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    Tmprss2 transmembrane protease, serine 2 [ Mus musculus (house mouse) ]

    Gene ID: 50528, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tmprss2provided by MGI
    Official Full Name
    transmembrane protease, serine 2provided by MGI
    Primary source
    MGI:MGI:1354381
    See related
    Ensembl:ENSMUSG00000000385 AllianceGenome:MGI:1354381
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D16Ertd61e
    Summary
    Predicted to enable serine-type endopeptidase activity. Involved in proteolysis. Predicted to be located in nucleoplasm and plasma membrane. Is expressed in several structures, including brain; extraembryonic component; genitourinary system; gut; and respiratory system. Orthologous to human TMPRSS2 (transmembrane serine protease 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in bladder adult (RPKM 149.8), colon adult (RPKM 109.6) and 8 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Tmprss2 in Genome Data Viewer
    Location:
    16 C4; 16 57.53 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (97365882..97460741, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (97564682..97659541, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene FAM3 metabolism regulating signaling molecule B Neighboring gene STARR-seq mESC enhancer starr_41630 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_41631 Neighboring gene STARR-seq mESC enhancer starr_41632 Neighboring gene MX dynamin-like GTPase 2 Neighboring gene STARR-positive B cell enhancer mm9_chr16:97814757-97815058 Neighboring gene STARR-seq mESC enhancer starr_41635 Neighboring gene predicted gene, 41512 Neighboring gene predicted gene, 41513

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (10) 
    • Targeted (10)  1 citation

    General gene information

    Markers

    Clone Names

    • MGC6821

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables serine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in positive regulation of viral entry into host cell ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of viral entry into host cell ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein autoprocessing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein autoprocessing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein autoprocessing ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    transmembrane protease serine 2
    Names
    epitheliasin
    plasmic transmembrane protein X
    NP_056590.2
    XP_006523127.1
    XP_006523128.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015775.2NP_056590.2  transmembrane protease serine 2

      See identical proteins and their annotated locations for NP_056590.2

      Status: PROVISIONAL

      Source sequence(s)
      BC054348
      Consensus CDS
      CCDS37417.1
      UniProtKB/Swiss-Prot
      Q7TN04, Q9JIQ8, Q9JKC4, Q9QY82
      UniProtKB/TrEMBL
      Q3UKE3
      Related
      ENSMUSP00000000395.7, ENSMUST00000000395.8
      Conserved Domains (3) summary
      cd00112
      Location:112147
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd00190
      Location:254485
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam15494
      Location:152247
      SRCR_2; Scavenger receptor cysteine-rich domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      97365882..97460741 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006523064.3XP_006523127.1  transmembrane protease serine 2 isoform X1

      See identical proteins and their annotated locations for XP_006523127.1

      UniProtKB/Swiss-Prot
      Q7TN04, Q9JIQ8, Q9JKC4, Q9QY82
      UniProtKB/TrEMBL
      Q3UKE3
      Conserved Domains (3) summary
      cd00112
      Location:112147
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd00190
      Location:254485
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam15494
      Location:152247
      SRCR_2; Scavenger receptor cysteine-rich domain
    2. XM_006523065.2XP_006523128.1  transmembrane protease serine 2 isoform X1

      See identical proteins and their annotated locations for XP_006523128.1

      UniProtKB/Swiss-Prot
      Q7TN04, Q9JIQ8, Q9JKC4, Q9QY82
      UniProtKB/TrEMBL
      Q3UKE3
      Conserved Domains (3) summary
      cd00112
      Location:112147
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd00190
      Location:254485
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam15494
      Location:152247
      SRCR_2; Scavenger receptor cysteine-rich domain