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    Rpp14 ribonuclease P/MRP subunit p14 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361020, updated on 9-Dec-2024

    Summary

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    Symbol
    Rpp14provided by RGD
    Full Name
    ribonuclease P/MRP subunit p14provided by RGD
    Primary source
    RGD:1305436
    See related
    AllianceGenome:RGD:1305436
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ribonuclease P RNA binding activity. Predicted to contribute to ribonuclease P activity. Predicted to be involved in tRNA 5'-leader removal. Predicted to be located in mitochondrion. Predicted to be part of multimeric ribonuclease P complex. Predicted to be active in nucleolus. Orthologous to human RPP14 (ribonuclease P/MRP subunit p14). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 141.1), Thymus (RPKM 115.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rpp14 in Genome Data Viewer
    Location:
    15p14
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (19268025..19278216, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (16837796..16847970, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (18625963..18636157, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene pyruvate dehydrogenase E1 subunit beta Neighboring gene PX domain containing serine/threonine kinase like Neighboring gene abhydrolase domain containing 6, acylglycerol lipase Neighboring gene deoxyribonuclease 1L3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Localization in the nucleolus and coiled bodies of protein subunits of the ribonucleoprotein ribonuclease P. Jarrous N, et al. J Cell Biol, 1999 Aug 9. PMID 10444065, Free PMC Article
    2. Unexpected diversity of RNase P, an ancient tRNA processing enzyme: challenges and prospects. Lai LB, et al. FEBS Lett, 2010 Jan 21. PMID 19931535, Free PMC Article
    3. Oxygen and glucose deprivation induces widespread alterations in mRNA translation within 20 minutes. Andreev DE, et al. Genome Biol, 2015 May 6. PMID 25943107, Free PMC Article
    4. Differential association of protein subunits with the human RNase MRP and RNase P complexes. Welting TJ, et al. RNA, 2006 Jul. PMID 16723659, Free PMC Article
    5. Cryo-EM Structure of the Human Ribonuclease P Holoenzyme. Wu J, et al. Cell, 2018 Nov 15. PMID 30454648

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables hydro-lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribonuclease P RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribonuclease P RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to ribonuclease P activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in tRNA 5'-leader removal IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA 5'-leader removal ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of multimeric ribonuclease P complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of multimeric ribonuclease P complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ribonuclease P protein subunit p14
    Names
    ribonuclease P 14 subunit homolog
    ribonuclease P 14kDa subunit
    ribonuclease P/MRP 14 subunit
    NP_001101842.2
    NP_001135401.1
    XP_008768774.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108372.3 → NP_001101842.2  ribonuclease P protein subunit p14

      See identical proteins and their annotated locations for NP_001101842.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      D4A157
      Conserved Domains (1) summary
      pfam01900
      Location:28 → 106
      RNase_P_Rpp14; Rpp14/Pop5 family

    2. NM_001141929.2 → NP_001135401.1  ribonuclease P protein subunit p14

      See identical proteins and their annotated locations for NP_001135401.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      D4A157
      Conserved Domains (1) summary
      pfam01900
      Location:28 → 106
      RNase_P_Rpp14; Rpp14/Pop5 family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      19268025..19278216 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008770552.4 → XP_008768774.1  ribonuclease P protein subunit p14 isoform X1

      See identical proteins and their annotated locations for XP_008768774.1

      UniProtKB/TrEMBL
      D4A157
      Conserved Domains (1) summary
      pfam01900
      Location:28 → 106
      RNase_P_Rpp14; Rpp14/Pop5 family
    Nucleotide Protein Strain
    Heading Accession and Version

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