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    Nr3c2 nuclear receptor subfamily 3, group C, member 2 [ Mus musculus (house mouse) ]

    Gene ID: 110784, updated on 3-Dec-2024

    Summary

    Official Symbol
    Nr3c2provided by MGI
    Official Full Name
    nuclear receptor subfamily 3, group C, member 2provided by MGI
    Primary source
    MGI:MGI:99459
    See related
    Ensembl:ENSMUSG00000031618 AllianceGenome:MGI:99459
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MR; Mlr
    Summary
    Enables steroid binding activity. Involved in several processes, including angiotensin-activated signaling pathway; regulation of blood volume by renal aldosterone; and regulation of potassium:proton exchanging ATPase activity. Acts upstream of or within intracellular sodium ion homeostasis and renal sodium excretion. Is active in GABA-ergic synapse and glutamatergic synapse. Is expressed in several structures, including central nervous system; genitourinary system; intestine; and trophectoderm. Used to study autosomal dominant pseudohypoaldosteronism type 1. Human ortholog(s) of this gene implicated in autosomal dominant pseudohypoaldosteronism type 1 and pseudohypoaldosteronism. Orthologous to human NR3C2 (nuclear receptor subfamily 3 group C member 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in colon adult (RPKM 12.0), frontal lobe adult (RPKM 3.4) and 20 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Nr3c2 in Genome Data Viewer
    Location:
    8 C1; 8 36.34 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (77626422..77971641)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (76898083..77245012)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene 10649 Neighboring gene predicted gene, 57499 Neighboring gene STARR-seq mESC enhancer starr_21947 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene predicted gene, 24838 Neighboring gene predicted gene, 23260 Neighboring gene Rho GTPase activating protein 10 Neighboring gene STARR-seq mESC enhancer starr_21951 Neighboring gene STARR-seq mESC enhancer starr_21952 Neighboring gene STARR-seq mESC enhancer starr_21953 Neighboring gene predicted gene 45407 Neighboring gene STARR-seq mESC enhancer starr_21954 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:79946917-79947070 Neighboring gene RIKEN cDNA 0610038B21 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (4) 
    • Targeted (7)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables TBP-class protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables estrogen response element binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables histone acetyltransferase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nuclear receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables nuclear steroid receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables steroid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables steroid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coactivator binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in angiotensin-activated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to aldosterone ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within intracellular sodium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in locomotory behavior ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nuclear receptor-mediated corticosteroid signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nuclear receptor-mediated steroid hormone signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of non-canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in potassium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in presynaptic modulation of chemical synaptic transmission EXP
    Inferred from Experiment
    more info
    PubMed 
    involved_in presynaptic modulation of chemical synaptic transmission IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of blood volume by renal aldosterone IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of postsynaptic membrane potential EXP
    Inferred from Experiment
    more info
    PubMed 
    involved_in regulation of postsynaptic membrane potential IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of potassium:proton exchanging ATPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within renal sodium excretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to corticosterone ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in GABA-ergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in glutamatergic synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic density, intracellular component ISO
    Inferred from Sequence Orthology
    more info
     
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in presynaptic active zone cytoplasmic component ISO
    Inferred from Sequence Orthology
    more info
     
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    mineralocorticoid receptor
    Names
    aldosterone receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083906.3NP_001077375.1  mineralocorticoid receptor

      See identical proteins and their annotated locations for NP_001077375.1

      Status: VALIDATED

      Source sequence(s)
      AC116768, AC118019, AC119248
      Consensus CDS
      CCDS40393.1
      UniProtKB/Swiss-Prot
      Q8VII8, Q8VII9
      UniProtKB/TrEMBL
      A3KN90
      Related
      ENSMUSP00000105538.2, ENSMUST00000109912.8
      Conserved Domains (3) summary
      cd07075
      Location:733980
      NR_LBD_MR; Ligand binding domain of the mineralocorticoid receptor, a member of the nuclear receptor superfamily
      cd07172
      Location:599673
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam05109
      Location:200394
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    2. NM_001426575.1NP_001413504.1  mineralocorticoid receptor

      Status: VALIDATED

      Source sequence(s)
      AC116768, AC118019, AC119248
      UniProtKB/Swiss-Prot
      Q8VII8, Q8VII9
      UniProtKB/TrEMBL
      A3KN90
    3. NM_001426576.1NP_001413505.1  mineralocorticoid receptor

      Status: VALIDATED

      Source sequence(s)
      AC116768, AC118019, AC119248
      UniProtKB/Swiss-Prot
      Q8VII8, Q8VII9
      UniProtKB/TrEMBL
      A3KN90
      Related
      ENSMUSP00000034031.6, ENSMUST00000034031.6
    4. NM_001426577.1NP_001413506.1  mineralocorticoid receptor

      Status: VALIDATED

      Source sequence(s)
      AC116768, AC118019, AC119248
      UniProtKB/Swiss-Prot
      Q8VII8, Q8VII9
      UniProtKB/TrEMBL
      A3KN90
    5. NM_001426578.1NP_001413507.1  mineralocorticoid receptor

      Status: VALIDATED

      Source sequence(s)
      AC116768, AC118019, AC119248
      UniProtKB/Swiss-Prot
      Q8VII8, Q8VII9
      UniProtKB/TrEMBL
      A3KN90
      Related
      ENSMUSP00000105539.3, ENSMUST00000109913.9

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      77626422..77971641
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153720.1XP_036009613.1  mineralocorticoid receptor isoform X2

      UniProtKB/TrEMBL
      D6RIL1
      Related
      ENSMUSP00000118222.2, ENSMUST00000148106.8
      Conserved Domains (2) summary
      cd07172
      Location:599671
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
      pfam15921
      Location:112308
      CCDC158; Coiled-coil domain-containing protein 158