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    NUMA1 nuclear mitotic apparatus protein 1 [ Homo sapiens (human) ]

    Gene ID: 4926, updated on 3-Dec-2024

    Summary

    Official Symbol
    NUMA1provided by HGNC
    Official Full Name
    nuclear mitotic apparatus protein 1provided by HGNC
    Primary source
    HGNC:HGNC:8059
    See related
    Ensembl:ENSG00000137497 MIM:164009; AllianceGenome:HGNC:8059
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NUMA; NMP-22
    Summary
    This gene encodes a large protein that forms a structural component of the nuclear matrix. The encoded protein interacts with microtubules and plays a role in the formation and organization of the mitotic spindle during cell division. Chromosomal translocation of this gene with the RARA (retinoic acid receptor, alpha) gene on chromosome 17 have been detected in patients with acute promyelocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
    Expression
    Ubiquitous expression in prostate (RPKM 51.4), ovary (RPKM 49.9) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See NUMA1 in Genome Data Viewer
    Location:
    11q13.4
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (72002864..72080542, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (71929780..72007446, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (71713910..71791588, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene XNDC1N-ZNF705EP-ALG1L9P readthrough Neighboring gene XRCC1 N-terminal domain containing 1, N-terminal like Neighboring gene olfactory receptor family 7 subfamily E member 126 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5171 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:71660091-71661028 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:71661029-71661964 Neighboring gene ring finger protein 121 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5172 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5173 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5174 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5175 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:71725991-71726738 Neighboring gene uncharacterized LOC100128494 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:71728895-71730094 Neighboring gene interleukin 18 binding protein Neighboring gene Sharpr-MPRA regulatory region 3523 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5176 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:71751839-71752624 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:71752625-71753408 Neighboring gene uncharacterized LOC124902815 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:71790999-71791954 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:71791955-71792909 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5180 Neighboring gene microRNA 3165 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5181 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3713 Neighboring gene leucine rich repeat containing 51 Neighboring gene leucine rich transmembrane and O-methyltransferase domain containing Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Interaction of HIV-1 Tat with NUMA1 in T-cells is identified by a proteomic strategy based on affinity chromatography PubMed
    retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human nuclear mitotic apparatus protein 1 (NUMA1) at amino acid residues 2054-2055 by the HIV-1 protease PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables disordered domain specific binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables dynein complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables microtubule minus-end binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables microtubule plus-end binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphatidylinositol binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables structural molecule activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables tubulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in anastral spindle assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in astral microtubule organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in astral microtubule organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in establishment of mitotic spindle orientation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in establishment of mitotic spindle orientation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in establishment of mitotic spindle orientation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in establishment of mitotic spindle orientation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in microtubule bundle formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in nucleus organization TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of BMP signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of chromosome separation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of hair follicle development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of intracellular transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of keratinocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of microtubule polymerization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of mitotic spindle elongation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein localization to cell cortex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein localization to spindle pole body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of spindle assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of metaphase plate congression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of mitotic spindle organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of mitotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell cortex region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cortical microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic microtubule bundle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in lateral cell cortex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in lateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microtubule bundle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in microtubule minus-end IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in microtubule plus-end IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitotic spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitotic spindle astral microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitotic spindle midzone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitotic spindle pole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitotic spindle pole IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in spindle TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in spindle microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in spindle microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in spindle pole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in spindle pole centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    nuclear mitotic apparatus protein 1
    Names
    SP-H antigen
    centrophilin stabilizes mitotic spindle in mitotic cells
    nuclear matrix protein-22
    structural nuclear protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286561.2NP_001273490.1  nuclear mitotic apparatus protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001273490.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AB210007, BC004165, BG754891, BG771637, Z11583, Z11584
      Consensus CDS
      CCDS66156.1
      UniProtKB/TrEMBL
      Q4LE64
      Related
      ENSP00000351851.6, ENST00000358965.10
      Conserved Domains (2) summary
      TIGR02168
      Location:10151717
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam01576
      Location:2541329
      Myosin_tail_1; Myosin tail
    2. NM_006185.4NP_006176.2  nuclear mitotic apparatus protein 1 isoform 1

