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    TRUB1 TruB pseudouridine synthase family member 1 [ Homo sapiens (human) ]

    Gene ID: 142940, updated on 9-Dec-2024

    Summary

    Official Symbol
    TRUB1provided by HGNC
    Official Full Name
    TruB pseudouridine synthase family member 1provided by HGNC
    Primary source
    HGNC:HGNC:16060
    See related
    Ensembl:ENSG00000165832 MIM:610726; AllianceGenome:HGNC:16060
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PUS4
    Summary
    Pseudouridine is an abundant component of rRNAs and tRNAs and is enzymatically generated by isomerization of uridine by pseudouridine synthase (Zucchini et al., 2003 [PubMed 12736709]).[supplied by OMIM, Mar 2008]
    Expression
    Ubiquitous expression in adrenal (RPKM 19.3), testis (RPKM 13.5) and 24 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See TRUB1 in Genome Data Viewer
    Location:
    10q25.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (114938195..114977676)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (115832499..115871976)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (116697954..116737435)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene translation initiation factor IF-2-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2846 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2847 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:116581943-116582443 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4092 Neighboring gene FHF complex subunit HOOK interacting protein 2A Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:116640543-116641171 Neighboring gene Sharpr-MPRA regulatory region 3306 Neighboring gene ribosomal protein L15 pseudogene 13 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4093 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2849 Neighboring gene MPRA-validated peak1102 silencer Neighboring gene RNA, U6 small nuclear 1121, pseudogene Neighboring gene long intergenic non-protein coding RNA 2626 Neighboring gene uncharacterized LOC107984272 Neighboring gene uncharacterized LOC124902509

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables pre-miRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables pseudouridine synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables pseudouridine synthase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables tRNA pseudouridine(55) synthase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mRNA pseudouridine synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mRNA pseudouridine synthesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of pre-miRNA processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in tRNA modification IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in tRNA modification IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion HTP PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    pseudouridylate synthase TRUB1
    Names
    TruB pseudouridine (psi) synthase family member 1
    TruB pseudouridine (psi) synthase homolog 1
    probable tRNA pseudouridine synthase 1
    psi55 synthase TRUB1
    tRNA pseudouridine 55 synthase TRUB1
    truB pseudouridine synthase homolog 1
    NP_631908.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_139169.5NP_631908.1  pseudouridylate synthase TRUB1

      See identical proteins and their annotated locations for NP_631908.1

      Status: VALIDATED

      Source sequence(s)
      AL355340, BC030601
      Consensus CDS
      CCDS7591.1
      UniProtKB/Swiss-Prot
      B2R716, Q53ES2, Q8WWH5
      Related
      ENSP00000298746.3, ENST00000298746.5
      Conserved Domains (1) summary
      cd02867
      Location:70348
      PseudoU_synth_TruB_4; Pseudouridine synthase homolog 4

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      114938195..114977676
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      115832499..115871976
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)