GABBR1 gamma-aminobutyric acid type B receptor subunit 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: GABBR1provided by HGNC
Official Full Name: gamma-aminobutyric acid type B receptor subunit 1provided by HGNC
Primary source: HGNC:HGNC:4070
See related: Ensembl:ENSG00000204681 MIM:603540; AllianceGenome:HGNC:4070
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GB1; NEDLC; GPRC3A; GABABR1; GABBR1-3
Summary: This gene encodes a receptor for gamma-aminobutyric acid (GABA), which is the main inhibitory neurotransmitter in the mammalian central nervous system. This receptor functions as a heterodimer with GABA(B) receptor 2. Defects in this gene may underlie brain disorders such as schizophrenia and epilepsy. Alternative splicing generates multiple transcript variants, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jan 2016]
Expression: Broad expression in brain (RPKM 72.0), spleen (RPKM 14.7) and 15 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 6p22.1

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (29602238..29633183, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (29476949..29507887, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (29570015..29600960, complement)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GABBR1 monoallelic de novo variants linked to neurodevelopmental delay and epilepsy.
Title: GABBR1 monoallelic de novo variants linked to neurodevelopmental delay and epilepsy.
Phosphonate-Modified Cellulose Nanocrystals Potentiate the Th1 Polarising Capacity of Monocyte-Derived Dendritic Cells via GABA-B Receptor.
Title: Phosphonate-Modified Cellulose Nanocrystals Potentiate the Th1 Polarising Capacity of Monocyte-Derived Dendritic Cells via GABA-B Receptor.
Adipose-derived stem cell-derived extracellular vesicles inhibit neuroblastoma growth by regulating GABBR1 activity through LINC00622-mediated transcription factor AR.
Title: Adipose-derived stem cell-derived extracellular vesicles inhibit neuroblastoma growth by regulating GABBR1 activity through LINC00622-mediated transcription factor AR.
The neurotransmitter receptor Gabbr1 regulates proliferation and function of hematopoietic stem and progenitor cells.
Title: The neurotransmitter receptor Gabbr1 regulates proliferation and function of hematopoietic stem and progenitor cells.
Structural Basis for Activation of the Heterodimeric GABAB Receptor.
Title: Structural Basis for Activation of the Heterodimeric GABA(B) Receptor.
Structure of human GABAB receptor in an inactive state.
Title: Structure of human GABA(B) receptor in an inactive state.
Structures of metabotropic GABAB receptor.
Title: Structures of metabotropic GABA(B) receptor.
Structural basis of the activation of a metabotropic GABA receptor.
Title: Structural basis of the activation of a metabotropic GABA receptor.
In a Chinese population, the C allele frequency of rs715044 of the GABBR1 gene was associated with methamphetamine use disorder.
Title: Variants in GABBR1 Gene Are Associated with Methamphetamine Dependence and Two Years' Relapse after Drug Rehabilitation.
GABA B receptor expression in myometrium
Title: Profiling of GABA(A) and GABA(B) receptor expression in the myometrium of the human uterus.

Submit: New GeneRIF Correction See all GeneRIFs (81)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Neurodevelopmental disorder with language delay and variable cognitive abnormalities MedGen: C5882689 OMIM: 620502 GeneReviews: Not available	not available

EBI GWAS Catalog

Description
A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study reveals multiple nasopharyngeal carcinoma-associated loci within the HLA region at chromosome 6p21.3. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH63712 (e-PCR)
- UniSTS:70971

G19983 (e-PCR)
- UniSTS:16221

WI-12368 (e-PCR)
- UniSTS:11633

D6S2270 (e-PCR)
- UniSTS:68477

D6S346E (e-PCR)
- UniSTS:153756

A002D34 (e-PCR)
- UniSTS:27554

JA06 (e-PCR)
- UniSTS:241076

RH45759 (e-PCR)
- UniSTS:63476

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
contributes_to G protein-coupled GABA receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled GABA receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled GABA receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	IEA Inferred from Electronic Annotation more info
enables G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in gamma-aminobutyric acid signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in gamma-aminobutyric acid signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in neuron-glial cell signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of postsynaptic membrane potential	IEA Inferred from Electronic Annotation more info
involved_in regulation of presynaptic membrane potential	IEA Inferred from Electronic Annotation more info
involved_in synaptic transmission, GABAergic	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of G protein-coupled GABA receptor complex	IPI Inferred from Physical Interaction more info	PubMed
part_of G protein-coupled receptor heterodimeric complex	IBA Inferred from Biological aspect of Ancestor more info
part_of G protein-coupled receptor heterodimeric complex	IPI Inferred from Physical Interaction more info	PubMed
located_in GABA-ergic synapse	IEA Inferred from Electronic Annotation more info
located_in Schaffer collateral - CA1 synapse	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
located_in presynaptic membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: gamma-aminobutyric acid type B receptor subunit 1

Names: GABA-B receptor, R1 subunit; gamma-aminobutyric acid (GABA) B receptor, 1; seven transmembrane helix receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029101.1 RefSeqGene

Range

5003..35948

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001319053.2 → NP_001305982.1 gamma-aminobutyric acid type B receptor subunit 1 isoform k

Status: REVIEWED

Description

Transcript Variant: This variant (5) uses an alternate splice site in the 5' region and initiates translation at a downstream start codon compared to variant 1. It encodes isoform k which has a shorter N-terminus than isoform a.

Source sequence(s)

AB208790, AJ225028, AL539611, AL645936

UniProtKB/TrEMBL

Q59HG8

Conserved Domains (3) summary

cd15291
Location:413 → 685

7tmC_GABA-B-R1; gamma-aminobutyric acid type B receptor subunit 1, member of the class C family of seven-transmembrane G protein-coupled receptors

pfam10211
Location:708 → 750

Ax_dynein_light; Axonemal dynein light chain

cd06366
Location:2 → 393

PBP1_GABAb_receptor; ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)
NM_001470.4 → NP_001461.1 gamma-aminobutyric acid type B receptor subunit 1 isoform a precursor

See identical proteins and their annotated locations for NP_001461.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

AB208790, AJ225028, AL539611, AL645936

Consensus CDS

CCDS4663.1

UniProtKB/Swiss-Prot

B0UXY7, O95375, O95468, O95975, O96022, Q5STL4, Q5SUJ8, Q5SUL3, Q71SG6, Q86W60, Q9UBS5, Q9UQQ0

UniProtKB/TrEMBL

A0A1U9X7Q3, A0A1U9X7Q8, A0A1U9X7Q9, A0A1U9X7R0, A0A1U9X7R1

Related

ENSP00000366233.4, ENST00000377034.9

Conserved Domains (4) summary

cd00033
Location:106 → 158

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

cd15291
Location:590 → 862

7tmC_GABA-B-R1; gamma-aminobutyric acid type B receptor subunit 1, member of the class C family of seven-transmembrane G protein-coupled receptors

pfam10211
Location:885 → 927

Ax_dynein_light; Axonemal dynein light chain

cd06366
Location:171 → 570

PBP1_GABAb_receptor; ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)
NM_021903.3 → NP_068703.1 gamma-aminobutyric acid type B receptor subunit 1 isoform b precursor

See identical proteins and their annotated locations for NP_068703.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks several exons in the 5' coding region, and initiates translation at an alternate start codon compared to variant 1. It encodes isoform b which has a distinct N-terminus and is shorter than isoform a.

Source sequence(s)

AJ225028, BC041332, BC042598, DA112662

Consensus CDS

CCDS4665.1

UniProtKB/TrEMBL

Q53EM0, Q5SUJ9, Q8IW08

Related

ENSP00000366211.4, ENST00000377012.9

Conserved Domains (5) summary

cd06366
Location:54 → 446

PBP1_GABAb_receptor; Ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)

pfam00003
Location:486 → 740

7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

pfam01094
Location:70 → 426

ANF_receptor; Receptor family ligand binding region

pfam10211
Location:768 → 810

Ax_dynein_light; Axonemal dynein light chain

pfam16643
Location:805 → 829

cNMPbd_u2; Unstructured region on cNMP-binding protein
NM_021904.4 → NP_068704.2 gamma-aminobutyric acid type B receptor subunit 1 isoform c precursor

See identical proteins and their annotated locations for NP_068704.2

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an in-frame exon in the 5' coding region compared to variant 1. It encodes isoform c which is shorter than isoform a.

