Mpp1 membrane protein, palmitoylated [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mpp1provided by MGI
Official Full Name: membrane protein, palmitoylatedprovided by MGI
Primary source: MGI:MGI:105941
See related: Ensembl:ENSMUSG00000031402 AllianceGenome:MGI:105941
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: p55; 55kDa; C130070C03Rik
Summary: This gene encodes a protein localized to the cell membrane. The protein serves as a scaffold for the assembly of the actin cytoskeleton, and plays a role in regulating apico-basal cell polarity. [provided by RefSeq, May 2015]
Expression: Ubiquitous expression in large intestine adult (RPKM 47.7), liver E14 (RPKM 39.1) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: X A7.3; X 38.15 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (74153339..74174622, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (75109733..75131016, complement)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gelsolin was identified as the additional interacting partners to p55 in the whirlin interactome of hair cell stereocilia.
Title: Gelsolin plays a role in the actin polymerization complex of hair cell stereocilia.
Results show that p55 is required for neutrophil polarization by regulating Akt phosphorylation through a mechanism that is independent of PI3Kgamma activity.
Title: Erythrocyte scaffolding protein p55/MPP1 functions as an essential regulator of neutrophil polarity.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in regulation of neutrophil chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cell-cell junction	IBA Inferred from Biological aspect of Ancestor more info
located_in centriolar satellite	IEA Inferred from Electronic Annotation more info
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
located_in cortical cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in stereocilium	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: 55 kDa erythrocyte membrane protein

Names: erythrocyte protein p55; membrane protein, palmitoylated 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008621.3 → NP_032647.1 55 kDa erythrocyte membrane protein

See identical proteins and their annotated locations for NP_032647.1

Status: REVIEWED

Source sequence(s)

AK048532, AK081829

Consensus CDS

CCDS30236.1

UniProtKB/Swiss-Prot

P70290

UniProtKB/TrEMBL

B7ZCL8, Q542P4

Related

ENSMUSP00000033775.3, ENSMUST00000033775.9

Conserved Domains (4) summary

cd12080
Location:162 → 223

SH3_MPP1; Src Homology 3 domain of Membrane Protein, Palmitoylated 1 (or MAGUK p55 subfamily member 1)

smart00072
Location:291 → 454

GuKc; Guanylate kinase homologues

pfam00595
Location:71 → 149

PDZ; PDZ domain (Also known as DHR or GLGF)

pfam00625
Location:281 → 453

Guanylate_kin; Guanylate kinase