Klhl15 kelch-like family member 15 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Klhl15provided by RGD
Official Full Name: kelch-like family member 15provided by RGD
Primary source: RGD:1563101
See related: EnsemblRapid:ENSRNOG00000006515 AllianceGenome:RGD:1563101
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1563101
Summary: Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in negative regulation of double-strand break repair via homologous recombination and nuclear protein quality control by the ubiquitin-proteasome system. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 103. Orthologous to human KLHL15 (kelch like family member 15). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 61.1), Thymus (RPKM 51.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq22

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (62987762..63043980)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (58994726..59050207)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (63342277..63390915)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

DXRat90 (e-PCR), detects polymorphism
- UniSTS:228444

AU049895 (e-PCR)
- UniSTS:146340

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ubiquitin-like ligase-substrate adaptor activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-like ligase-substrate adaptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in negative regulation of double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of double-strand break repair via homologous recombination	ISS Inferred from Sequence or Structural Similarity more info
involved_in nuclear protein quality control by the ubiquitin-proteasome system	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear protein quality control by the ubiquitin-proteasome system	ISO Inferred from Sequence Orthology more info
involved_in nuclear protein quality control by the ubiquitin-proteasome system	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of Cul3-RING ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of Cul3-RING ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: kelch-like protein 15

Names: kelch-like 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108021.2 → NP_001101491.1 kelch-like protein 15

See identical proteins and their annotated locations for NP_001101491.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/Swiss-Prot

D3ZA50

Conserved Domains (4) summary

PHA03098
Location:33 → 576

PHA03098; kelch-like protein; Provisional

sd00038
Location:417 → 474

Kelch; KELCH repeat [structural motif]

cd18244
Location:1 → 137

BTB_POZ_KLHL15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15)

cd18454
Location:128 → 235

BACK_KLHL15; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15)
NM_001434052.1 → NP_001420981.1 kelch-like protein 15

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021
NM_001434053.1 → NP_001420982.1 kelch-like protein 15

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021
NM_001434054.1 → NP_001420983.1 kelch-like protein 15

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021
NM_001434055.1 → NP_001420984.1 kelch-like protein 15

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021
NM_001434057.1 → NP_001420986.1 kelch-like protein 15

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021
NM_001434058.1 → NP_001420987.1 kelch-like protein 15

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

62987762..63043980

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017602042.3 → XP_017457531.1 kelch-like protein 15 isoform X1

UniProtKB/Swiss-Prot

D3ZA50

Conserved Domains (4) summary

PHA03098
Location:33 → 576

PHA03098; kelch-like protein; Provisional

sd00038
Location:417 → 474

Kelch; KELCH repeat [structural motif]

cd18244
Location:1 → 137

BTB_POZ_KLHL15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15)

cd18454
Location:128 → 235

BACK_KLHL15; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15)
XM_063280000.1 → XP_063136070.1 kelch-like protein 15 isoform X1

UniProtKB/Swiss-Prot

D3ZA50
XM_063279995.1 → XP_063136065.1 kelch-like protein 15 isoform X1

UniProtKB/Swiss-Prot

D3ZA50
XM_063279999.1 → XP_063136069.1 kelch-like protein 15 isoform X1

UniProtKB/Swiss-Prot

D3ZA50
XM_063280003.1 → XP_063136073.1 kelch-like protein 15 isoform X4
XM_063280004.1 → XP_063136074.1 kelch-like protein 15 isoform X5
XM_063279994.1 → XP_063136064.1 kelch-like protein 15 isoform X1

UniProtKB/Swiss-Prot

D3ZA50

Related

ENSRNOP00000008558.5, ENSRNOT00000008558.7
XM_039099706.2 → XP_038955634.1 kelch-like protein 15 isoform X1

UniProtKB/Swiss-Prot

D3ZA50

Conserved Domains (4) summary

PHA03098
Location:33 → 576

PHA03098; kelch-like protein; Provisional

sd00038
Location:417 → 474

Kelch; KELCH repeat [structural motif]

cd18244
Location:1 → 137

BTB_POZ_KLHL15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15)

cd18454
Location:128 → 235

BACK_KLHL15; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15)
XM_063279997.1 → XP_063136067.1 kelch-like protein 15 isoform X1

UniProtKB/Swiss-Prot

D3ZA50
XM_063279998.1 → XP_063136068.1 kelch-like protein 15 isoform X1

UniProtKB/Swiss-Prot

D3ZA50
XM_039099705.2 → XP_038955633.1 kelch-like protein 15 isoform X1

UniProtKB/Swiss-Prot

D3ZA50

Conserved Domains (4) summary

PHA03098
Location:33 → 576

PHA03098; kelch-like protein; Provisional

sd00038
Location:417 → 474

Kelch; KELCH repeat [structural motif]

cd18244
Location:1 → 137

BTB_POZ_KLHL15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15)

cd18454
Location:128 → 235

BACK_KLHL15; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15)
XM_063279996.1 → XP_063136066.1 kelch-like protein 15 isoform X1

UniProtKB/Swiss-Prot

D3ZA50
XM_017602041.3 → XP_017457530.1 kelch-like protein 15 isoform X1

UniProtKB/Swiss-Prot

D3ZA50

Conserved Domains (4) summary

PHA03098
Location:33 → 576

PHA03098; kelch-like protein; Provisional

sd00038
Location:417 → 474

Kelch; KELCH repeat [structural motif]

cd18244
Location:1 → 137

BTB_POZ_KLHL15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15)

cd18454
Location:128 → 235

BACK_KLHL15; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15)
XM_063279993.1 → XP_063136063.1 kelch-like protein 15 isoform X1

UniProtKB/Swiss-Prot

D3ZA50
XM_063280001.1 → XP_063136071.1 kelch-like protein 15 isoform X2
XM_063279992.1 → XP_063136062.1 kelch-like protein 15 isoform X1

UniProtKB/Swiss-Prot

D3ZA50
XM_063280002.1 → XP_063136072.1 kelch-like protein 15 isoform X3