      See identical proteins and their annotated locations for NP_006176.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AB210007, BC004165, BC027493, BG754891, BG771637
      Consensus CDS
      CCDS31633.1
      UniProtKB/Swiss-Prot
      H0YH75, Q14980, Q14981, Q9BTE9
      UniProtKB/TrEMBL
      Q4LE64
      Related
      ENSP00000377298.4, ENST00000393695.8
      Conserved Domains (2) summary
      cl25732
      Location:5631331
      SMC_N; RecF/RecN/SMC N terminal domain
      cl28033
      Location:17462016
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

    RNA

    1. NR_104476.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' terminal exon and lacks two alternate internal exons, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the reading frame found in variant 1.
      Source sequence(s)
      AP002490, BC004165, BC103765, BG754891
      Related
      ENST00000351960.10

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      72002864..72080542 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047427023.1XP_047282979.1  nuclear mitotic apparatus protein 1 isoform X4

      UniProtKB/TrEMBL
      Q4LE64
    2. XM_047427003.1XP_047282959.1  nuclear mitotic apparatus protein 1 isoform X2

      UniProtKB/TrEMBL
      Q4LE64
    3. XM_047427016.1XP_047282972.1  nuclear mitotic apparatus protein 1 isoform X3

      UniProtKB/Swiss-Prot
      H0YH75, Q14980, Q14981, Q9BTE9
      UniProtKB/TrEMBL
      Q4LE64
    4. XM_047426995.1XP_047282951.1  nuclear mitotic apparatus protein 1 isoform X1

      UniProtKB/TrEMBL
      Q4LE64
    5. XM_017017830.2XP_016873319.1  nuclear mitotic apparatus protein 1 isoform X4

      UniProtKB/TrEMBL
      Q4LE64
      Conserved Domains (2) summary
      TIGR02168
      Location:10151717
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam01576
      Location:2541329
      Myosin_tail_1; Myosin tail
    6. XM_047426997.1XP_047282953.1  nuclear mitotic apparatus protein 1 isoform X2

      UniProtKB/TrEMBL
      Q4LE64
    7. XM_011545055.2XP_011543357.1  nuclear mitotic apparatus protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011543357.1

      UniProtKB/TrEMBL
      Q4LE64
      Conserved Domains (2) summary
      cl25732
      Location:215911
      SMC_N; RecF/RecN/SMC N terminal domain
      cl28033
      Location:17642034
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
    8. XM_047427019.1XP_047282975.1  nuclear mitotic apparatus protein 1 isoform X4

      UniProtKB/TrEMBL
      Q4LE64
    9. XM_047426999.1XP_047282955.1  nuclear mitotic apparatus protein 1 isoform X2

      UniProtKB/TrEMBL
      Q4LE64
    10. XM_047427008.1XP_047282964.1  nuclear mitotic apparatus protein 1 isoform X3

      UniProtKB/Swiss-Prot
      H0YH75, Q14980, Q14981, Q9BTE9
      UniProtKB/TrEMBL
      Q4LE64
    11. XM_011545057.3XP_011543359.1  nuclear mitotic apparatus protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011543359.1

      UniProtKB/TrEMBL
      Q4LE64
      Conserved Domains (2) summary
      cl25732
      Location:215911
      SMC_N; RecF/RecN/SMC N terminal domain
      cl28033
      Location:17642034
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
    12. XM_047427026.1XP_047282982.1  nuclear mitotic apparatus protein 1 isoform X4

      UniProtKB/TrEMBL
      Q4LE64
    13. XM_047427004.1XP_047282960.1  nuclear mitotic apparatus protein 1 isoform X2

      UniProtKB/TrEMBL
      Q4LE64
    14. XM_047427010.1XP_047282966.1  nuclear mitotic apparatus protein 1 isoform X3

      UniProtKB/Swiss-Prot
      H0YH75, Q14980, Q14981, Q9BTE9
      UniProtKB/TrEMBL
      Q4LE64
    15. XM_011545056.3XP_011543358.1  nuclear mitotic apparatus protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011543358.1

      UniProtKB/TrEMBL
      Q4LE64
      Conserved Domains (2) summary
      cl25732
      Location:215911
      SMC_N; RecF/RecN/SMC N terminal domain
      cl28033
      Location:17642034
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
    16. XM_047427018.1XP_047282974.1  nuclear mitotic apparatus protein 1 isoform X4

      UniProtKB/TrEMBL
      Q4LE64
    17. XM_047426998.1XP_047282954.1  nuclear mitotic apparatus protein 1 isoform X2

      UniProtKB/TrEMBL
      Q4LE64
    18. XM_024448556.2XP_024304324.1  nuclear mitotic apparatus protein 1 isoform X3

