U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CCDC198 coiled-coil domain containing 198 [ Homo sapiens (human) ]

    Gene ID: 55195, updated on 3-Dec-2024

    Summary

    Official Symbol
    CCDC198provided by HGNC
    Official Full Name
    coiled-coil domain containing 198provided by HGNC
    Primary source
    HGNC:HGNC:20189
    See related
    Ensembl:ENSG00000100557 AllianceGenome:HGNC:20189
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FAME; C14orf105
    Summary
    Predicted to be involved in energy homeostasis. Predicted to be part of cytoplasmic vesicle and plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in kidney (RPKM 18.4), gall bladder (RPKM 5.9) and 2 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CCDC198 in Genome Data Viewer
    Location:
    14q22.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (57469300..57493857, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (51675743..51700299, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (57936018..57960575, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:57735423-57736006 Neighboring gene adaptor related protein complex 5 subunit mu 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:57810066-57810610 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:57831098-57831989 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr14:57849692-57850526 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:57857288-57858283 Neighboring gene N-alpha-acetyltransferase 30, NatC catalytic subunit Neighboring gene uncharacterized LOC105370519 Neighboring gene uncharacterized LOC105370518 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:58047958-58049157 Neighboring gene solute carrier family 35 member F4 Neighboring gene serine and arginine rich splicing factor 10 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ10650

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in energy homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    factor associated with metabolism and energy
    Names
    Factor Associated with Metabolism and Energy
    uncharacterized protein C14orf105

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_054635.1 RefSeqGene

      Range
      5124..29681
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001283056.2NP_001269985.1  factor associated with metabolism and energy isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK001512, AK223127, AL355834, BC143567, BX470593
      Consensus CDS
      CCDS61459.1
      UniProtKB/TrEMBL
      B7ZL43, F5GWJ3
      Related
      ENSP00000392368.2, ENST00000422976.6
      Conserved Domains (1) summary
      pfam15398
      Location:1336
      DUF4619; Domain of unknown function (DUF4619)
    2. NM_001283057.2NP_001269986.1  factor associated with metabolism and energy isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AK001512, AK223127, AL355834, BC117405, BX470593
      Consensus CDS
      CCDS61458.1
      UniProtKB/TrEMBL
      B7ZL43, E9PSE9
      Related
      ENSP00000434003.1, ENST00000534126.5
      Conserved Domains (1) summary
      pfam15398
      Location:1295
      DUF4619; Domain of unknown function (DUF4619)
    3. NM_001283058.2NP_001269987.1  factor associated with metabolism and energy isoform 4

      See identical proteins and their annotated locations for NP_001269987.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an exon and uses an alternate splice site in the coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (4) is shorter and has a distinct N-terminus, compared to isoform 1. Variants 4 and 5 encode the same isoform (4).
      Source sequence(s)
      AK001512, AK223127, AL355834, BC143565, BX470593
      UniProtKB/Swiss-Prot
      Q9NVL8
      Conserved Domains (1) summary
      pfam15398
      Location:15207
      DUF4619; Domain of unknown function (DUF4619)
    4. NM_001283059.2NP_001269988.1  factor associated with metabolism and energy isoform 4

      See identical proteins and their annotated locations for NP_001269988.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, lacks an exon and uses an alternate splice site in the coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (4) is shorter and has a distinct N-terminus, compared to isoform 1. Variants 4 and 5 encode the same isoform (4).
      Source sequence(s)
      AK001512, AK223127, AL355834, BC143568, BX470593
      UniProtKB/Swiss-Prot
      Q9NVL8
      Conserved Domains (1) summary
      pfam15398
      Location:15207
      DUF4619; Domain of unknown function (DUF4619)
    5. NM_001283060.2NP_001269989.1  factor associated with metabolism and energy isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) contains multiple differences in the UTRs and in the coding region, compared to variant 1. It initiates translation at an in-frame downstream start codon. The encoded isoform (5) has a shorter N-terminus and a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AI733133, AL355834, BC028060
      UniProtKB/TrEMBL
      Q05C89
      Conserved Domains (1) summary
      pfam15398
      Location:1140
      DUF4619; Domain of unknown function (DUF4619)
    6. NM_018168.4NP_060638.2  factor associated with metabolism and energy isoform 2

      See identical proteins and their annotated locations for NP_060638.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon and uses an alternate splice site in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AK001512, AK223127, AL355834, BX470593
      Consensus CDS
      CCDS9730.1
      UniProtKB/Swiss-Prot
      Q17R99, Q53G04, Q9NVL8
      UniProtKB/TrEMBL
      B7ZL43
      Related
      ENSP00000216445.3, ENST00000216445.8
      Conserved Domains (1) summary
      pfam15398
      Location:1296
      DUF4619; Domain of unknown function (DUF4619)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      57469300..57493857 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047431523.1XP_047287479.1  factor associated with metabolism and energy isoform X2

    2. XM_047431522.1XP_047287478.1  factor associated with metabolism and energy isoform X1

      UniProtKB/TrEMBL
      B7ZL43
    3. XM_005267811.4XP_005267868.1  factor associated with metabolism and energy isoform X9

      Conserved Domains (1) summary
      pfam15398
      Location:15208
      DUF4619; Domain of unknown function (DUF4619)
    4. XM_047431524.1XP_047287480.1  factor associated with metabolism and energy isoform X3

    5. XM_047431529.1XP_047287485.1  factor associated with metabolism and energy isoform X8

    6. XM_047431526.1XP_047287482.1  factor associated with metabolism and energy isoform X5

    7. XM_047431528.1XP_047287484.1  factor associated with metabolism and energy isoform X7

    8. XM_047431525.1XP_047287481.1  factor associated with metabolism and energy isoform X4

    9. XM_047431527.1XP_047287483.1  factor associated with metabolism and energy isoform X6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      51675743..51700299 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054376295.1XP_054232270.1  factor associated with metabolism and energy isoform X2

    2. XM_054376294.1XP_054232269.1  factor associated with metabolism and energy isoform X1

      UniProtKB/TrEMBL
      B7ZL43
    3. XM_054376296.1XP_054232271.1  factor associated with metabolism and energy isoform X3

    4. XM_054376301.1XP_054232276.1  factor associated with metabolism and energy isoform X8

    5. XM_054376298.1XP_054232273.1  factor associated with metabolism and energy isoform X5

    6. XM_054376300.1XP_054232275.1  factor associated with metabolism and energy isoform X7

    7. XM_054376297.1XP_054232272.1  factor associated with metabolism and energy isoform X4

    8. XM_054376299.1XP_054232274.1  factor associated with metabolism and energy isoform X6