Selenos selenoprotein S [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Selenosprovided by RGD
Official Full Name: selenoprotein Sprovided by RGD
Primary source: RGD:628897
See related: AllianceGenome:RGD:628897
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: sg2; Sels; Vimp
Summary: This gene encodes a transmembrane protein that is localized in the endoplasmic reticulum (ER). It is involved in the degradation process of misfolded proteins in the ER, and may also have a role in inflammation control. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Two additional phylogenetically conserved stem-loop structures (Stem-loop 1 and Stem-loop 2) in the 3' UTR of this mRNA have been shown to function as modulators of Sec insertion (PMID:23614019). [provided by RefSeq, Jul 2017]
Expression: Biased expression in Kidney (RPKM 251.2), Lung (RPKM 234.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q22

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (129070240..129080007)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (119659779..119669546)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (126979579..126989344)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Selenoprotein S Is Highly Expressed in the Blood Vessels and Prevents Vascular Smooth Muscle Cells From Apoptosis
Title: Selenoprotein S Is Highly Expressed in the Blood Vessels and Prevents Vascular Smooth Muscle Cells From Apoptosis.
we propose that the upregulation of Sels represents a reaction of astrocytes against inflammatory stimuli
Title: Selenoprotein S expression in the rat brain following focal cerebral ischemia.
High expression of Tanis mRNA in the liver is associated with the development of insulin resistance probably via the function of SAA1.
Title: Upregulation of Tanis mRNA expression in the liver is associated with insulin resistance in rats.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATPase binding	IEA Inferred from Electronic Annotation more info
enables ATPase binding	ISO Inferred from Sequence Orthology more info
enables antioxidant activity	IEA Inferred from Electronic Annotation more info
enables antioxidant activity	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin-specific protease binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin-specific protease binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ER overload response	IEA Inferred from Electronic Annotation more info
involved_in ER overload response	ISO Inferred from Sequence Orthology more info
involved_in ERAD pathway	ISO Inferred from Sequence Orthology more info
involved_in cell redox homeostasis	IEA Inferred from Electronic Annotation more info
involved_in cell redox homeostasis	ISO Inferred from Sequence Orthology more info
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
involved_in cellular response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
involved_in cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to oxidative stress	IEA Inferred from Electronic Annotation more info
involved_in cellular response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in endoplasmic reticulum unfolded protein response	IBA Inferred from Biological aspect of Ancestor more info
involved_in endoplasmic reticulum unfolded protein response	IEA Inferred from Electronic Annotation more info
involved_in endoplasmic reticulum unfolded protein response	ISO Inferred from Sequence Orthology more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of acute inflammatory response to antigenic stimulus	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of acute inflammatory response to antigenic stimulus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-6 production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of macrophage apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of macrophage apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of tumor necrosis factor production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in regulation of nitric oxide metabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of nitric oxide metabolic process	ISO Inferred from Sequence Orthology more info
involved_in response to glucose	IEA Inferred from Electronic Annotation more info
involved_in response to glucose	ISO Inferred from Sequence Orthology more info
involved_in response to redox state	IEA Inferred from Electronic Annotation more info
involved_in response to redox state	ISO Inferred from Sequence Orthology more info
involved_in retrograde protein transport, ER to cytosol	IBA Inferred from Biological aspect of Ancestor more info
involved_in retrograde protein transport, ER to cytosol	IEA Inferred from Electronic Annotation more info
involved_in retrograde protein transport, ER to cytosol	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Derlin-1 retrotranslocation complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Derlin-1 retrotranslocation complex	IEA Inferred from Electronic Annotation more info
part_of Derlin-1 retrotranslocation complex	ISO Inferred from Sequence Orthology more info
part_of Derlin-1-VIMP complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Derlin-1-VIMP complex	IEA Inferred from Electronic Annotation more info
part_of Derlin-1-VIMP complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic microtubule	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic microtubule	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic microtubule	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
part_of low-density lipoprotein particle	IEA Inferred from Electronic Annotation more info
part_of low-density lipoprotein particle	ISO Inferred from Sequence Orthology more info
part_of very-low-density lipoprotein particle	IEA Inferred from Electronic Annotation more info
part_of very-low-density lipoprotein particle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: selenoprotein S

Names: Tanis; VCP-interacting membrane protein; VCP-interacting membrane selenoprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173120.2 → NP_775143.2 selenoprotein S

Status: REVIEWED

Source sequence(s)

AF367467, BC059111

UniProtKB/TrEMBL

A0A8I6AMI0, A6JBP7

Conserved Domains (1) summary

pfam06936
Location:1 → 188

Selenoprotein_S; Selenoprotein S (SelS)