      UniProtKB/Swiss-Prot
      H0YH75, Q14980, Q14981, Q9BTE9
      UniProtKB/TrEMBL
      Q4LE64
      Conserved Domains (2) summary
      cl25732
      Location:5631331
      SMC_N; RecF/RecN/SMC N terminal domain
      cl28033
      Location:17462016
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
    19. XM_024448555.2XP_024304323.1  nuclear mitotic apparatus protein 1 isoform X1

      UniProtKB/TrEMBL
      Q4LE64
      Conserved Domains (2) summary
      cl25732
      Location:215911
      SMC_N; RecF/RecN/SMC N terminal domain
      cl28033
      Location:17642034
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
    20. XM_047427021.1XP_047282977.1  nuclear mitotic apparatus protein 1 isoform X4

      UniProtKB/TrEMBL
      Q4LE64
    21. XM_047427000.1XP_047282956.1  nuclear mitotic apparatus protein 1 isoform X2

      UniProtKB/TrEMBL
      Q4LE64
    22. XM_047427013.1XP_047282969.1  nuclear mitotic apparatus protein 1 isoform X3

      UniProtKB/Swiss-Prot
      H0YH75, Q14980, Q14981, Q9BTE9
      UniProtKB/TrEMBL
      Q4LE64
    23. XM_011545060.3XP_011543362.1  nuclear mitotic apparatus protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011543362.1

      UniProtKB/TrEMBL
      Q4LE64
      Conserved Domains (2) summary
      cl25732
      Location:215911
      SMC_N; RecF/RecN/SMC N terminal domain
      cl28033
      Location:17642034
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
    24. XM_047427022.1XP_047282978.1  nuclear mitotic apparatus protein 1 isoform X4

      UniProtKB/TrEMBL
      Q4LE64
    25. XM_047427005.1XP_047282961.1  nuclear mitotic apparatus protein 1 isoform X2

      UniProtKB/TrEMBL
      Q4LE64
    26. XM_047427012.1XP_047282968.1  nuclear mitotic apparatus protein 1 isoform X3

      UniProtKB/Swiss-Prot
      H0YH75, Q14980, Q14981, Q9BTE9
      UniProtKB/TrEMBL
      Q4LE64
    27. XM_011545059.3XP_011543361.1  nuclear mitotic apparatus protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011543361.1

      UniProtKB/TrEMBL
      Q4LE64
      Conserved Domains (2) summary
      cl25732
      Location:215911
      SMC_N; RecF/RecN/SMC N terminal domain
      cl28033
      Location:17642034
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
    28. XM_047427009.1XP_047282965.1  nuclear mitotic apparatus protein 1 isoform X3

      UniProtKB/Swiss-Prot
      H0YH75, Q14980, Q14981, Q9BTE9
      UniProtKB/TrEMBL
      Q4LE64
    29. XM_047426996.1XP_047282952.1  nuclear mitotic apparatus protein 1 isoform X1

      UniProtKB/TrEMBL
      Q4LE64
    30. XM_047427020.1XP_047282976.1  nuclear mitotic apparatus protein 1 isoform X4

      UniProtKB/TrEMBL
      Q4LE64
    31. XM_047427001.1XP_047282957.1  nuclear mitotic apparatus protein 1 isoform X2

      UniProtKB/TrEMBL
      Q4LE64
    32. XM_047427011.1XP_047282967.1  nuclear mitotic apparatus protein 1 isoform X3

      UniProtKB/Swiss-Prot
      H0YH75, Q14980, Q14981, Q9BTE9
      UniProtKB/TrEMBL
      Q4LE64
    33. XM_011545058.2XP_011543360.1  nuclear mitotic apparatus protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011543360.1

      UniProtKB/TrEMBL
      Q4LE64
      Conserved Domains (2) summary
      cl25732
      Location:215911
      SMC_N; RecF/RecN/SMC N terminal domain
      cl28033
      Location:17642034
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
    34. XM_017017831.2XP_016873320.1  nuclear mitotic apparatus protein 1 isoform X4

      UniProtKB/TrEMBL
      Q4LE64
      Conserved Domains (2) summary
      TIGR02168
      Location:10151717
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam01576
      Location:2541329
      Myosin_tail_1; Myosin tail
    35. XM_047427006.1XP_047282962.1  nuclear mitotic apparatus protein 1 isoform X2

      UniProtKB/TrEMBL
      Q4LE64
    36. XM_047427014.1XP_047282970.1  nuclear mitotic apparatus protein 1 isoform X3

      UniProtKB/Swiss-Prot
      H0YH75, Q14980, Q14981, Q9BTE9
      UniProtKB/TrEMBL
      Q4LE64
    37. XM_011545062.3XP_011543364.1  nuclear mitotic apparatus protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011543364.1

      UniProtKB/TrEMBL
      Q4LE64
      Conserved Domains (2) summary
      cl25732
      Location:215911
      SMC_N; RecF/RecN/SMC N terminal domain
      cl28033
      Location:17642034
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
    38. XM_011545066.3XP_011543368.1  nuclear mitotic apparatus protein 1 isoform X4

      See identical proteins and their annotated locations for XP_011543368.1

      UniProtKB/TrEMBL
      Q4LE64
      Conserved Domains (2) summary
      TIGR02168
      Location:10151717
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam01576
      Location:2541329
      Myosin_tail_1; Myosin tail
    39. XM_011545065.3XP_011543367.1  nuclear mitotic apparatus protein 1 isoform X2

      UniProtKB/TrEMBL
      Q4LE64
      Conserved Domains (2) summary
      TIGR02168
      Location:10151717
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam01576
      Location:2541329
      Myosin_tail_1; Myosin tail
    40. XM_006718564.3XP_006718627.1  nuclear mitotic apparatus protein 1 isoform X3

      See identical proteins and their annotated locations for XP_006718627.1

      UniProtKB/Swiss-Prot
      H0YH75, Q14980, Q14981, Q9BTE9
      UniProtKB/TrEMBL
      Q4LE64
      Conserved Domains (2) summary
      cl25732
      Location:5631331
      SMC_N; RecF/RecN/SMC N terminal domain
      cl28033
      Location:17462016
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
    41. XM_011545054.3XP_011543356.1  nuclear mitotic apparatus protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011543356.1

      UniProtKB/TrEMBL
      Q4LE64
      Conserved Domains (2) summary
      cl25732
      Location:215911
      SMC_N; RecF/RecN/SMC N terminal domain
      cl28033
      Location:17642034
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
    42. XM_047427025.1XP_047282981.1  nuclear mitotic apparatus protein 1 isoform X4

      UniProtKB/TrEMBL
      Q4LE64
    43. XM_047427017.1XP_047282973.1  nuclear mitotic apparatus protein 1 isoform X3

      UniProtKB/Swiss-Prot
      H0YH75, Q14980, Q14981, Q9BTE9
      UniProtKB/TrEMBL
      Q4LE64
    44. XM_011545064.2XP_011543366.1  nuclear mitotic apparatus protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011543366.1

      UniProtKB/TrEMBL
      Q4LE64
      Conserved Domains (2) summary
      cl25732
      Location:215911
      SMC_N; RecF/RecN/SMC N terminal domain
      cl28033
      Location:17642034
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region
    45. XM_047427002.1XP_047282958.1  nuclear mitotic apparatus protein 1 isoform X2

      UniProtKB/TrEMBL
      Q4LE64
    46. XM_047427024.1XP_047282980.1  nuclear mitotic apparatus protein 1 isoform X4

      UniProtKB/TrEMBL
      Q4LE64
      Related
      ENSP00000478624.1, ENST00000620566.4
    47. XM_047427007.1XP_047282963.1  nuclear mitotic apparatus protein 1 isoform X2

      UniProtKB/TrEMBL
      Q4LE64
    48. XM_047427015.1XP_047282971.1  nuclear mitotic apparatus protein 1 isoform X3

      UniProtKB/Swiss-Prot
      H0YH75, Q14980, Q14981, Q9BTE9
      UniProtKB/TrEMBL
      Q4LE64
    49. XM_011545063.3XP_011543365.1  nuclear mitotic apparatus protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011543365.1

      UniProtKB/TrEMBL
      Q4LE64
      Conserved Domains (2) summary
      cl25732
      Location:215911
      SMC_N; RecF/RecN/SMC N terminal domain
      cl28033
      Location:17642034
      Herpes_ICP4_C; Herpesvirus ICP4-like protein C-terminal region

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      71929780..72007446 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054368967.1XP_054224942.1  nuclear mitotic apparatus protein 1 isoform X4

      UniProtKB/TrEMBL
      Q4LE64
    2. XM_054368943.1XP_054224918.1  nuclear mitotic apparatus protein 1 isoform X2

      UniProtKB/TrEMBL
      Q4LE64
    3. XM_054368958.1XP_054224933.1  nuclear mitotic apparatus protein 1 isoform X3

