induce p53 internal ribosome entry sites (IRESs) and also increases cytoplasmic abundance of SMAR1 that in turn binds to p53 IRESs, indicating the role of SMAR1 in controlling translation of p53 isoforms.
      Title: Reversible induction of translational isoforms of p53 in glucose deprivation.
    Submit: New GeneRIF Correction See all GeneRIFs (17)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein BANP
    Names
    scaffold/matrix-associated region-1-binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110100.2 → NP_001103570.1  protein BANP isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) uses an alternate splice site in the coding region compared to variant 2. The resulting protein (isoform 1) is shorter but has the same N- and C-termini compared to isoform 2.
      Source sequence(s)
      AC116772, BC062641, CX207431, DV661446
      UniProtKB/Swiss-Prot
      Q8VBU8
      Conserved Domains (1) summary
      smart01025
      Location:257 → 330
      BEN; The BEN domain is found in diverse animal proteins

    2. NM_001285981.1 → NP_001272910.1  protein BANP isoform 3

      See identical proteins and their annotated locations for NP_001272910.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the coding region compared to variant 2. The resulting protein (isoform 3) is shorter but has the same N- and C-termini compared to isoform 2.
      Source sequence(s)
      AC116772, BC062641, CX207431
      Consensus CDS
      CCDS72176.1
      UniProtKB/Swiss-Prot
      Q8VBU8
      Related
      ENSMUSP00000026354.9, ENSMUST00000026354.15
      Conserved Domains (1) summary
      smart01025
      Location:218 → 291
      BEN; The BEN domain is found in diverse animal proteins

    3. NM_001285983.1 → NP_001272912.1  protein BANP isoform 4

      See identical proteins and their annotated locations for NP_001272912.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon and uses an alternate splice site in the coding region compared to variant 2. The resulting protein (isoform 4) is shorter but has the same N- and C-termini compared to isoform 2.
      Source sequence(s)
      AC116772, AF235503, CX207431, DV661446
      Consensus CDS
      CCDS72177.1
      UniProtKB/Swiss-Prot
      Q8VBU8
      Related
      ENSMUSP00000090766.7, ENSMUST00000093078.13
      Conserved Domains (1) summary
      smart01025
      Location:218 → 291
      BEN; The BEN domain is found in diverse animal proteins

    4. NM_001413724.1 → NP_001400653.1  protein BANP isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC116772

    5. NM_001413725.1 → NP_001400654.1  protein BANP isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC116772

    6. NM_001413726.1 → NP_001400655.1  protein BANP isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC116772

    7. NM_001413727.1 → NP_001400656.1  protein BANP isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC116772

    8. NM_001413728.1 → NP_001400657.1  protein BANP isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC116772

    9. NM_001413729.1 → NP_001400658.1  protein BANP isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC116772

    10. NM_001413730.1 → NP_001400659.1  protein BANP isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC116772

    11. NM_001413731.1 → NP_001400660.1  protein BANP isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC116772
      Related
      ENSMUSP00000132434.3, ENSMUST00000167711.9

    12. NM_016812.4 → NP_058092.2  protein BANP isoform 2

      See identical proteins and their annotated locations for NP_058092.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longest transcript and encodes the longest protein (isoform 2).
      Source sequence(s)
      AC116772, BC062641, CX207431
      Consensus CDS
      CCDS40502.1
      UniProtKB/Swiss-Prot
      O88973, Q3U4R5, Q8VBU8, Q91YZ1, Q9ES51
      Related
      ENSMUSP00000132095.2, ENSMUST00000170857.8
      Conserved Domains (1) summary
      smart01025
      Location:257 → 330
      BEN; The BEN domain is found in diverse animal proteins

    RNA

    1. NR_182207.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC116772

    2. NR_182208.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC116772

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      122674711..122755999
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017312899.2 → XP_017168388.1  protein BANP isoform X1

      UniProtKB/Swiss-Prot
      O88973, Q3U4R5, Q8VBU8, Q91YZ1, Q9ES51
      Conserved Domains (1) summary
      smart01025
      Location:257 → 330
      BEN; The BEN domain is found in diverse animal proteins

    2. XM_011248442.1 → XP_011246744.1  protein BANP isoform X2

      UniProtKB/Swiss-Prot
      Q8VBU8
      Related
      ENSMUSP00000133783.2, ENSMUST00000173254.8
      Conserved Domains (1) summary
      smart01025
      Location:257 → 330
      BEN; The BEN domain is found in diverse animal proteins

    3. XM_030243675.2 → XP_030099535.1  protein BANP isoform X6

      Conserved Domains (1) summary
      smart01025
      Location:116 → 189
      BEN; The BEN domain is found in diverse animal proteins

    4. XM_030243674.2 → XP_030099534.1  protein BANP isoform X5

      Conserved Domains (1) summary
      smart01025
      Location:116 → 189
      BEN; The BEN domain is found in diverse animal proteins

    5. XM_011248445.1 → XP_011246747.1  protein BANP isoform X7

      UniProtKB/TrEMBL
      F6V6B6
      Conserved Domains (1) summary
      smart01025
      Location:23 → 96
      BEN; The BEN domain is found in diverse animal proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VBU8.1 GenPept UniProtKB/Swiss-Prot:Q8VBU8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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