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    Sars2 seryl-tRNA synthetase 2, mitochondrial [ Rattus norvegicus (Norway rat) ]

    Gene ID: 292759, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Sars2provided by RGD
    Official Full Name
    seryl-tRNA synthetase 2, mitochondrialprovided by RGD
    Primary source
    RGD:1309456
    See related
    EnsemblRapid:ENSRNOG00000019962 AllianceGenome:RGD:1309456
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable serine-tRNA ligase activity and tRNA binding activity. Predicted to be involved in mitochondrial seryl-tRNA aminoacylation. Predicted to be active in cytosol and mitochondrion. Orthologous to human SARS2 (seryl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 75.8), Heart (RPKM 59.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sars2 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (93156514..93171943)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (84028972..84040725)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (86923769..86935506)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene MARCKS-related protein-like Neighboring gene F-box protein 17 Neighboring gene mitochondrial ribosomal protein S12 Neighboring gene NFKB inhibitor beta Neighboring gene coiled-coil glutamate-rich protein 2 Neighboring gene sirtuin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mutations in the mitochondrial seryl-tRNA synthetase cause hyperuricemia, pulmonary hypertension, renal failure in infancy and alkalosis, HUPRA syndrome. Belostotsky R, et al. Am J Hum Genet, 2011 Feb 11. PMID 21255763, Free PMC Article
    2. Genomic organization, expression, and subcellular localization of mouse mitochondrial seryl-tRNA synthetase. Gibbons WJ Jr, et al. Biochem Biophys Res Commun, 2004 May 7. PMID 15081407
    3. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial seryl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine--tRNA ligase, mitochondrial
    Names
    seryl-aminoacyl-tRNA synthetase 2
    seryl-tRNA synthetase, mitochondrial
    NP_001099710.1
    XP_063139456.1
    XP_063139457.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106240.1 → NP_001099710.1  serine--tRNA ligase, mitochondrial

      See identical proteins and their annotated locations for NP_001099710.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473979
      UniProtKB/TrEMBL
      A0A8I5ZQR8, A6J9K5, D3ZM09
      Related
      ENSRNOP00000027166.4, ENSRNOT00000027166.8
      Conserved Domains (3) summary
      PRK05431
      Location:67 → 493
      PRK05431; seryl-tRNA synthetase; Provisional
      cd00770
      Location:185 → 485
      SerRS_core; Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound ...
      cl12057
      Location:67 → 172
      Seryl_tRNA_N; Seryl-tRNA synthetase N-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      93156514..93171943
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283386.1 → XP_063139456.1  serine--tRNA ligase, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZQR8

    2. XM_063283387.1 → XP_063139457.1  serine--tRNA ligase, mitochondrial isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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