Spdya speedy/RINGO cell cycle regulator family member A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Spdyaprovided by RGD
Official Full Name: speedy/RINGO cell cycle regulator family member Aprovided by RGD
Primary source: RGD:621730
See related: EnsemblRapid:ENSRNOG00000004534 AllianceGenome:RGD:621730
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gs4; Lm23; Spy1; Spdy1
Summary: Predicted to enable protein kinase activator activity and protein kinase binding activity. Predicted to be involved in several processes, including G1/S transition of mitotic cell cycle; male meiotic nuclear division; and positive regulation of cell cycle. Predicted to act upstream of or within several processes, including chromosome organization; establishment of protein localization to telomere; and spermatogenesis. Predicted to be located in chromosome; endoplasmic reticulum exit site; and nuclear envelope. Predicted to be active in nucleoplasm. Orthologous to human SPDYA (speedy/RINGO cell cycle regulator family member A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 102.9), Brain (RPKM 17.3) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q14

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (29619415..29675030, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (23905574..23954926, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (23493686..23543236, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LM23 played a protective role in H2O2-induced apoptosis of 293T cells, mediated at least in part through the Akt/PI3K signal pathway; these results provide new insights into the role of LM23 in the development of the testes and spermatogenesis.
Title: Role of LM23 in cell proliferation and apoptosis and its expression during the testis development.
Spy1 participated in the pathological process response to sciatic nerve injury and may be associated with Schwann cells proliferation and axons regeneration.
Title: Temporal-spatial expressions of Spy1 in rat sciatic nerve after crush.
In the hippocampus, SpeedyRINGO acts as a savior for neurons that are under apoptosis.
Title: SpeedyRINGO inhibits calpain-directed apoptosis in neurons.
Peripheral nerve injury induced an up-regulation of Spy1 in lumbar spinal cord, which was associated with glial proliferation.
Title: Peripheral nerve lesion induces an up-regulation of Spy1 in rat spinal cord.
testis-specific gene LM23 identified & characterized from rat type A spermatogonia, pachytene spermatocytes, & round spermatids.
Title: Identification and characterization of a novel spermatogenesis related gene LM23 in rat testis.
LM23 is essential for spermatogenesis in Rattus norvegicus.
Title: LM23 is essential for spermatogenesis in Rattus norvegicus.

Submit: New GeneRIF Correction

General gene information

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Markers

NoName (e-PCR)
- UniSTS:493189

RH138243 (e-PCR)
- UniSTS:220330

RH133497 (e-PCR)
- UniSTS:216780

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein kinase activator activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in G1/S transition of mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within establishment of protein localization to telomere	ISO Inferred from Sequence Orthology more info
involved_in male meiotic nuclear division	ISO Inferred from Sequence Orthology more info
involved_in male meiotic nuclear division	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within meiotic attachment of telomere to nuclear envelope	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within oogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of meiotic cell cycle process involved in oocyte maturation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein kinase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spermatogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within telomere capping	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in XY body	ISO Inferred from Sequence Orthology more info
located_in chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum exit site	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: speedy protein A

Names: RINGO A; rapid inducer of G2/M progression in oocytes A; speedy homolog 1; speedy homolog A; speedy-1; spermatogenesis related protein Gs4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_138855.2 → NP_620210.1 speedy protein A

See identical proteins and their annotated locations for NP_620210.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000006

UniProtKB/Swiss-Prot

Q68G34, Q8R496

UniProtKB/TrEMBL

A6HA23

Related

ENSRNOP00000006073.2, ENSRNOT00000006073.7

Conserved Domains (1) summary

pfam11357
Location:68 → 198

Spy1; Cell cycle regulatory protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

29619415..29675030 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039111749.2 → XP_038967677.1 speedy protein A isoform X1

Related

ENSRNOP00000110560.1, ENSRNOT00000141813.1

Conserved Domains (2) summary

pfam11357
Location:68 → 198

Spy1; Cell cycle regulatory protein

cl28904
Location:283 → 303

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_039111751.2 → XP_038967679.1 speedy protein A isoform X4

Conserved Domains (2) summary

pfam11357
Location:1 → 111

Spy1; Cell cycle regulatory protein

cl28904
Location:196 → 216

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_039111750.2 → XP_038967678.1 speedy protein A isoform X1

Conserved Domains (2) summary

pfam11357
Location:68 → 198

Spy1; Cell cycle regulatory protein

cl28904
Location:283 → 303

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_017594029.3 → XP_017449518.1 speedy protein A isoform X1

Conserved Domains (2) summary

pfam11357
Location:68 → 198

Spy1; Cell cycle regulatory protein

cl28904
Location:283 → 303

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
XM_063261529.1 → XP_063117599.1 speedy protein A isoform X4
XM_006239768.5 → XP_006239830.1 speedy protein A isoform X3

See identical proteins and their annotated locations for XP_006239830.1

UniProtKB/Swiss-Prot

Q8R496

Conserved Domains (1) summary

pfam11357
Location:68 → 198

Spy1; Cell cycle regulatory protein
XM_063261530.1 → XP_063117600.1 speedy protein A isoform X2

UniProtKB/Swiss-Prot

Q68G34, Q8R496

UniProtKB/TrEMBL

A6HA23
XM_063261527.1 → XP_063117597.1 speedy protein A isoform X2

UniProtKB/Swiss-Prot

Q68G34, Q8R496

UniProtKB/TrEMBL

A6HA23