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    Spmip6 sperm microtubule inner protein 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500441, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Spmip6provided by RGD
    Official Full Name
    sperm microtubule inner protein 6provided by RGD
    Primary source
    RGD:1561916
    See related
    EnsemblRapid:ENSRNOG00000013320 AllianceGenome:RGD:1561916
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1561916
    Summary
    Predicted to enable alpha-tubulin binding activity. Predicted to be involved in flagellated sperm motility. Predicted to act upstream of or within protein-containing complex assembly. Predicted to be located in several cellular components, including mitochondrion; nucleoplasm; and sperm midpiece. Predicted to be active in microtubule cytoskeleton; perinuclear region of cytoplasm; and sperm flagellum. Orthologous to human SPMIP6 (sperm microtubule inner protein 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 450.3) and Lung (RPKM 35.2) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Spmip6 in Genome Data Viewer
    Location:
    5q22
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (61462070..61474832, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (56666160..56678865, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (57883713..57896449, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene nudix hydrolase 2 Neighboring gene myogenesis regulating glycosidase Neighboring gene uncharacterized LOC102553821 Neighboring gene family with sequence similarity 219, member A Neighboring gene dynein, axonemal, intermediate chain 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of the spermatid-specific Smrp1 gene encoding a novel manchette protein. Matsuoka Y, et al. Mol Reprod Dev, 2008 Jun. PMID 18163442
    2. Characterization of ciliated bronchial epithelium 1, a ciliated cell-associated gene induced during mucociliary differentiation. Yoshisue H, et al. Am J Respir Cell Mol Biol, 2004 Nov. PMID 15242845
    3. Proteomic characterization of the human sperm nucleus. de Mateo S, et al. Proteomics, 2011 Jul. PMID 21630459
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables alpha-tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in flagellated sperm motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axonemal A tubule inner sheath ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in manchette IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in manchette ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in perinuclear region of cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in sperm flagellum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm midpiece ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sperm microtubule inner protein 6
    Names
    spermatid-specific manchette-related protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419511.1 → NP_001406440.1  sperm microtubule inner protein 6 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005

    2. NM_001419512.1 → NP_001406441.1  sperm microtubule inner protein 6 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A6IIV4

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      61462070..61474832 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_575803.9 → XP_575803.4  sperm microtubule inner protein 6 isoform X1

      See identical proteins and their annotated locations for XP_575803.4

      UniProtKB/TrEMBL
      D4A9U1
      Related
      ENSRNOP00000017903.7, ENSRNOT00000017903.10
      Conserved Domains (1) summary
      pfam15181
      Location:1 → 256
      SMRP1; Spermatid-specific manchette-related protein 1

    2. XM_063288217.1 → XP_063144287.1  sperm microtubule inner protein 6 isoform X2

    3. XM_017593717.3 → XP_017449206.3  sperm microtubule inner protein 6 isoform X3

    4. XM_006238116.5 → XP_006238178.1  sperm microtubule inner protein 6 isoform X5

      See identical proteins and their annotated locations for XP_006238178.1

      Conserved Domains (1) summary
      pfam15181
      Location:1 → 122
      SMRP1; Spermatid-specific manchette-related protein 1

    5. XM_063288218.1 → XP_063144288.1  sperm microtubule inner protein 6 isoform X4

      UniProtKB/TrEMBL
      A6IIV5

    6. XM_039110968.2 → XP_038966896.1  sperm microtubule inner protein 6 isoform X4

      UniProtKB/TrEMBL
      A6IIV5
      Conserved Domains (1) summary
      pfam15181
      Location:1 → 157
      SMRP1; Spermatid-specific manchette-related protein 1
    Nucleotide Protein Strain
    Heading Accession and Version

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