Mapk3 mitogen activated protein kinase 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mapk3provided by RGD
Official Full Name: mitogen activated protein kinase 3provided by RGD
Primary source: RGD:3046
See related: EnsemblRapid:ENSRNOG00000053583 AllianceGenome:RGD:3046
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: p44; ERK1; ERT2; MNK1; Erk-1; Esrk1; MAPK1; Prkm3; p44erk1; p44mapk
Summary: Enables ATP binding activity; MAP kinase activity; and scaffold protein binding activity. Involved in several processes, including arachidonate metabolic process; decidualization; and peptidyl-serine phosphorylation. Located in caveola; cytoplasm; and nucleoplasm. Part of protein-containing complex. Used to study several diseases, including alcohol dependence; cocaine abuse; drug dependence (multiple); gastric ulcer; and middle cerebral artery infarction. Biomarker of alcohol use disorder. Human ortholog(s) of this gene implicated in Parkinson's disease; carcinoma (multiple); and pulmonary hypertension. Orthologous to human MAPK3 (mitogen-activated protein kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 210.4), Brain (RPKM 104.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q36

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (190797189..190803411)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (181366646..181372863)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (198192773..198198975)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ERK1/2 Regulates Epileptic Seizures by Modulating the DRP1-Mediated Mitochondrial Dynamic.
Title: ERK1/2 Regulates Epileptic Seizures by Modulating the DRP1-Mediated Mitochondrial Dynamic.
Inhibition of ERK1/2 or CRMP2 Disrupts Alcohol Memory Reconsolidation and Prevents Relapse in Rats.
Title: Inhibition of ERK1/2 or CRMP2 Disrupts Alcohol Memory Reconsolidation and Prevents Relapse in Rats.
Role of PI3K, ERK1/2, and JAK2 Kinases in the Cardioprotective Effect of Deltorphin II during Cardiac Reperfusion.
Title: Role of PI3K, ERK1/2, and JAK2 Kinases in the Cardioprotective Effect of Deltorphin II during Cardiac Reperfusion.
Cyclic tensile force modifies calvarial osteoblast function via the interplay between ERK1/2 and STAT3.
Title: Cyclic tensile force modifies calvarial osteoblast function via the interplay between ERK1/2 and STAT3.
Blocking P2RX7 Attenuates Ferroptosis in Endothelium and Reduces HG-induced Hemorrhagic Transformation After MCAO by Inhibiting ERK1/2 and P53 Signaling Pathways.
Title: Blocking P2RX7 Attenuates Ferroptosis in Endothelium and Reduces HG-induced Hemorrhagic Transformation After MCAO by Inhibiting ERK1/2 and P53 Signaling Pathways.
Diabetes Induces Permanent Deleterious Effects in the Olfactory Bulb Associated with Increased Tyrosine Hydroxylase Expression and ERK1/2 Phosphorylation.
Title: Diabetes Induces Permanent Deleterious Effects in the Olfactory Bulb Associated with Increased Tyrosine Hydroxylase Expression and ERK1/2 Phosphorylation.
Inhibition of ERK1/2 regulates cognitive function by decreasing expression levels of PSD-95 in the hippocampus of CIH rats.
Title: Inhibition of ERK1/2 regulates cognitive function by decreasing expression levels of PSD-95 in the hippocampus of CIH rats.
The ERK phosphorylation levels in the amygdala predict anxiety symptoms in humans and MEK/ERK inhibition dissociates innate and learned defensive behaviors in rats.
Title: The ERK phosphorylation levels in the amygdala predict anxiety symptoms in humans and MEK/ERK inhibition dissociates innate and learned defensive behaviors in rats.
Wogonoside attenuates the articular cartilage injury and the infiltration of Th1/Th2-type cytokines in papain-induced osteoarthritis in rat model via inhibiting the NF-kappaB and ERK1/2 activation.
Title: Wogonoside attenuates the articular cartilage injury and the infiltration of Th1/Th2-type cytokines in papain-induced osteoarthritis in rat model via inhibiting the NF-κB and ERK1/2 activation.
miR-375 induces adipogenesis through targeting Erk1 in pancreatic duct cells under the influence of sodium palmitate.
Title: miR-375 induces adipogenesis through targeting Erk1 in pancreatic duct cells under the influence of sodium palmitate.

