Hoxb2 homeobox B2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hoxb2provided by RGD
Official Full Name: homeobox B2provided by RGD
Primary source: RGD:2319509
See related: EnsemblRapid:ENSRNOG00000008365 AllianceGenome:RGD:2319509
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Hoxbes2
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including central nervous system development; embryonic skeletal system morphogenesis; and regionalization. Predicted to be located in nucleoplasm. Orthologous to human HOXB2 (homeobox B2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 67.1), Adrenal (RPKM 49.1) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q26

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (81814340..81816731)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (81317828..81320220)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (84200859..84203065)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HOXBES2 expression could be regulated by androgens, and its expression level is closely associated with the postnatal development of the epididymis.
Title: Postnatal expression and androgen regulation of HOXBES2 homeoprotein in rat epididymis.
We have identified and characterized a novel epididymal homeoprotein different from HOXB2 protein and hereafter referred to as HOXBES2, (HOXB2 homeodomain containing epididymis-specific sperm protein) with a probable role in fertilization.
Title: HOXBES2: a novel epididymal HOXB2 homeoprotein and its domain-specific association with spermatozoa.

Submit: New GeneRIF Correction

General gene information

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Markers

RH130477 (e-PCR)
- UniSTS:213761

Hoxb2 (e-PCR), detects polymorphism
- UniSTS:536649

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within anterior/posterior pattern specification	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dorsal/ventral pattern formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic skeletal system morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within facial nerve structural organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within morphogenesis of an epithelial sheet	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neural nucleus development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within rhombomere 3 development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within rhombomere 4 development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skeletal system morphogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: homeobox protein Hox-B2

Names: Hoxb2-like epididymal protein; homeo box B2-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001399735.1 → NP_001386664.1 homeobox protein Hox-B2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A6HIF1, D4A426

Related

ENSRNOP00000011213.5, ENSRNOT00000011213.7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

81814340..81816731

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001047091.1: Suppressed sequence

Description

NM_001047091.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.