Source sequence(s)

AB208790, AJ012187, AJ225028, AL539611, AL645936

Consensus CDS

CCDS4664.1

UniProtKB/TrEMBL

A0A140T9S4

Related

ENSP00000366215.4, ENST00000377016.8

Conserved Domains (3) summary

cd15291
Location:528 → 800

7tmC_GABA-B-R1; gamma-aminobutyric acid type B receptor subunit 1, member of the class C family of seven-transmembrane G protein-coupled receptors

pfam10211
Location:823 → 865

Ax_dynein_light; Axonemal dynein light chain

cd06366
Location:109 → 508

PBP1_GABAb_receptor; ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000006.12 Reference GRCh38.p14 Primary Assembly

Range

29602238..29633183 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005248982.3 → XP_005249039.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X1

See identical proteins and their annotated locations for XP_005249039.1

UniProtKB/TrEMBL

A0A1U9X7Q3, A0A1U9X7Q8, A0A1U9X7Q9, A0A1U9X7R1, C9J342

Related

ENSP00000417332.2, ENST00000476670.3

Conserved Domains (3) summary

cd15291
Location:595 → 867

7tmC_GABA-B-R1; gamma-aminobutyric acid type B receptor subunit 1, member of the class C family of seven-transmembrane G protein-coupled receptors

cd06366
Location:176 → 575

PBP1_GABAb_receptor; ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)

pfam00084
Location:112 → 162

Sushi; Sushi repeat (SCR repeat)
XM_006715047.5 → XP_006715110.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X2

See identical proteins and their annotated locations for XP_006715110.1

UniProtKB/TrEMBL

A0A140T9S4

Conserved Domains (3) summary

cd15291
Location:533 → 805

7tmC_GABA-B-R1; gamma-aminobutyric acid type B receptor subunit 1, member of the class C family of seven-transmembrane G protein-coupled receptors

pfam10211
Location:828 → 870

Ax_dynein_light; Axonemal dynein light chain

cd06366
Location:114 → 513

PBP1_GABAb_receptor; ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)
XM_011514453.4 → XP_011512755.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X3

See identical proteins and their annotated locations for XP_011512755.1

UniProtKB/TrEMBL

A0A140T9S4

Conserved Domains (5) summary

cd06366
Location:107 → 499

PBP1_GABAb_receptor; Ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)

pfam00003
Location:539 → 793

7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

pfam01094
Location:123 → 479

ANF_receptor; Receptor family ligand binding region

pfam10211
Location:821 → 863

Ax_dynein_light; Axonemal dynein light chain

pfam16643
Location:858 → 882

cNMPbd_u2; Unstructured region on cNMP-binding protein
XM_024446392.2 → XP_024302160.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X5

UniProtKB/TrEMBL

Q59HG8

Conserved Domains (3) summary

cd06366
Location:37 → 380

PBP1_GABAb_receptor; Ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)

pfam10211
Location:699 → 744

Ax_dynein_light; Axonemal dynein light chain

cd15291
Location:407 → 679

7tmC_GABA-B-R1; gamma-aminobutyric acid type B receptor subunit 1, member of the class C family of seven-transmembrane G protein-coupled receptors
XM_047418591.1 → XP_047274547.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X4
XM_011514455.2 → XP_011512757.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X6

See identical proteins and their annotated locations for XP_011512757.1

UniProtKB/TrEMBL

A0A140TA42

Conserved Domains (4) summary

cd06366
Location:176 → 568

PBP1_GABAb_receptor; Ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)

pfam00003
Location:608 → 677

7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

pfam00084
Location:112 → 162

Sushi; Sushi repeat (SCR repeat)

pfam01094
Location:192 → 548

ANF_receptor; Receptor family ligand binding region
XM_047418592.1 → XP_047274548.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X7
XM_047418593.1 → XP_047274549.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X8

Related

ENSP00000419061.1, ENST00000494877.5

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

NT_167244.2 Reference GRCh38.p14 ALT_REF_LOCI_1

Range

867963..898900 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054328454.1 → XP_054184429.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X1

UniProtKB/TrEMBL

C9J342
XM_054328456.1 → XP_054184431.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X3
XM_054328455.1 → XP_054184430.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X2
XM_054328458.1 → XP_054184433.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X5
XM_054328457.1 → XP_054184432.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X4
XM_054328459.1 → XP_054184434.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X6
XM_054328460.1 → XP_054184435.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X8

