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    Ints6 integrator complex subunit 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361057, updated on 27-Dec-2024

    Summary

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    Symbol
    Ints6provided by RGD
    Full Name
    integrator complex subunit 6provided by RGD
    Primary source
    RGD:1309480
    See related
    EnsemblRapid:ENSRNOG00000009873 AllianceGenome:RGD:1309480
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ddx26; LRRGT00024
    Summary
    Predicted to be involved in snRNA 3'-end processing. Predicted to be located in actin cytoskeleton and nucleoplasm. Predicted to be part of integrator complex. Predicted to be active in nucleus. Orthologous to human INTS6 (integrator complex subunit 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 149.9), Thymus (RPKM 141.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ints6 in Genome Data Viewer
    Location:
    15p12
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (41080584..41224350, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (36908966..37048043, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (45844050..45929996, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482129 Neighboring gene family with sequence similarity 124 member A Neighboring gene small nucleolar RNA SNORA17 Neighboring gene serpin family E member 3 Neighboring gene ribosomal protein L38, pseudogene 7 Neighboring gene Sec61 translocon subunit gamma, pseudogene 5 Neighboring gene zinc finger CCCH domain-containing protein 13-like Neighboring gene large ribosomal subunit protein eL27-like Neighboring gene WD repeat and FYVE domain containing 2 Neighboring gene uncharacterized LOC120097010 Neighboring gene ribosomal protein L23a, pseudogene 2 Neighboring gene defensin beta 42

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Nuclear-localized Asunder regulates cytoplasmic dynein localization via its role in the integrator complex. Jodoin JN, et al. Mol Biol Cell, 2013 Sep. PMID 23904267, Free PMC Article
    2. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. Baillat D, et al. Cell, 2005 Oct 21. PMID 16239144
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in snRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in snRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of integrator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of integrator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    integrator complex subunit 6
    Names
    DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271488.1 → NP_001258417.1  integrator complex subunit 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A0A8I6AP01, A6K6E2
      Related
      ENSRNOP00000095908.1, ENSRNOT00000101257.2
      Conserved Domains (2) summary
      pfam13519
      Location:4 → 103
      VWA_2; von Willebrand factor type A domain
      pfam15300
      Location:805 → 864
      INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      41080584..41224350 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063274427.1 → XP_063130497.1  integrator complex subunit 6 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AP01, A6K6E2

    2. XM_063274428.1 → XP_063130498.1  integrator complex subunit 6 isoform X2

      UniProtKB/TrEMBL
      A6K6E2

    3. XM_063274426.1 → XP_063130496.1  integrator complex subunit 6 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AP01, A6K6E2

    4. XM_003751499.6 → XP_003751547.1  integrator complex subunit 6 isoform X2

      UniProtKB/TrEMBL
      A6K6E2
      Conserved Domains (2) summary
      cd00198
      Location:4 → 131
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
      pfam15300
      Location:795 → 854
      INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

    5. XM_039093511.2 → XP_038949439.1  integrator complex subunit 6 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AP01, A6K6E2
      Conserved Domains (2) summary
      pfam13519
      Location:4 → 103
      VWA_2; von Willebrand factor type A domain
      pfam15300
      Location:805 → 864
      INT_SG_DDX_CT_C; INTS6/SAGE1/DDX26B/CT45 C-terminus

    6. XM_063274423.1 → XP_063130493.1  integrator complex subunit 6 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AP01, A6K6E2

    7. XM_063274422.1 → XP_063130492.1  integrator complex subunit 6 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AP01, A6K6E2

    8. XM_063274425.1 → XP_063130495.1  integrator complex subunit 6 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AP01, A6K6E2

    9. XM_063274424.1 → XP_063130494.1  integrator complex subunit 6 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AP01, A6K6E2

    RNA

    1. XR_005493766.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001047904.1: Suppressed sequence

      Description
      NM_001047904.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: INTS6 (GeneID:26512).
    Nucleotide Protein Strain
    Heading Accession and Version

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