Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Pank3 pantothenate kinase 3 [ Mus musculus (house mouse) ]

    Gene ID: 211347, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pank3provided by MGI
    Official Full Name
    pantothenate kinase 3provided by MGI
    Primary source
    MGI:MGI:2387464
    See related
    Ensembl:ENSMUSG00000018846 AllianceGenome:MGI:2387464
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables pantothenate kinase activity. Acts upstream of or within coenzyme A biosynthetic process. Located in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human PANK3 (pantothenate kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in subcutaneous fat pad adult (RPKM 15.7), genital fat pad adult (RPKM 13.8) and 27 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Pank3 in Genome Data Viewer
    Location:
    11 A4; 11 21.96 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (35660322..35682112)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (35769495..35791285)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene slit guidance ligand 3 Neighboring gene microRNA 218-2 Neighboring gene predicted gene, 46278 Neighboring gene STARR-positive B cell enhancer ABC_E1137 Neighboring gene STARR-positive B cell enhancer ABC_E9361 Neighboring gene microRNA 103-1 Neighboring gene fibrillarin-like 1 Neighboring gene arginyl-tRNA synthetase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC38148

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables acetyl-CoA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables acetyl-CoA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables pantothenate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables pantothenate kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables pantothenate kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables pantothenate kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables vitamin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables vitamin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in coenzyme A biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within coenzyme A biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in coenzyme A biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in coenzyme A biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    pantothenate kinase 3
    Names
    mPanK3
    pantothenic acid kinase 3
    NP_666074.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145962.2NP_666074.1  pantothenate kinase 3

      See identical proteins and their annotated locations for NP_666074.1

      Status: VALIDATED

      Source sequence(s)
      AK039865, AL596084, CD541217, CJ127650
      Consensus CDS
      CCDS24543.1
      UniProtKB/Swiss-Prot
      Q8R2W9
      UniProtKB/TrEMBL
      Q5SXA7, Q7M752
      Related
      ENSMUSP00000018990.8, ENSMUST00000018990.8
      Conserved Domains (1) summary
      pfam03630
      Location:14362
      Fumble

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      35660322..35682112
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)