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    Msto1 misato mitochondrial distribution and morphology regulator 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 295237, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Msto1provided by RGD
    Official Full Name
    misato mitochondrial distribution and morphology regulator 1provided by RGD
    Primary source
    RGD:1306110
    See related
    EnsemblRapid:ENSRNOG00000020357 AllianceGenome:RGD:1306110
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1306110
    Summary
    Predicted to be involved in mitochondrion distribution; mitochondrion organization; and positive regulation of mitochondrial fusion. Predicted to be located in mitochondrial outer membrane. Predicted to be active in cytosol and mitochondrion. Orthologous to human MSTO1 (misato mitochondrial distribution and morphology regulator 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 43.6), Testes (RPKM 43.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Msto1 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (176603755..176608037, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (174305945..174310230, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (188212211..188216482, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene Ras-like without CAAX 1 Neighboring gene synaptotagmin 11 Neighboring gene gon-4 like Neighboring gene death associated protein 3 Neighboring gene ASH1 like histone lysine methyltransferase Neighboring gene guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Human Misato regulates mitochondrial distribution and morphology. Kimura M, et al. Exp Cell Res, 2007 Apr 15. PMID 17349998
    2. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in mitochondrion distribution ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrion organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mitochondrial fusion ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein misato homolog 1
    Names
    misato 1, mitochondrial distribution and morphology regulator
    misato homolog 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106443.1 → NP_001099913.1  protein misato homolog 1

      See identical proteins and their annotated locations for NP_001099913.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473976
      UniProtKB/TrEMBL
      A6J6A9, A6J6B0, D3ZMW3
      Related
      ENSRNOP00000027579.4, ENSRNOT00000027579.6
      Conserved Domains (1) summary
      cd06060
      Location:6 → 547
      misato; Misato segment II tubulin-like domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      176603755..176608037 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039102035.2 → XP_038957963.1  protein misato homolog 1 isoform X1

      UniProtKB/TrEMBL
      A6J6A9
      Conserved Domains (1) summary
      cd06060
      Location:6 → 587
      misato; Misato segment II tubulin-like domain
    Nucleotide Protein Strain
    Heading Accession and Version

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