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    Calhm6 calcium homeostasis modulator family member 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294430, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Calhm6provided by RGD
    Official Full Name
    calcium homeostasis modulator family member 6provided by RGD
    Primary source
    RGD:1304835
    See related
    EnsemblRapid:ENSRNOG00000037757 AllianceGenome:RGD:1304835
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fam26f; RGD1304835
    Summary
    Predicted to enable monoatomic cation channel activity and voltage-gated channel activity. Predicted to be involved in ATP export and regulation of natural killer cell cytokine production. Predicted to be located in immunological synapse. Predicted to be active in plasma membrane. Orthologous to human CALHM6 (calcium homeostasis modulator family member 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 86.5), Thymus (RPKM 32.2) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Calhm6 in Genome Data Viewer
    Location:
    20q11
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (26638721..26640466, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (26095591..26097336, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (27681138..27683580, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene trafficking protein particle complex subunit 3L Neighboring gene calcium homeostasis modulator family member 4 Neighboring gene calcium homeostasis modulator family member 5 Neighboring gene dermatan sulfate epimerase Neighboring gene eukaryotic translation elongation factor 1 alpha 1, pseudogene 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables monoatomic cation channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables voltage-gated channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables voltage-gated channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in ATP export IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ATP export ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in monoatomic cation transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of natural killer cell cytokine production IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of natural killer cell cytokine production ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in immunological synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in immunological synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    calcium homeostasis modulator protein 6
    Names
    family with sequence similarity 26, member F
    protein FAM26F

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024976.1 → NP_001020147.1  calcium homeostasis modulator protein 6

      See identical proteins and their annotated locations for NP_001020147.1

      Status: PROVISIONAL

      Source sequence(s)
      BC093379
      UniProtKB/Swiss-Prot
      Q561R8
      UniProtKB/TrEMBL
      A6K3S8
      Related
      ENSRNOP00000054134.2, ENSRNOT00000057317.6
      Conserved Domains (1) summary
      pfam14798
      Location:2 → 246
      Ca_hom_mod; Calcium homeostasis modulator

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      26638721..26640466 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008772880.3 → XP_008771102.1  calcium homeostasis modulator protein 6 isoform X1

      Conserved Domains (1) summary
      pfam14798
      Location:4 → 173
      Ca_hom_mod; Calcium homeostasis modulator
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q561R8.1 GenPept UniProtKB/Swiss-Prot:Q561R8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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