      UniProtKB/Swiss-Prot
      H0YH75, Q14980, Q14981, Q9BTE9
      UniProtKB/TrEMBL
      Q4LE64
    4. XM_054368931.1XP_054224906.1  nuclear mitotic apparatus protein 1 isoform X1

      UniProtKB/TrEMBL
      Q4LE64
    5. XM_054368960.1XP_054224935.1  nuclear mitotic apparatus protein 1 isoform X4

      UniProtKB/TrEMBL
      Q4LE64
    6. XM_054368937.1XP_054224912.1  nuclear mitotic apparatus protein 1 isoform X2

      UniProtKB/TrEMBL
      Q4LE64
    7. XM_054368924.1XP_054224899.1  nuclear mitotic apparatus protein 1 isoform X1

      UniProtKB/TrEMBL
      Q4LE64
    8. XM_054368963.1XP_054224938.1  nuclear mitotic apparatus protein 1 isoform X4

      UniProtKB/TrEMBL
      Q4LE64
    9. XM_054368939.1XP_054224914.1  nuclear mitotic apparatus protein 1 isoform X2

      UniProtKB/TrEMBL
      Q4LE64
    10. XM_054368950.1XP_054224925.1  nuclear mitotic apparatus protein 1 isoform X3

      UniProtKB/Swiss-Prot
      H0YH75, Q14980, Q14981, Q9BTE9
      UniProtKB/TrEMBL
      Q4LE64
    11. XM_054368926.1XP_054224901.1  nuclear mitotic apparatus protein 1 isoform X1

      UniProtKB/TrEMBL
      Q4LE64
    12. XM_054368971.1XP_054224946.1  nuclear mitotic apparatus protein 1 isoform X4

      UniProtKB/TrEMBL
      Q4LE64
    13. XM_054368944.1XP_054224919.1  nuclear mitotic apparatus protein 1 isoform X2

      UniProtKB/TrEMBL
      Q4LE64
    14. XM_054368952.1XP_054224927.1  nuclear mitotic apparatus protein 1 isoform X3

      UniProtKB/Swiss-Prot
      H0YH75, Q14980, Q14981, Q9BTE9
      UniProtKB/TrEMBL
      Q4LE64
    15. XM_054368928.1XP_054224903.1  nuclear mitotic apparatus protein 1 isoform X1

      UniProtKB/TrEMBL
      Q4LE64
    16. XM_054368932.1XP_054224907.1  nuclear mitotic apparatus protein 1 isoform X1

      UniProtKB/TrEMBL
      Q4LE64
    17. XM_054368962.1XP_054224937.1  nuclear mitotic apparatus protein 1 isoform X4

      UniProtKB/TrEMBL
      Q4LE64
    18. XM_054368949.1XP_054224924.1  nuclear mitotic apparatus protein 1 isoform X3

      UniProtKB/Swiss-Prot
      H0YH75, Q14980, Q14981, Q9BTE9
      UniProtKB/TrEMBL
      Q4LE64
    19. XM_054368938.1XP_054224913.1  nuclear mitotic apparatus protein 1 isoform X2

      UniProtKB/TrEMBL
      Q4LE64
    20. XM_054368925.1XP_054224900.1  nuclear mitotic apparatus protein 1 isoform X1

      UniProtKB/TrEMBL
      Q4LE64
    21. XM_054368965.1XP_054224940.1  nuclear mitotic apparatus protein 1 isoform X4

      UniProtKB/TrEMBL
      Q4LE64
    22. XM_054368940.1XP_054224915.1  nuclear mitotic apparatus protein 1 isoform X2

      UniProtKB/TrEMBL
      Q4LE64
    23. XM_054368955.1XP_054224930.1  nuclear mitotic apparatus protein 1 isoform X3

      UniProtKB/Swiss-Prot
      H0YH75, Q14980, Q14981, Q9BTE9
      UniProtKB/TrEMBL
      Q4LE64
    24. XM_054368927.1XP_054224902.1  nuclear mitotic apparatus protein 1 isoform X1

      UniProtKB/TrEMBL
      Q4LE64
    25. XM_054368966.1XP_054224941.1  nuclear mitotic apparatus protein 1 isoform X4

      UniProtKB/TrEMBL
      Q4LE64
    26. XM_054368945.1XP_054224920.1  nuclear mitotic apparatus protein 1 isoform X2

      UniProtKB/TrEMBL
      Q4LE64
    27. XM_054368954.1XP_054224929.1  nuclear mitotic apparatus protein 1 isoform X3

