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    Homez homeobox and leucine zipper encoding [ Rattus norvegicus (Norway rat) ]

    Gene ID: 260325, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Homezprovided by RGD
    Official Full Name
    homeobox and leucine zipper encodingprovided by RGD
    Primary source
    RGD:628904
    See related
    EnsemblRapid:ENSRNOG00000014887 AllianceGenome:RGD:628904
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA binding activity and DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be active in nucleus. Orthologous to human HOMEZ (homeobox and leucine zipper encoding). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 71.1), Kidney (RPKM 28.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Homez in Genome Data Viewer
    Location:
    15p13
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (32292897..32309564, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (28321633..28339486, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (33510454..33528018, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene ring finger protein 212B Neighboring gene U6 spliceosomal RNA Neighboring gene WW domain-binding protein 11-like Neighboring gene protein phosphatase 1, regulatory subunit 3E Neighboring gene Bcl2-like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Homez, a homeobox leucine zipper gene specific to the vertebrate lineage. Bayarsaihan D, et al. Proc Natl Acad Sci U S A, 2003 Sep 2. PMID 12925734, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Homez is a homeobox leucine zipper gene specific to the vertebrate lineage.
      Title: Homez, a homeobox leucine zipper gene specific to the vertebrate lineage.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Clone Names

    • MGC93137, MGC105306

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    homeobox and leucine zipper protein Homez
    Names
    homeodomain leucine zipper-containing factor
    homeodomain leucine zipper-encoding
    homeodomain-leucine zipper protein HOMEZ

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_152849.2 → NP_690062.3  homeobox and leucine zipper protein Homez

      See identical proteins and their annotated locations for NP_690062.3

      Status: VALIDATED

      Source sequence(s)
      BC084701
      UniProtKB/TrEMBL
      A0A8I6ABU6, F8WFQ4
      Conserved Domains (2) summary
      cd00086
      Location:346 → 403
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam11569
      Location:448 → 495
      Homez; Homeodomain leucine-zipper encoding, Homez

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      32292897..32309564 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063274032.1 → XP_063130102.1  homeobox and leucine zipper protein Homez isoform X3

      Related
      ENSRNOP00000019979.6, ENSRNOT00000019979.6

    2. XM_006251930.5 → XP_006251992.3  homeobox and leucine zipper protein Homez isoform X1

      UniProtKB/Swiss-Prot
      Q8K3E9
      UniProtKB/TrEMBL
      A6KGW4, Q5XFX1
      Conserved Domains (2) summary
      cd00086
      Location:327 → 384
      homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
      pfam11569
      Location:429 → 475
      Homez; Homeodomain leucine-zipper encoding, Homez

    3. XM_008770663.4 → XP_008768885.2  homeobox and leucine zipper protein Homez isoform X2

      UniProtKB/Swiss-Prot
      Q8K3E9
      UniProtKB/TrEMBL
      A6KGW4
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K3E9.1 GenPept UniProtKB/Swiss-Prot:Q8K3E9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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