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    CD24 CD24 molecule [ Homo sapiens (human) ]

    Gene ID: 100133941, updated on 9-Dec-2024

    Summary

    Official Symbol
    CD24provided by HGNC
    Official Full Name
    CD24 moleculeprovided by HGNC
    Primary source
    HGNC:HGNC:1645
    See related
    Ensembl:ENSG00000272398 MIM:600074; AllianceGenome:HGNC:1645
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD24A
    Summary
    This gene encodes a sialoglycoprotein that is expressed on mature granulocytes and B cells and modulates growth and differentiation signals to these cells. The precursor protein is cleaved to a short 32 amino acid mature peptide which is anchored via a glycosyl phosphatidylinositol (GPI) link to the cell surface. This gene was missing from previous genome assemblies, but is properly located on chromosome 6. Non-transcribed pseudogenes have been designated on chromosomes 1, 15, 20, and Y. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
    Expression
    Biased expression in thyroid (RPKM 586.8), esophagus (RPKM 431.3) and 12 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CD24 in Genome Data Viewer
    Location:
    6q21
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (106969831..106976855, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (108145896..108152920, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 (PATCHES) NW_004504300.1 (274454..281478, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 12 Neighboring gene trafficking protein particle complex subunit 6A-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17434 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17435 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:107312640-107312741 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17436 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24899 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24898 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:107361561-107362452 Neighboring gene mitochondrial transcription rescue factor 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:107382561-107383456 Neighboring gene BEN domain containing 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:107414410-107414593 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:107426683-107427338 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17437 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17438 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17439

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ22950, FLJ43543, MGC75043

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein tyrosine kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein tyrosine kinase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in B cell receptor transport into membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in T cell costimulation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in Wnt signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in cell activation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in cell-cell adhesion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in chemokine receptor transport out of membrane raft ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cholesterol homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in glomerular parietal epithelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in immune response-regulating cell surface receptor signaling pathway IC
    Inferred by Curator
    more info
    PubMed 
    involved_in intrinsic apoptotic signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of transforming growth factor beta3 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in podocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of MAP kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of activated T cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of nephron tubule epithelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of MAPK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of cytokine-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in regulation of epithelial cell differentiation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in respiratory burst IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to estrogen IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to molecule of bacterial origin ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in membrane raft IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    signal transducer CD24
    Names
    CD24 antigen (small cell lung carcinoma cluster 4 antigen)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_041768.1 RefSeqGene

      Range
      7127..12025
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001291737.1NP_001278666.1  signal transducer CD24 isoform a preproprotein

      See identical proteins and their annotated locations for NP_001278666.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3 and 7 encode isoform a.
      Source sequence(s)
      AK026603, AK125531, AU125939, BU580553, DA753855
      Consensus CDS
      CCDS75499.1
      UniProtKB/Swiss-Prot
      A0A087WYI6, B6EC88, P25063, Q16257, Q53XS0, R4I4T5
      Related
      ENSP00000483838.1, ENST00000610952.1
      Conserved Domains (1) summary
      pfam14984
      Location:4779
      CD24; CD24 protein
    2. NM_001291738.1NP_001278667.1  signal transducer CD24 isoform a preproprotein

      See identical proteins and their annotated locations for NP_001278667.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3 and 7 encode isoform a.
      Source sequence(s)
      AK026603, AK125531, BU580553, DA378105
      Consensus CDS
      CCDS75499.1
      UniProtKB/Swiss-Prot
      A0A087WYI6, B6EC88, P25063, Q16257, Q53XS0, R4I4T5
      Conserved Domains (1) summary
      pfam14984
      Location:4779
      CD24; CD24 protein
    3. NM_001291739.1NP_001278668.1  signal transducer CD24 isoform b

      See identical proteins and their annotated locations for NP_001278668.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is longer than isoform a.
      Source sequence(s)
      AK026603, AK125531, BU580553, DA518957
      Consensus CDS
      CCDS78166.1
      UniProtKB/TrEMBL
      A0A087WYI6
      Related
      ENSP00000481841.1, ENST00000622315.1
      Conserved Domains (1) summary
      pfam14984
      Location:96128
      CD24; CD24 protein
    4. NM_001359084.1NP_001346013.1  signal transducer CD24 isoform a preproprotein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3 and 7 encode isoform a.
      Source sequence(s)
      AK026603, DA521039, FP885534
      Consensus CDS
      CCDS75499.1
      UniProtKB/Swiss-Prot
      A0A087WYI6, B6EC88, P25063, Q16257, Q53XS0, R4I4T5
      Related
      ENSP00000475625.1, ENST00000606017.2
      Conserved Domains (1) summary
      pfam14984
      Location:4779
      CD24; CD24 protein
    5. NM_013230.3NP_037362.1  signal transducer CD24 isoform a preproprotein

      See identical proteins and their annotated locations for NP_037362.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3 and 7 encode isoform a.
      Source sequence(s)
      AK026603, AK125531, BG755979, BU580553
      Consensus CDS
      CCDS75499.1
      UniProtKB/Swiss-Prot
      A0A087WYI6, B6EC88, P25063, Q16257, Q53XS0, R4I4T5
      Related
      ENSP00000483985.1, ENST00000619133.4
      Conserved Domains (1) summary
      pfam14984
      Location:4779
      CD24; CD24 protein

    RNA

    1. NR_117089.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks the internal exon and contains an alternate 5' terminal exon, compared to variant 1. This variant is represented as non-coding because it lacks an in-frame ORF, compared to variant 1.
      Source sequence(s)
      AK026603, AK125531, AU125939, BU580553, DA745135
    2. NR_117090.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks the internal exon, compared to variant 1. This variant is represented as non-coding because it lacks an in-frame ORF, compared to variant 1.
      Source sequence(s)
      AK026603, AK125531, BG755979, BU580553, DA253943

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      106969831..106976855 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      108145896..108152920 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054353971.1XP_054209946.1  signal transducer CD24 isoform X1