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    Pip5kl1 phosphatidylinositol-4-phosphate 5-kinase-like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 687758, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Pip5kl1provided by RGD
    Official Full Name
    phosphatidylinositol-4-phosphate 5-kinase-like 1provided by RGD
    Primary source
    RGD:1597527
    See related
    EnsemblRapid:ENSRNOG00000048676 AllianceGenome:RGD:1597527
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable 1-phosphatidylinositol-4-phosphate 5-kinase activity. Predicted to be involved in several processes, including negative regulation of mitochondrial membrane potential; negative regulation of protein phosphorylation; and phosphatidylinositol phosphate biosynthetic process. Predicted to be located in cell projection and cytosol. Predicted to be active in plasma membrane. Orthologous to human PIP5KL1 (phosphatidylinositol-4-phosphate 5-kinase like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 24.5), Testes (RPKM 6.7) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pip5kl1 in Genome Data Viewer
    Location:
    3p11
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (36258141..36266902)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (15860493..15869264)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (11592156..11597513)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486072 Neighboring gene estrogen-induced osteoclastogenesis regulator 1 Neighboring gene dolichyl-phosphate mannosyltransferase subunit 2, regulatory Neighboring gene ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 Neighboring gene ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Overexpression of PIP5KL1 suppresses cell proliferation and migration in human gastric cancer cells. Shi L, et al. Mol Biol Rep, 2010 Jun. PMID 19680787
    2. Identification and characterization of a phosphoinositide phosphate kinase homolog. Chang JD, et al. J Biol Chem, 2004 Mar 19. PMID 14701839
    3. Cell-based screening and validation of human novel genes associated with cell viability. Wang L, et al. J Biomol Screen, 2006 Jun. PMID 16751333
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-4-phosphate 5-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 1-phosphatidylinositol-4-phosphate 5-kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of mitochondrial membrane potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylinositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidylinositol 4-phosphate 5-kinase-like protein 1; phosphatidylinositol-4-phosphate 5-kinase-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431771.1 → NP_001418700.1  phosphatidylinositol-4-phosphate 5-kinase-like 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6JU69

    2. NM_001431772.1 → NP_001418701.1  phosphatidylinositol-4-phosphate 5-kinase-like 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6JU69

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      36258141..36266902
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039106178.2 → XP_038962106.1  phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform X1

      Related
      ENSRNOP00000067014.4, ENSRNOT00000074122.4
      Conserved Domains (2) summary
      PHA03307
      Location:16 → 203
      PHA03307; transcriptional regulator ICP4; Provisional
      cd17304
      Location:262 → 604
      PIPKc_PIP5KL1; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in phosphatidylinositol 4-phosphate 5-kinase-like protein 1 (PIP5KL1) and similar proteins

    2. XM_039106179.2 → XP_038962107.1  phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform X2

      Related
      ENSRNOP00000092836.2, ENSRNOT00000109105.2
      Conserved Domains (2) summary
      PHA03307
      Location:16 → 203
      PHA03307; transcriptional regulator ICP4; Provisional
      cd17304
      Location:262 → 586
      PIPKc_PIP5KL1; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in phosphatidylinositol 4-phosphate 5-kinase-like protein 1 (PIP5KL1) and similar proteins

    3. XM_039106180.2 → XP_038962108.1  phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform X3

      Conserved Domains (2) summary
      PRK07764
      Location:12 → 145
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cl28923
      Location:262 → 468
      PIPKc; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain family
    Nucleotide Protein Strain
    Heading Accession and Version

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