      UniProtKB/Swiss-Prot
      H0YH75, Q14980, Q14981, Q9BTE9
      UniProtKB/TrEMBL
      Q4LE64
    28. XM_054368933.1XP_054224908.1  nuclear mitotic apparatus protein 1 isoform X1

      UniProtKB/TrEMBL
      Q4LE64
    29. XM_054368951.1XP_054224926.1  nuclear mitotic apparatus protein 1 isoform X3

      UniProtKB/Swiss-Prot
      H0YH75, Q14980, Q14981, Q9BTE9
      UniProtKB/TrEMBL
      Q4LE64
    30. XM_054368964.1XP_054224939.1  nuclear mitotic apparatus protein 1 isoform X4

      UniProtKB/TrEMBL
      Q4LE64
    31. XM_054368941.1XP_054224916.1  nuclear mitotic apparatus protein 1 isoform X2

      UniProtKB/TrEMBL
      Q4LE64
    32. XM_054368953.1XP_054224928.1  nuclear mitotic apparatus protein 1 isoform X3

      UniProtKB/Swiss-Prot
      H0YH75, Q14980, Q14981, Q9BTE9
      UniProtKB/TrEMBL
      Q4LE64
    33. XM_054368929.1XP_054224904.1  nuclear mitotic apparatus protein 1 isoform X1

      UniProtKB/TrEMBL
      Q4LE64
    34. XM_054368968.1XP_054224943.1  nuclear mitotic apparatus protein 1 isoform X4

      UniProtKB/TrEMBL
      Q4LE64
    35. XM_054368946.1XP_054224921.1  nuclear mitotic apparatus protein 1 isoform X2

      UniProtKB/TrEMBL
      Q4LE64
    36. XM_054368956.1XP_054224931.1  nuclear mitotic apparatus protein 1 isoform X3

      UniProtKB/Swiss-Prot
      H0YH75, Q14980, Q14981, Q9BTE9
      UniProtKB/TrEMBL
      Q4LE64
    37. XM_054368934.1XP_054224909.1  nuclear mitotic apparatus protein 1 isoform X1

      UniProtKB/TrEMBL
      Q4LE64
    38. XM_054368961.1XP_054224936.1  nuclear mitotic apparatus protein 1 isoform X4

      UniProtKB/TrEMBL
      Q4LE64
    39. XM_054368936.1XP_054224911.1  nuclear mitotic apparatus protein 1 isoform X2

      UniProtKB/TrEMBL
      Q4LE64
    40. XM_054368948.1XP_054224923.1  nuclear mitotic apparatus protein 1 isoform X3

      UniProtKB/Swiss-Prot
      H0YH75, Q14980, Q14981, Q9BTE9
      UniProtKB/TrEMBL
      Q4LE64
    41. XM_054368923.1XP_054224898.1  nuclear mitotic apparatus protein 1 isoform X1

      UniProtKB/TrEMBL
      Q4LE64
    42. XM_054368970.1XP_054224945.1  nuclear mitotic apparatus protein 1 isoform X4

      UniProtKB/TrEMBL
      Q4LE64
    43. XM_054368959.1XP_054224934.1  nuclear mitotic apparatus protein 1 isoform X3

      UniProtKB/Swiss-Prot
      H0YH75, Q14980, Q14981, Q9BTE9
      UniProtKB/TrEMBL
      Q4LE64
    44. XM_054368942.1XP_054224917.1  nuclear mitotic apparatus protein 1 isoform X2

      UniProtKB/TrEMBL
      Q4LE64
    45. XM_054368935.1XP_054224910.1  nuclear mitotic apparatus protein 1 isoform X1

      UniProtKB/TrEMBL
      Q4LE64
    46. XM_054368957.1XP_054224932.1  nuclear mitotic apparatus protein 1 isoform X3

      UniProtKB/Swiss-Prot
      H0YH75, Q14980, Q14981, Q9BTE9
      UniProtKB/TrEMBL
      Q4LE64
    47. XM_054368969.1XP_054224944.1  nuclear mitotic apparatus protein 1 isoform X4

      UniProtKB/TrEMBL
      Q4LE64
    48. XM_054368947.1XP_054224922.1  nuclear mitotic apparatus protein 1 isoform X2

      UniProtKB/TrEMBL
      Q4LE64
    49. XM_054368930.1XP_054224905.1  nuclear mitotic apparatus protein 1 isoform X1

      UniProtKB/TrEMBL
      Q4LE64