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    ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 [ Homo sapiens (human) ]

    Gene ID: 954, updated on 9-Dec-2024

    Summary

    Official Symbol
    ENTPD2provided by HGNC
    Official Full Name
    ectonucleoside triphosphate diphosphohydrolase 2provided by HGNC
    Primary source
    HGNC:HGNC:3364
    See related
    Ensembl:ENSG00000054179 MIM:602012; AllianceGenome:HGNC:3364
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD39L1; NTPDase-2
    Summary
    The protein encoded by this gene is the type 2 enzyme of the ecto-nucleoside triphosphate diphosphohydrolase family (E-NTPDase). E-NTPDases are a family of ecto-nucleosidases that hydrolyze 5'-triphosphates. This ecto-ATPase is an integral membrane protein. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in duodenum (RPKM 4.7), prostate (RPKM 4.6) and 17 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ENTPD2 in Genome Data Viewer
    Location:
    9q34.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (137048107..137054061, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (149283232..149291667, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (139942559..139948513, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2908 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29338 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:139929142-139930030 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:139930031-139930917 Neighboring gene fucosyltransferase 7 Neighboring gene neural proliferation, differentiation and control 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:139940694-139941363 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:139943096-139943624 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:139943625-139944153 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20567 Neighboring gene uncharacterized LOC105376327 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20568 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20569 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:139958261-139959038 Neighboring gene suppressor APC domain containing 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:139962228-139963208 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20571 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20572 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20573 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:139965171-139966150 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:139968734-139969347 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20574 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20575 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20576 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20577 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:139972693-139973571 Neighboring gene UDP-N-acetylglucosamine pyrophosphorylase 1 like 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:139977971-139978205

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GDP phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables UDP phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ribonucleoside triphosphate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nucleoside diphosphate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in platelet activation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in purine ribonucleoside diphosphate catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in basement membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular exosome HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    ectonucleoside triphosphate diphosphohydrolase 2
    Names
    CD39 antigen-like 1
    NTPDase 2
    ecto-ATP diphosphohydrolase 2
    ecto-ATPDase 2
    ecto-ATPase 2
    NP_001237.1
    NP_982293.1
    XP_011517514.1
    XP_054220181.1
    XP_054220182.1
    XP_054220183.1
    XP_054220184.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029427.1 RefSeqGene

      Range
      4993..10947
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001246.4NP_001237.1  ectonucleoside triphosphate diphosphohydrolase 2 isoform 2

      See identical proteins and their annotated locations for NP_001237.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AF144748, AL807752, BC035738, CB045339, U91510
      Consensus CDS
      CCDS7025.1
      UniProtKB/Swiss-Prot
      Q9Y5L3
      Related
      ENSP00000312494.5, ENST00000312665.7
      Conserved Domains (1) summary
      cl17037
      Location:39430
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    2. NM_203468.3NP_982293.1  ectonucleoside triphosphate diphosphohydrolase 2 isoform 1

      See identical proteins and their annotated locations for NP_982293.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AF144748, AL807752, BC035738, CB045339
      Consensus CDS
      CCDS7026.1
      UniProtKB/Swiss-Prot
      O15464, Q5SPY6, Q5SPY7, Q9Y5L3
      Related
      ENSP00000347213.2, ENST00000355097.7
      Conserved Domains (1) summary
      cl17037
      Location:39453
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      137048107..137054061 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011519212.3XP_011517514.1  ectonucleoside triphosphate diphosphohydrolase 2 isoform X1

      Conserved Domains (1) summary
      cl17037
      Location:31350
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      149283232..149291667 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054364206.1XP_054220181.1  ectonucleoside triphosphate diphosphohydrolase 2 isoform X2

    2. XM_054364207.1XP_054220182.1  ectonucleoside triphosphate diphosphohydrolase 2 isoform X2

    3. XM_054364208.1XP_054220183.1  ectonucleoside triphosphate diphosphohydrolase 2 isoform X3

    4. XM_054364209.1XP_054220184.1  ectonucleoside triphosphate diphosphohydrolase 2 isoform X1