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    Cimap3 ciliary microtubule associated protein 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 691223, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cimap3provided by RGD
    Official Full Name
    ciliary microtubule associated protein 3provided by RGD
    Primary source
    RGD:1586282
    See related
    EnsemblRapid:ENSRNOG00000016842 AllianceGenome:RGD:1586282
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pifo
    Summary
    Predicted to enable cytoskeletal protein binding activity and enzyme binding activity. Predicted to be involved in positive regulation of kinase activity and regulation of cell projection organization. Predicted to act upstream of or within with a positive effect on cilium organization. Predicted to act upstream of or within embryonic heart tube left/right pattern formation. Predicted to be located in trans-Golgi network. Orthologous to human CIMAP3 (ciliary microtubule associated protein 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 179.2) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cimap3 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (196164103..196181466, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (193475785..193493092, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (208616592..208633961, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485667 Neighboring gene WD repeat domain 77 Neighboring gene chitinase, acidic, pseudogene 1 Neighboring gene MLV-related proviral Env polyprotein-like, pseudogene 3 Neighboring gene peroxiredoxin 1-like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Pitchfork regulates primary cilia disassembly and left-right asymmetry. Kinzel D, et al. Dev Cell, 2010 Jul 20. PMID 20643351, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables beta-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cytoskeletal protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables gamma-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kinesin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within_positive_effect cilium organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within embryonic heart tube left/right pattern formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell projection organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell projection organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in ciliary basal body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein pitchfork; ciliary microtubule-associated protein 3
    Names
    primary cilia formation

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001433263.1 → NP_001420192.1  protein pitchfork isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      D3ZDE7

    2. NM_001433264.1 → NP_001420193.1  protein pitchfork isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A6HUP5, D3ZM79

    3. NM_001433265.1 → NP_001420194.1  protein pitchfork isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002

    RNA

    1. NR_197347.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002

    2. NR_197348.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      196164103..196181466 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039103823.2 → XP_038959751.1  ciliary microtubule-associated protein 3 isoform X3

    2. XM_003749376.6 → XP_003749424.1  ciliary microtubule-associated protein 3 isoform X1

      Related
      ENSRNOP00000048012.2, ENSRNOT00000049155.7

    3. XM_001077265.8 → XP_001077265.2  ciliary microtubule-associated protein 3 isoform X2

      Related
      ENSRNOP00000022731.2, ENSRNOT00000022731.7
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
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