RNA

XR_008485589.1 RNA Sequence

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

NT_113891.3 Reference GRCh38.p14 ALT_REF_LOCI_2

Range

1088718..1119664 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054329751.1 → XP_054185726.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X1

UniProtKB/TrEMBL

C9J342
XM_054329752.1 → XP_054185727.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X2
XM_054329753.1 → XP_054185728.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X3
XM_054329755.1 → XP_054185730.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X5
XM_054329754.1 → XP_054185729.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X4
XM_054329756.1 → XP_054185731.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X6
XM_054329757.1 → XP_054185732.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X7
XM_054329758.1 → XP_054185733.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X8

Reference GRCh38.p14 ALT_REF_LOCI_3

Genomic

NT_167245.2 Reference GRCh38.p14 ALT_REF_LOCI_3

Range

867787..898733 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054330243.1 → XP_054186218.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X1

UniProtKB/TrEMBL

C9J342
XM_054330244.1 → XP_054186219.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X2
XM_054330245.1 → XP_054186220.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X3
XM_054330247.1 → XP_054186222.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X5
XM_054330246.1 → XP_054186221.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X4
XM_054330248.1 → XP_054186223.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X6
XM_054330249.1 → XP_054186224.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X7
XM_054330250.1 → XP_054186225.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X8

Reference GRCh38.p14 ALT_REF_LOCI_4

Genomic

NT_167246.2 Reference GRCh38.p14 ALT_REF_LOCI_4

Range

867419..898332 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054330538.1 → XP_054186513.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X10
XM_054330535.1 → XP_054186510.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X9

UniProtKB/TrEMBL

A0A0G2JKF9
XM_054330534.1 → XP_054186509.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X1
XM_054330537.1 → XP_054186512.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X3
XM_054330536.1 → XP_054186511.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X2
XM_054330540.1 → XP_054186515.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X5
XM_054330539.1 → XP_054186514.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X4
XM_054330541.1 → XP_054186516.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X6
XM_054330542.1 → XP_054186517.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X8

RNA

XR_008485698.1 RNA Sequence

Reference GRCh38.p14 ALT_REF_LOCI_5

Genomic

NT_167247.2 Reference GRCh38.p14 ALT_REF_LOCI_5

Range

867633..898576 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054330786.1 → XP_054186761.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X1

UniProtKB/TrEMBL

C9J342
XM_054330787.1 → XP_054186762.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X2
XM_054330788.1 → XP_054186763.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X3
XM_054330790.1 → XP_054186765.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X5
XM_054330789.1 → XP_054186764.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X4
XM_054330791.1 → XP_054186766.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X6
XM_054330792.1 → XP_054186767.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X7
XM_054330793.1 → XP_054186768.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X8

Reference GRCh38.p14 ALT_REF_LOCI_6

Genomic

NT_167248.2 Reference GRCh38.p14 ALT_REF_LOCI_6

Range

867750..898696 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054331023.1 → XP_054186998.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X1

UniProtKB/TrEMBL

C9J342
XM_054331024.1 → XP_054186999.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X2
XM_054331025.1 → XP_054187000.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X3
XM_054331027.1 → XP_054187002.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X5
XM_054331026.1 → XP_054187001.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X4
XM_054331028.1 → XP_054187003.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X6
XM_054331029.1 → XP_054187004.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X7
XM_054331030.1 → XP_054187005.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X8

Reference GRCh38.p14 ALT_REF_LOCI_7

Genomic

NT_167249.2 Reference GRCh38.p14 ALT_REF_LOCI_7

Range

941945..942223 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

NC_060930.1 Alternate T2T-CHM13v2.0

Range

29476949..29507887 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054355056.1 → XP_054211031.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X1

UniProtKB/TrEMBL

C9J342
XM_054355058.1 → XP_054211033.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X3
XM_054355057.1 → XP_054211032.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X2
XM_054355060.1 → XP_054211035.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X5
XM_054355059.1 → XP_054211034.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X4
XM_054355061.1 → XP_054211036.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X6
XM_054355062.1 → XP_054211037.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X7
XM_054355063.1 → XP_054211038.1 gamma-aminobutyric acid type B receptor subunit 1 isoform X8

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_021905.2: Suppressed sequence

Description

NM_021905.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.