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    DMRT3 doublesex and mab-3 related transcription factor 3 [ Homo sapiens (human) ]

    Gene ID: 58524, updated on 27-Nov-2024

    Summary

    Official Symbol
    DMRT3provided by HGNC
    Official Full Name
    doublesex and mab-3 related transcription factor 3provided by HGNC
    Primary source
    HGNC:HGNC:13909
    See related
    Ensembl:ENSG00000064218 MIM:614754; AllianceGenome:HGNC:13909
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DMRTA3
    Summary
    Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in male sex differentiation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including adult walking behavior; regulation of odontogenesis of dentin-containing tooth; and ventral spinal cord interneuron specification. Predicted to be located in chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in thyroid (RPKM 4.6), testis (RPKM 2.6) and 2 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See DMRT3 in Genome Data Viewer
    Location:
    9p24.3
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (976655..991732)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (977925..992996)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (976655..991732)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375949 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28120 Neighboring gene doublesex and mab-3 related transcription factor 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19726 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28121 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:969074-969636 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:970761-971321 Neighboring gene VISTA enhancer hs112 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:975821-976322 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:976323-976822 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:981223-981729 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19727 Neighboring gene RNA, U6 small nuclear 1073, pseudogene Neighboring gene H3 histone pseudogene 29

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC142144

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in adult walking behavior IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in male sex differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of odontogenesis of dentin-containing tooth IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sex differentiation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in transmission of nerve impulse IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ventral spinal cord interneuron specification IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    doublesex- and mab-3-related transcription factor 3
    Names
    DMRT-like family A3
    testis-specific protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021240.4NP_067063.1  doublesex- and mab-3-related transcription factor 3

      See identical proteins and their annotated locations for NP_067063.1

      Status: VALIDATED

      Source sequence(s)
      AF193873, AI052121, AL136365, BC113584
      Consensus CDS
      CCDS6443.1
      UniProtKB/Swiss-Prot
      Q7LA03, Q7LCH8, Q96SC7, Q9NQL9, Q9NRQ9
      Related
      ENSP00000190165.2, ENST00000190165.3
      Conserved Domains (2) summary
      cd14419
      Location:247289
      CUE_DMA_DMRTA3; CUE-like DMA domain found in doublesex- and mab-3-related transcription factor 3 (DMRTA3)
      pfam00751
      Location:2571
      DM; DM DNA binding domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      976655..991732
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      977925..992996
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)