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    Lrguk leucine-rich repeats and guanylate kinase domain containing [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296968, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lrgukprovided by RGD
    Official Full Name
    leucine-rich repeats and guanylate kinase domain containingprovided by RGD
    Primary source
    RGD:1308226
    See related
    EnsemblRapid:ENSRNOG00000008775 AllianceGenome:RGD:1308226
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1308226
    Summary
    Predicted to enable guanylate kinase activity. Predicted to be involved in axoneme assembly and spermatogenesis. Predicted to be located in acrosomal vesicle and manchette. Predicted to be active in cytosol. Orthologous to human LRGUK (leucine rich repeats and guanylate kinase domain containing). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 21.3), Lung (RPKM 10.5) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lrguk in Genome Data Viewer
    Location:
    4q22
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (63614431..63737463)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (62647222..62770268)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (61419987..61544748)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene exocyst complex component 4 Neighboring gene FAD-linked sulfhydryl oxidase ALR-like Neighboring gene similar to catechol-O-methyltransferase domain containing 1 Neighboring gene solute carrier family 35 member B4 Neighboring gene NADH:ubiquinone oxidoreductase subunit AB1, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. LRGUK-1 is required for basal body and manchette function during spermatogenesis and male fertility. Liu Y, et al. PLoS Genet, 2015 Mar. PMID 25781171, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables guanylate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in GDP metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in GMP metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in axoneme assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in acrosomal vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in manchette ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat and guanylate kinase domain-containing protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106589.2 → NP_001100059.1  leucine-rich repeat and guanylate kinase domain-containing protein isoform 2

      See identical proteins and their annotated locations for NP_001100059.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A6IEK9, D4A3R3
      Conserved Domains (6) summary
      cd00071
      Location:415 → 591
      GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...
      cd00116
      Location:149 → 338
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:129 → 149
      LRR_RI; leucine-rich repeat [structural motif]
      pfam00625
      Location:416 → 598
      Guanylate_kin; Guanylate kinase
      pfam12799
      Location:259 → 299
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:281 → 338
      LRR_8; Leucine rich repeat

    2. NM_001401524.2 → NP_001388453.1  leucine-rich repeat and guanylate kinase domain-containing protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A8I6GHE9
      Related
      ENSRNOP00000088777.1, ENSRNOT00000108064.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      63614431..63737463
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017592528.3 → XP_017448017.1  leucine-rich repeat and guanylate kinase domain-containing protein isoform X1

    2. XM_017592530.3 → XP_017448019.1  leucine-rich repeat and guanylate kinase domain-containing protein isoform X4

      UniProtKB/TrEMBL
      D4A3R3

    3. XM_063285744.1 → XP_063141814.1  leucine-rich repeat and guanylate kinase domain-containing protein isoform X5

      UniProtKB/TrEMBL
      A0A0G2JWS1, D4A3R3
      Related
      ENSRNOP00000069992.2, ENSRNOT00000082175.3

    4. XM_006236253.5 → XP_006236315.1  leucine-rich repeat and guanylate kinase domain-containing protein isoform X3

      UniProtKB/TrEMBL
      D4A3R3
      Related
      ENSRNOP00000011692.8, ENSRNOT00000011692.8
      Conserved Domains (6) summary
      cd00071
      Location:416 → 592
      GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...
      cd00116
      Location:149 → 339
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:129 → 149
      LRR_RI; leucine-rich repeat [structural motif]
      pfam00625
      Location:417 → 599
      Guanylate_kin; Guanylate kinase
      pfam12799
      Location:260 → 300
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:282 → 339
      LRR_8; Leucine rich repeat

    5. XM_039107286.2 → XP_038963214.1  leucine-rich repeat and guanylate kinase domain-containing protein isoform X7

      UniProtKB/TrEMBL
      D4A3R3
      Conserved Domains (4) summary
      cd00071
      Location:416 → 592
      GMPK; Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine ...
      sd00033
      Location:129 → 149
      LRR_RI; leucine-rich repeat [structural motif]
      NF033189
      Location:130 → 258
      internalin_A; class 1 internalin InlA
      cd21340
      Location:200 → 369
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    6. XM_039107288.2 → XP_038963216.1  leucine-rich repeat and guanylate kinase domain-containing protein isoform X12

      Conserved Domains (4) summary
      sd00033
      Location:129 → 149
      LRR_RI; leucine-rich repeat [structural motif]
      NF033189
      Location:130 → 258
      internalin_A; class 1 internalin InlA
      cd21340
      Location:200 → 369
      PPP1R42; protein phosphatase 1 regulatory subunit 42
      cl17190
      Location:416 → 475
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    7. XM_039107289.2 → XP_038963217.1  leucine-rich repeat and guanylate kinase domain-containing protein isoform X13

      Conserved Domains (4) summary
      sd00033
      Location:129 → 149
      LRR_RI; leucine-rich repeat [structural motif]
      NF033189
      Location:130 → 258
      internalin_A; class 1 internalin InlA
      cd21340
      Location:200 → 369
      PPP1R42; protein phosphatase 1 regulatory subunit 42
      cl17190
      Location:416 → 448
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    8. XM_063285745.1 → XP_063141815.1  leucine-rich repeat and guanylate kinase domain-containing protein isoform X8

      UniProtKB/TrEMBL
      D4A3R3
      Related
      ENSRNOP00000105002.1, ENSRNOT00000152530.1

    9. XM_017592531.3 → XP_017448020.1  leucine-rich repeat and guanylate kinase domain-containing protein isoform X10

    10. XM_063285746.1 → XP_063141816.1  leucine-rich repeat and guanylate kinase domain-containing protein isoform X11

    11. XM_063285743.1 → XP_063141813.1  leucine-rich repeat and guanylate kinase domain-containing protein isoform X2

    12. XM_039107285.2 → XP_038963213.1  leucine-rich repeat and guanylate kinase domain-containing protein isoform X6

      Conserved Domains (2) summary
      PHA03247
      Location:207 → 705
      PHA03247; large tegument protein UL36; Provisional
      cl17190
      Location:1 → 126
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    13. XM_039107287.2 → XP_038963215.1  leucine-rich repeat and guanylate kinase domain-containing protein isoform X9

      Conserved Domains (2) summary
      PHA03247
      Location:169 → 667
      PHA03247; large tegument protein UL36; Provisional
      cl17190
      Location:2 → 88
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

    RNA

    1. XR_005503178.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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