Submit: New GeneRIF Correction See all GeneRIFs (583)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Prkm3-rs1 (e-PCR), detects polymorphism
- UniSTS:144262

Mapk3 (e-PCR), detects polymorphism
- UniSTS:507052

BI278071 (e-PCR)
- UniSTS:244204

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables JUN kinase activity	IEA Inferred from Electronic Annotation more info
enables MAP kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables MAP kinase activity	IEA Inferred from Electronic Annotation more info
enables MAP kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables MAP kinase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables phosphatase binding	ISO Inferred from Sequence Orthology more info
enables phosphotyrosine residue binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IC Inferred by Curator more info	PubMed
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables scaffold protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within Bergmann glial cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in ERBB2-ERBB3 signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in JNK cascade	IEA Inferred from Electronic Annotation more info
involved_in MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in Schwann cell development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within animal organ morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in arachidonate metabolic process	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within cardiac neural crest cell development involved in heart development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cartilage development	ISO Inferred from Sequence Orthology more info
involved_in caveolin-mediated endocytosis	IEA Inferred from Electronic Annotation more info
involved_in caveolin-mediated endocytosis	TAS Traceable Author Statement more info	PubMed
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to amino acid starvation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to mechanical stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to toxic substance	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to tumor necrosis factor	ISO Inferred from Sequence Orthology more info
involved_in decidualization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within face development	ISO Inferred from Sequence Orthology more info
involved_in insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in insulin-like growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-1-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular signal transduction	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within lipopolysaccharide-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in myelination	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neural crest cell development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within outer ear morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-serine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-tyrosine autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cyclase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of macrophage chemotaxis	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of macrophage proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of telomere maintenance	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of translation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of xenophagy	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	TAS Traceable Author Statement more info	PubMed
involved_in protein-containing complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of Golgi inheritance	IEA Inferred from Electronic Annotation more info
involved_in regulation of Golgi inheritance	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within regulation of cellular pH	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of cytoskeleton organization	TAS Traceable Author Statement more info	PubMed
involved_in regulation of early endosome to late endosome transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of early endosome to late endosome transport	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within regulation of ossification	ISO Inferred from Sequence Orthology more info
involved_in regulation of stress-activated MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in regulation of stress-activated MAPK cascade	TAS Traceable Author Statement more info	PubMed
involved_in response to epidermal growth factor	ISO Inferred from Sequence Orthology more info
involved_in response to epidermal growth factor	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within response to exogenous dsRNA	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in response to toxic substance	IDA Inferred from Direct Assay more info	PubMed
involved_in sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in signal transduction in response to DNA damage	ISO Inferred from Sequence Orthology more info
involved_in stress-activated MAPK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within thymus development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within thyroid gland development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within trachea formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of xenophagy	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	TAS Traceable Author Statement more info	PubMed
located_in caveola	IDA Inferred from Direct Assay more info	PubMed
located_in caveola	IEA Inferred from Electronic Annotation more info
located_in caveola	TAS Traceable Author Statement more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	TAS Traceable Author Statement more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info	PubMed
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in early endosome	TAS Traceable Author Statement more info	PubMed
located_in focal adhesion	IEA Inferred from Electronic Annotation more info
located_in focal adhesion	TAS Traceable Author Statement more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in late endosome	IEA Inferred from Electronic Annotation more info
located_in late endosome	TAS Traceable Author Statement more info	PubMed
located_in mitochondrion	TAS Traceable Author Statement more info	PubMed
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	TAS Traceable Author Statement more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
located_in pseudopodium	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mitogen-activated protein kinase 3

Names: MAP kinase 1; MAP kinase 3; MAPK 1; MAPK 3; extracellular signal-regulated kinase 1; insulin-stimulated MAP2 kinase; microtubule-associated protein 2 kinase; mitogen-activated 3; mitogen-activated protein kinase 1

NP_059043.2

EC 2.7.11.24

XP_038944453.1

EC 2.7.11.24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017347.3 → NP_059043.2 mitogen-activated protein kinase 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

P21708, Q4PIY8, Q62686, Q9JJ13

UniProtKB/TrEMBL

A0A8L2R3C3

Related

ENSRNOP00000026688.8, ENSRNOT00000026688.8

Conserved Domains (1) summary

cd07849
Location:37 → 371

STKc_ERK1_2_like; Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

190797189..190803411

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039088525.2 → XP_038944453.1 mitogen-activated protein kinase 3 isoform X1

UniProtKB/TrEMBL

A0A8L2R3C3

Related

ENSRNOP00000110992.1, ENSRNOT00000165309.1

Conserved Domains (1) summary

cd07849
Location:37 → 397

STKc_ERK1_2_like; Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases