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    TRIM15 tripartite motif containing 15 [ Homo sapiens (human) ]

    Gene ID: 89870, updated on 27-Nov-2024

    Summary

    Official Symbol
    TRIM15provided by HGNC
    Official Full Name
    tripartite motif containing 15provided by HGNC
    Primary source
    HGNC:HGNC:16284
    See related
    Ensembl:ENSG00000204610 AllianceGenome:HGNC:16284
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RNF93; ZNFB7; ZNF178
    Summary
    The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in duodenum (RPKM 12.6), small intestine (RPKM 9.2) and 6 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See TRIM15 in Genome Data Viewer
    Location:
    6p22.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (30163546..30172693)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (30027684..30036952)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (30131323..30140470)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA48 Neighboring gene tripartite motif containing 40 Neighboring gene tripartite motif containing 10 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:30139523-30140072 Neighboring gene MPRA-validated peak5749 silencer Neighboring gene PAIP1 pseudogene 1 Neighboring gene tripartite motif containing 26 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:30168993-30169678 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:30169679-30170363 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:30175183-30176130 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:30181514-30182402 Neighboring gene tripartite motif containing 26B, pseudogene Neighboring gene HLA complex group 17

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study of proneness to anger.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Fluorescence microscope analysis demonstrates a reduction of HIV-1 Gag fluorescence at the plasma membrane in cells containing cytoplasmic TRIM15 bodies PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables molecular sequestering activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase TRIM15
    Names
    RING finger protein 93
    tripartite motif-containing protein 15
    zinc finger protein 178
    zinc finger protein B7
    NP_150232.2
    XP_011513289.1
    XP_011513290.1
    XP_047275459.1
    XP_054184499.1
    XP_054184500.1
    XP_054184501.1
    XP_054185901.1
    XP_054185902.1
    XP_054185903.1
    XP_054186394.1
    XP_054186395.1
    XP_054186396.1
    XP_054186667.1
    XP_054186668.1
    XP_054186669.1
    XP_054186887.1
    XP_054186888.1
    XP_054186889.1
    XP_054187166.1
    XP_054187167.1
    XP_054187168.1
    XP_054187408.1
    XP_054187409.1
    XP_054187410.1
    XP_054212687.1
    XP_054212688.1
    XP_054212689.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_033229.3NP_150232.2  E3 ubiquitin-protein ligase TRIM15

      See identical proteins and their annotated locations for NP_150232.2

      Status: REVIEWED

      Source sequence(s)
      AI739162, AL669914, BC038585, BP270476, U34249
      Consensus CDS
      CCDS4677.1
      UniProtKB/Swiss-Prot
      A2BEC9, O95604, Q8IUX9, Q9C018, Q9C019
      UniProtKB/TrEMBL
      A0A0G2JJP1, A0A1U9X8P2, A6NEF7, A8K2L5, Q0EFD1, Q5SRL0
      Related
      ENSP00000365884.4, ENST00000376694.9
      Conserved Domains (5) summary
      smart00336
      Location:80119
      BBOX; B-Box-type zinc finger
      pfam09088
      Location:252327
      MIF4G_like; MIF4G like
      cd15826
      Location:295464
      SPRY_PRY_TRIM15; PRY/SPRY domain in tripartite motif-binding protein 15 (TRIM15)
      cd16543
      Location:1661
      RING-HC_RNF135_like; RING finger, HC subclass, found in RING finger protein 135 (RNF135), tripartite motif-containing protein 15 (TRIM15) and similar proteins
      cl25732
      Location:121241
      SMC_N; RecF/RecN/SMC N terminal domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      30163546..30172693
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011514987.2XP_011513289.1  E3 ubiquitin-protein ligase TRIM15 isoform X1

      Conserved Domains (2) summary
      pfam09088
      Location:147222
      MIF4G_like; MIF4G like
      cd15826
      Location:190359
      SPRY_PRY_TRIM15; PRY/SPRY domain in tripartite motif-binding protein 15 (TRIM15)
    2. XM_047419503.1XP_047275459.1  E3 ubiquitin-protein ligase TRIM15 isoform X3

    3. XM_011514988.3XP_011513290.1  E3 ubiquitin-protein ligase TRIM15 isoform X2

      See identical proteins and their annotated locations for XP_011513290.1

      Conserved Domains (2) summary
      pfam09088
      Location:45120
      MIF4G_like; MIF4G like
      cd15826
      Location:88257
      SPRY_PRY_TRIM15; PRY/SPRY domain in tripartite motif-binding protein 15 (TRIM15)

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_167244.2 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      1421505..1430773
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054328524.1XP_054184499.1  E3 ubiquitin-protein ligase TRIM15 isoform X1

    2. XM_054328526.1XP_054184501.1  E3 ubiquitin-protein ligase TRIM15 isoform X3

    3. XM_054328525.1XP_054184500.1  E3 ubiquitin-protein ligase TRIM15 isoform X2

    Reference GRCh38.p14 ALT_REF_LOCI_2

    Genomic

    1. NT_113891.3 Reference GRCh38.p14 ALT_REF_LOCI_2

      Range
      1643223..1652491
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054329926.1XP_054185901.1  E3 ubiquitin-protein ligase TRIM15 isoform X1

    2. XM_054329928.1XP_054185903.1  E3 ubiquitin-protein ligase TRIM15 isoform X3

    3. XM_054329927.1XP_054185902.1  E3 ubiquitin-protein ligase TRIM15 isoform X2

    Reference GRCh38.p14 ALT_REF_LOCI_3

    Genomic

    1. NT_167245.2 Reference GRCh38.p14 ALT_REF_LOCI_3

      Range
      1419326..1428594
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054330419.1XP_054186394.1  E3 ubiquitin-protein ligase TRIM15 isoform X1

    2. XM_054330421.1XP_054186396.1  E3 ubiquitin-protein ligase TRIM15 isoform X3

    3. XM_054330420.1XP_054186395.1  E3 ubiquitin-protein ligase TRIM15 isoform X2

    Reference GRCh38.p14 ALT_REF_LOCI_4

    Genomic

    1. NT_167246.2 Reference GRCh38.p14 ALT_REF_LOCI_4

      Range
      1474127..1483395
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054330692.1XP_054186667.1  E3 ubiquitin-protein ligase TRIM15 isoform X1

    2. XM_054330694.1XP_054186669.1  E3 ubiquitin-protein ligase TRIM15 isoform X3

    3. XM_054330693.1XP_054186668.1  E3 ubiquitin-protein ligase TRIM15 isoform X2

    Reference GRCh38.p14 ALT_REF_LOCI_5

    Genomic

    1. NT_167247.2 Reference GRCh38.p14 ALT_REF_LOCI_5

      Range
      1507498..1516766
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054330912.1XP_054186887.1  E3 ubiquitin-protein ligase TRIM15 isoform X1

    2. XM_054330914.1XP_054186889.1  E3 ubiquitin-protein ligase TRIM15 isoform X3

    3. XM_054330913.1XP_054186888.1  E3 ubiquitin-protein ligase TRIM15 isoform X2

    Reference GRCh38.p14 ALT_REF_LOCI_6

    Genomic

    1. NT_167248.2 Reference GRCh38.p14 ALT_REF_LOCI_6

      Range
      1418553..1427821
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054331191.1XP_054187166.1  E3 ubiquitin-protein ligase TRIM15 isoform X1

    2. XM_054331193.1XP_054187168.1  E3 ubiquitin-protein ligase TRIM15 isoform X3

    3. XM_054331192.1XP_054187167.1  E3 ubiquitin-protein ligase TRIM15 isoform X2

    Reference GRCh38.p14 ALT_REF_LOCI_7

    Genomic

    1. NT_167249.2 Reference GRCh38.p14 ALT_REF_LOCI_7

      Range
      1462356..1471624
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054331433.1XP_054187408.1  E3 ubiquitin-protein ligase TRIM15 isoform X1

    2. XM_054331435.1XP_054187410.1  E3 ubiquitin-protein ligase TRIM15 isoform X3

    3. XM_054331434.1XP_054187409.1  E3 ubiquitin-protein ligase TRIM15 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      30027684..30036952
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054356712.1XP_054212687.1  E3 ubiquitin-protein ligase TRIM15 isoform X1

    2. XM_054356714.1XP_054212689.1  E3 ubiquitin-protein ligase TRIM15 isoform X3

    3. XM_054356713.1XP_054212688.1  E3 ubiquitin-protein ligase TRIM15 isoform X2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_052812.1: Suppressed sequence

      Description
      NM_052812.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript.