Adprh ADP-ribosylarginine hydrolase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adprhprovided by MGI
Official Full Name: ADP-ribosylarginine hydrolaseprovided by MGI
Primary source: MGI:MGI:1098234
See related: Ensembl:ENSMUSG00000002844 AllianceGenome:MGI:1098234
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Arh1
Summary: Enables ADP-ribosylarginine hydrolase activity. Involved in protein modification process. Predicted to be located in extracellular space. Is expressed in cerebral cortex. Orthologous to human ADPRH (ADP-ribosylarginine hydrolase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in ovary adult (RPKM 55.7), adrenal adult (RPKM 52.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 B3- B4; 16 26.86 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (38265761..38273051, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (38445399..38452689, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Intestinal loops derived from female ADP-ribosylarginine hydrolase knockout (ARH1-KO) mice when injected with cholera toxin showed increased fluid accumulation compared to male ARH1-KO mice.
Title: Enhanced sensitivity to cholera toxin in female ADP-ribosylarginine hydrolase (ARH1)-deficient mice.
ARH1(-/-) and ARH1(+/-) mice spontaneously develop lymphomas, adenocarcinomas, & metastases more frequently than wild-type. Proper control of protein ADP-ribosylation levels affected by ARH1 is essential for cancer suppression.
Title: ADP-ribosylarginine hydrolase regulates cell proliferation and tumorigenesis.
ADP-ribosylarginine hydrolase promoter activity pattern and involvement of Sp transcription factors are consistent with prior observations of widespread hydrolase expression in mammalian tissues.
Title: Genomic organization and promoter analysis of the mouse ADP-ribosylarginine hydrolase gene.
Cholera toxin-catalyzed ADP-ribosylation of cell proteins can be counteracted by ADPRH, which could function as a modifier gene in disease.
Title: Enhanced sensitivity to cholera toxin in ADP-ribosylarginine hydrolase-deficient mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

NoName (e-PCR)
- UniSTS:237512

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ADP-ribosylarginine hydrolase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ADP-ribosylarginine hydrolase activity	ISO Inferred from Sequence Orthology more info
enables ADP-ribosylarginine hydrolase activity	ISS Inferred from Sequence or Structural Similarity more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables potassium ion binding	ISO Inferred from Sequence Orthology more info
enables potassium ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in protein de-ADP-ribosylation	ISO Inferred from Sequence Orthology more info
involved_in protein de-ADP-ribosylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein modification process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein modification process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ADP-ribosylarginine hydrolase

Names: ADP-ribose-L-arginine cleaving enzyme; [Protein ADP-ribosylarginine] hydrolase

NP_031440.1

EC 3.2.2.19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.