U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    COPS9 COP9 signalosome subunit 9 [ Homo sapiens (human) ]

    Gene ID: 150678, updated on 27-Nov-2024

    Summary

    Official Symbol
    COPS9provided by HGNC
    Official Full Name
    COP9 signalosome subunit 9provided by HGNC
    Primary source
    HGNC:HGNC:21314
    See related
    Ensembl:ENSG00000172428 MIM:619349; AllianceGenome:HGNC:21314
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CSNAP; MYEOV2
    Summary
    Involved in several processes, including cellular response to UV; cytoplasmic sequestering of protein; and negative regulation of protein neddylation. Located in chromatin; cytoplasm; and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in brain (RPKM 12.9), fat (RPKM 12.7) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See COPS9 in Genome Data Viewer
    Location:
    2q37.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (240126548..240136347, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (240619322..240629121, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (241065980..241075764, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 9 subfamily S member 24 pseudogene Neighboring gene olfactory receptor family 5 subfamily S member 1 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12506 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17394 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17395 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241078745-241079469 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241079470-241080193 Neighboring gene otospiralin Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241094499-241094998 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:241107126-241107741 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:241137725-241137897 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241139753-241140254 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr2:241144761-241145650 Neighboring gene uncharacterized LOC107985836

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    COP9 signalosome complex subunit 9
    Names
    CSN acidic protein
    helicase/primase complex protein
    myeloma overexpressed 2
    myeloma-overexpressed gene 2 protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163424.2NP_001156896.1  COP9 signalosome complex subunit 9 isoform 2

      See identical proteins and their annotated locations for NP_001156896.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region and an alternate splice pattern in the 3' coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment near the N-terminus and has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC013469, AF487338, CN304277
      Consensus CDS
      CCDS63183.1
      UniProtKB/Swiss-Prot
      Q8N110, Q8WXC6
      Related
      ENSP00000475979.1, ENST00000607357.2
      Conserved Domains (1) summary
      pfam15004
      Location:150
      MYEOV2; Myeloma-overexpressed-like
    2. NM_138336.1NP_612209.1  COP9 signalosome complex subunit 9 isoform 1

      See identical proteins and their annotated locations for NP_612209.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AF453951
      Consensus CDS
      CCDS2532.1
      UniProtKB/Swiss-Prot
      Q8WXC6
      Related
      ENSP00000304147.3, ENST00000307266.7
      Conserved Domains (1) summary
      pfam15004
      Location:2576
      MYEOV2; Myeloma-overexpressed-like

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      240126548..240136347 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017003411.2XP_016858900.2  COP9 signalosome complex subunit 9 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      240619322..240629121 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054340658.1XP_054196633.1  COP9 signalosome complex subunit 9 isoform X1