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    Man1a mannosidase 1, alpha [ Mus musculus (house mouse) ]

    Gene ID: 17155, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Man1aprovided by MGI
    Official Full Name
    mannosidase 1, alphaprovided by MGI
    Primary source
    MGI:MGI:104677
    See related
    Ensembl:ENSMUSG00000003746 AllianceGenome:MGI:104677
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PCR1; Man1a1
    Summary
    Predicted to enable mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Predicted to be involved in mannose trimming involved in glycoprotein ERAD pathway and protein targeting to ER. Located in Golgi membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hindlimb mesenchyme; and sensory organ. Orthologous to human MAN1A1 (mannosidase alpha class 1A member 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in genital fat pad adult (RPKM 59.2), liver adult (RPKM 19.3) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Man1a in Genome Data Viewer
    Location:
    10 B3; 10 27.4 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (53780881..53952712, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (53904785..54076616, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6844 Neighboring gene minichromosome maintenance 9 homologous recombination repair factor Neighboring gene STARR-positive B cell enhancer ABC_E10606 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:53349966-53350075 Neighboring gene anti-silencing function 1A histone chaperone Neighboring gene family with sequence similarity 184, member A Neighboring gene STARR-positive B cell enhancer mm9_chr10:53704763-53705064 Neighboring gene STARR-positive B cell enhancer ABC_E6845 Neighboring gene STARR-positive B cell enhancer mm9_chr10:53735714-53736015 Neighboring gene predicted gene, 53584 Neighboring gene STARR-positive B cell enhancer mm9_chr10:53795485-53795786 Neighboring gene STARR-positive B cell enhancer ABC_E6848 Neighboring gene STARR-positive B cell enhancer ABC_E6849 Neighboring gene predicted gene, 16998 Neighboring gene STARR-seq mESC enhancer starr_26701 Neighboring gene predicted gene, 40651 Neighboring gene STARR-seq mESC enhancer starr_26702 Neighboring gene predicted gene, 26177

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Substrate recognition and catalysis by GH47 α-mannosidases involved in Asn-linked glycan maturation in the mammalian secretory pathway. Xiang Y, et al. Proc Natl Acad Sci U S A, 2016 Dec 6. PMID 27856750, Free PMC Article
    2. Differential expression and function of α-mannosidase I in stimulated naive and memory CD4+ T cells. Gebuhr I, et al. J Immunother, 2011 Jun. PMID 21577142
    3. Structure of mouse Golgi alpha-mannosidase IA reveals the molecular basis for substrate specificity among class 1 (family 47 glycosylhydrolase) alpha1,2-mannosidases. Tempel W, et al. J Biol Chem, 2004 Jul 9. PMID 15102839
    4. Isolation of a mouse Golgi mannosidase cDNA, a member of a gene family conserved from yeast to mammals. Herscovics A, et al. J Biol Chem, 1994 Apr 1. PMID 8144579
    5. Isolation and expression of murine and rabbit cDNAs encoding an alpha 1,2-mannosidase involved in the processing of asparagine-linked oligosaccharides. Lal A, et al. J Biol Chem, 1994 Apr 1. PMID 8144580

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. in the bound substrate complex, hydrophobic stacking interactions between Trp residues and the glycan core anchor the base of the glycan structure to the enzyme cleft
      Title: Substrate recognition and catalysis by GH47 α-mannosidases involved in Asn-linked glycan maturation in the mammalian secretory pathway.
    2. Complex N-glycans generated by enzymes such as a-mannosidase I inhibit the activation of naive T cells.
      Title: Differential expression and function of α-mannosidase I in stimulated naive and memory CD4+ T cells.
    3. Data report the crystallization of murine Golgi mannosidase IA and the structural solution to 1.5-A resolution by molecular replacement
      Title: Structure of mouse Golgi alpha-mannosidase IA reveals the molecular basis for substrate specificity among class 1 (family 47 glycosylhydrolase) alpha1,2-mannosidases.
    4. Downregulation of TOAG-1 and alpha-1,2-mannosidase expression occurred in graft infiltrating cells and expression of both genes was also downregulated after T-cell activation in vitro
      Title: Identification of gene markers for the prediction of allograft rejection or permanent acceptance.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mannose trimming involved in glycoprotein ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein targeting to ER ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mannosyl-oligosaccharide 1,2-alpha-mannosidase IA
    Names
    alpha-1,2-mannosidase IA
    man(9)-alpha-mannosidase
    man9-mannosidase
    mannosidase alpha class 1A member 1
    mannosyl-oligosaccharide alpha-1,2-mannosidase
    processing alpha-1,2-mannosidase IA
    NP_032574.1
    XP_006512631.1
    XP_006512632.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008548.5 → NP_032574.1  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA

      See identical proteins and their annotated locations for NP_032574.1

      Status: VALIDATED

      Source sequence(s)
      AC153816, AC158642, AC164624
      Consensus CDS
      CCDS23848.1
      UniProtKB/Swiss-Prot
      P45700
      UniProtKB/TrEMBL
      A0A1W2P788, Q544T7
      Related
      ENSMUSP00000003843.9, ENSMUST00000003843.16
      Conserved Domains (2) summary
      pfam01532
      Location:204 → 642
      Glyco_hydro_47; Glycosyl hydrolase family 47
      cl39091
      Location:87 → 214
      SdhA; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      53780881..53952712 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512568.3 → XP_006512631.1  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA isoform X1

      UniProtKB/TrEMBL
      A0A1W2P788
      Related
      ENSMUSP00000151568.2, ENSMUST00000220088.2
      Conserved Domains (2) summary
      pfam01532
      Location:295 → 733
      Glyco_hydro_47; Glycosyl hydrolase family 47
      cl39091
      Location:178 → 305
      SdhA; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]

    2. XM_006512569.5 → XP_006512632.1  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA isoform X2

      See identical proteins and their annotated locations for XP_006512632.1

      UniProtKB/Swiss-Prot
      P45700
      UniProtKB/TrEMBL
      A0A1W2P788, Q544T7
      Related
      ENSMUSP00000101110.2, ENSMUST00000105470.9
      Conserved Domains (2) summary
      pfam01532
      Location:204 → 642
      Glyco_hydro_47; Glycosyl hydrolase family 47
      cl39091
      Location:87 → 214
      SdhA; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]

    RNA

    1. XR_001779471.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P45700.1 GenPept UniProtKB/Swiss-Prot:P45700

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