Psma3 proteasome subunit alpha 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Psma3provided by MGI
Official Full Name: proteasome subunit alpha 3provided by MGI
Primary source: MGI:MGI:104883
See related: Ensembl:ENSMUSG00000060073 AllianceGenome:MGI:104883
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Lmpc8
Summary: Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and regulation of endopeptidase activity. Part of proteasome core complex. Is expressed in several structures, including central nervous system; cranium; dorsal root ganglion; lung; and tooth. Orthologous to human PSMA3 (proteasome 20S subunit alpha 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in placenta adult (RPKM 35.7), CNS E11.5 (RPKM 28.9) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 C2; 12 29.39 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (71016082..71042651)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (70969283..70995877)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Protein interaction between Ambn and Psma3 can facilitate redistribution of ameloblastin domains within forming enamel.
Title: Protein Interaction between Ameloblastin and Proteasome Subunit α Type 3 Can Facilitate Redistribution of Ameloblastin Domains within Forming Enamel.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of endopeptidase activity	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
part_of proteasome complex	ISO Inferred from Sequence Orthology more info
part_of proteasome core complex	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome core complex	ISO Inferred from Sequence Orthology more info
part_of proteasome core complex, alpha-subunit complex	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome core complex, alpha-subunit complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: proteasome subunit alpha type-3

Names: alpha-7; macropain subunit C8; multicatalytic endopeptidase complex subunit C8; proteasome (prosome, macropain) subunit, alpha type 3; proteasome component C8; proteasome subunit K; proteasome subunit alpha-7

NP_001297524.1

EC 3.4.25.1

NP_001297525.1

EC 3.4.25.1

NP_001409967.1

EC 3.4.25.1

NP_001409969.1

EC 3.4.25.1

NP_001409970.1

EC 3.4.25.1

NP_001409971.1

EC 3.4.25.1

NP_001409974.1

EC 3.4.25.1

NP_035314.3

EC 3.4.25.1

XP_036013150.1

EC 3.4.25.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001310595.1 → NP_001297524.1 proteasome subunit alpha type-3 isoform b

See identical proteins and their annotated locations for NP_001297524.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' structure, lacks a portion of the 5' coding region, and initiates translation at a downstream start site, compared to variant 1. The encoded isoform (b) has a shorter N-terminus compared to isoform a. Variants 2 and 3 encode the same isoform.

Source sequence(s)

AC132325, AI303320, AK169577, BY159585

Consensus CDS

CCDS79119.1

UniProtKB/TrEMBL

E0CX62, Q3TEL1

Related

ENSMUSP00000124894.3, ENSMUST00000160864.8

Conserved Domains (1) summary

cl00467
Location:1 → 142

Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...
NM_001310596.1 → NP_001297525.1 proteasome subunit alpha type-3 isoform b

See identical proteins and their annotated locations for NP_001297525.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' structure, lacks a portion of the 5' coding region, and initiates translation at a downstream start site, compared to variant 1. The encoded isoform (b) has a shorter N-terminus compared to isoform a. Variants 2 and 3 encode the same isoform.

Source sequence(s)

AC132325

Consensus CDS

CCDS79119.1

UniProtKB/TrEMBL

E0CX62, Q3TEL1

Conserved Domains (1) summary

cl00467
Location:1 → 142

Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...
NM_001423038.1 → NP_001409967.1 proteasome subunit alpha type-3 isoform a

Status: VALIDATED

Source sequence(s)

AC132325

UniProtKB/Swiss-Prot

O70435

UniProtKB/TrEMBL

Q58EV4
NM_001423040.1 → NP_001409969.1 proteasome subunit alpha type-3 isoform b

Status: VALIDATED

Source sequence(s)

AC132325

UniProtKB/TrEMBL

E0CX62
NM_001423041.1 → NP_001409970.1 proteasome subunit alpha type-3 isoform c

Status: VALIDATED

Source sequence(s)

AC132325
NM_001423042.1 → NP_001409971.1 proteasome subunit alpha type-3 isoform c

Status: VALIDATED

Source sequence(s)

AC132325
NM_001423045.1 → NP_001409974.1 proteasome subunit alpha type-3 isoform a

Status: VALIDATED

Source sequence(s)

AC132325

UniProtKB/Swiss-Prot

O70435

UniProtKB/TrEMBL

Q58EV4
NM_011184.5 → NP_035314.3 proteasome subunit alpha type-3 isoform a

See identical proteins and their annotated locations for NP_035314.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).

Source sequence(s)

AC132325, AI303320, AK168495, BY159585

Consensus CDS

CCDS25961.1

UniProtKB/Swiss-Prot

O70435

UniProtKB/TrEMBL

Q58EV4, Q9DCD8

Related

ENSMUSP00000125548.2, ENSMUST00000160027.8

Conserved Domains (1) summary

cd03751
Location:5 → 217

proteasome_alpha_type_3; The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

71016082..71042651

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036157257.1 → XP_036013150.1 proteasome subunit alpha type-3 isoform X2

UniProtKB/TrEMBL

Q9DCD8

Conserved Domains (1) summary

cd03751
Location:5 → 195

proteasome_alpha_type_3; The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming ...