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    Immt inner membrane mitochondrial protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 312444, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Immtprovided by RGD
    Official Full Name
    inner membrane mitochondrial proteinprovided by RGD
    Primary source
    RGD:1310684
    See related
    EnsemblRapid:ENSRNOG00000009097 AllianceGenome:RGD:1310684
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in cristae formation. Predicted to act upstream of or within mitochondrial calcium ion homeostasis and neuron cellular homeostasis. Predicted to be located in mitochondrial inner membrane and mitochondrial intermembrane space. Predicted to be part of MICOS complex. Orthologous to human IMMT (inner membrane mitochondrial protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 1158.9), Kidney (RPKM 790.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Immt in Genome Data Viewer
    Location:
    4q32
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (105438657..105477370)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (103880482..103919116)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (99753446..99789921)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486590 Neighboring gene receptor accessory protein 1 Neighboring gene mitochondrial ribosomal protein L35 Neighboring gene small nucleolar RNA, C/D box 94 Neighboring gene Pentatricopeptide repeat domain 3 Neighboring gene RNA polymerase I subunit A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Loss of MIC60 Aggravates Neuronal Death by Inducing Mitochondrial Dysfunction in a Rat Model of Intracerebral Hemorrhage. Deng R, et al. Mol Neurobiol, 2021 Oct. PMID 34232477
    2. Mitoproteome plasticity of rat brown adipocytes in response to cold acclimation. Navet R, et al. J Proteome Res, 2007 Jan. PMID 17203945
    3. Spatially distinct mitochondrial populations exhibit different mitofilin levels. Ferreira RM, et al. Cell Biochem Funct, 2012 Jul. PMID 22438066
    4. Mic60/mitofilin overexpression alters mitochondrial dynamics and attenuates vulnerability of dopaminergic cells to dopamine and rotenone. Van Laar VS, et al. Neurobiol Dis, 2016 Jul. PMID 27001148, Free PMC Article
    5. Mitofilin is a transmembrane protein of the inner mitochondrial membrane expressed as two isoforms. Gieffers C, et al. Exp Cell Res, 1997 May 1. PMID 9168817

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of MIC60 Aggravates Neuronal Death by Inducing Mitochondrial Dysfunction in a Rat Model of Intracerebral Hemorrhage.
      Title: Loss of MIC60 Aggravates Neuronal Death by Inducing Mitochondrial Dysfunction in a Rat Model of Intracerebral Hemorrhage.
    2. that altering levels of Mic60 in dopaminergic neuronal cells significantly affects both mitochondrial homeostasis and cellular vulnerability to the PD-relevant stressors dopamine and rotenone
      Title: Mic60/mitofilin overexpression alters mitochondrial dynamics and attenuates vulnerability of dopaminergic cells to dopamine and rotenone.
    3. The differential expression levels of mitofilin between IMF and SS also suggest that this protein can be used as a specific molecular marker to comparatively discriminate spatially distant mitochondrial populations.
      Title: Spatially distinct mitochondrial populations exhibit different mitofilin levels.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC125092

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in cristae formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cristae formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cristae formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial calcium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mitochondrial calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron cellular homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within neuron cellular homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of MICOS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MICOS complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of MICOS complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial intermembrane space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial intermembrane space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    MICOS complex subunit Mic60
    Names
    inner membrane protein, mitochondrial
    mitochondrial inner membrane protein
    mitofilin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034928.2 → NP_001030100.2  MICOS complex subunit Mic60

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A8I5Y0P8
      Conserved Domains (1) summary
      pfam09731
      Location:43 → 698
      Mitofilin; Mitochondrial inner membrane protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      105438657..105477370
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017592625.3 → XP_017448114.2  MICOS complex subunit Mic60 isoform X8

      UniProtKB/TrEMBL
      A6IA90
      Conserved Domains (1) summary
      pfam09731
      Location:43 → 726
      Mitofilin; Mitochondrial inner membrane protein

    2. XM_017592626.3 → XP_017448115.2  MICOS complex subunit Mic60 isoform X9

      UniProtKB/TrEMBL
      A0A140TAG5, A6IA90
      Conserved Domains (1) summary
      pfam09731
      Location:43 → 715
      Mitofilin; Mitochondrial inner membrane protein

    3. XM_039107573.2 → XP_038963501.1  MICOS complex subunit Mic60 isoform X12

      UniProtKB/TrEMBL
      A6IA90
      Conserved Domains (1) summary
      pfam09731
      Location:43 → 698
      Mitofilin; Mitochondrial inner membrane protein

    4. XM_063286046.1 → XP_063142116.1  MICOS complex subunit Mic60 isoform X11

      UniProtKB/TrEMBL
      A6IA90

    5. XM_039107574.2 → XP_038963502.1  MICOS complex subunit Mic60 isoform X14

      UniProtKB/TrEMBL
      A6IA90
      Conserved Domains (1) summary
      pfam09731
      Location:43 → 693
      Mitofilin; Mitochondrial inner membrane protein

    6. XM_039107576.2 → XP_038963504.1  MICOS complex subunit Mic60 isoform X17

      UniProtKB/TrEMBL
      A0A0G2JVH4, A0A8I6GLJ1
      Related
      ENSRNOP00000095249.1, ENSRNOT00000109981.2
      Conserved Domains (1) summary
      pfam09731
      Location:43 → 709
      Mitofilin; Mitochondrial inner membrane protein

    7. XM_039107578.2 → XP_038963506.1  MICOS complex subunit Mic60 isoform X19

      UniProtKB/TrEMBL
      A0A0G2JVH4
      Conserved Domains (1) summary
      pfam09731
      Location:43 → 704
      Mitofilin; Mitochondrial inner membrane protein

    8. XM_008762989.4 → XP_008761211.1  MICOS complex subunit Mic60 isoform X23

      UniProtKB/TrEMBL
      A0A8I6ADG3
      Conserved Domains (1) summary
      pfam09731
      Location:43 → 693
      Mitofilin; Mitochondrial inner membrane protein

    9. XM_017592623.3 → XP_017448112.2  MICOS complex subunit Mic60 isoform X3

      UniProtKB/TrEMBL
      A6IA90
      Related
      ENSRNOP00000090344.2, ENSRNOT00000098740.2
      Conserved Domains (1) summary
      pfam09731
      Location:43 → 747
      Mitofilin; Mitochondrial inner membrane protein

    10. XM_063286045.1 → XP_063142115.1  MICOS complex subunit Mic60 isoform X7

      UniProtKB/TrEMBL
      A0A8I6A9C1, A6IA90

    11. XM_008762985.4 → XP_008761207.1  MICOS complex subunit Mic60 isoform X15

      UniProtKB/TrEMBL
      A0A0G2JVH4
      Related
      ENSRNOP00000069486.3, ENSRNOT00000086291.3
      Conserved Domains (1) summary
      pfam09731
      Location:43 → 725
      Mitofilin; Mitochondrial inner membrane protein

    12. XM_017592621.3 → XP_017448110.2  MICOS complex subunit Mic60 isoform X1

      UniProtKB/TrEMBL
      A6IA90
      Conserved Domains (1) summary
      pfam09731
      Location:43 → 758
      Mitofilin; Mitochondrial inner membrane protein

    13. XM_039107572.2 → XP_038963500.1  MICOS complex subunit Mic60 isoform X5

      UniProtKB/TrEMBL
      A6IA90
      Conserved Domains (1) summary
      pfam09731
      Location:43 → 741
      Mitofilin; Mitochondrial inner membrane protein

    14. XM_017592622.3 → XP_017448111.2  MICOS complex subunit Mic60 isoform X2

      UniProtKB/TrEMBL
      A6IA90
      Conserved Domains (1) summary
      pfam09731
      Location:43 → 753
      Mitofilin; Mitochondrial inner membrane protein

    15. XM_063286044.1 → XP_063142114.1  MICOS complex subunit Mic60 isoform X6

      UniProtKB/TrEMBL
      A6IA90

    16. XM_017592624.3 → XP_017448113.2  MICOS complex subunit Mic60 isoform X4

      UniProtKB/TrEMBL
      A6IA90
      Conserved Domains (1) summary
      pfam09731
      Location:43 → 746
      Mitofilin; Mitochondrial inner membrane protein

    17. XM_017592627.3 → XP_017448116.2  MICOS complex subunit Mic60 isoform X10

      UniProtKB/TrEMBL
      A6IA90
      Conserved Domains (1) summary
      pfam09731
      Location:43 → 714
      Mitofilin; Mitochondrial inner membrane protein

    18. XM_017592628.3 → XP_017448117.2  MICOS complex subunit Mic60 isoform X16

      UniProtKB/TrEMBL
      A0A8I5Y0P8
      Conserved Domains (1) summary
      pfam09731
      Location:43 → 684
      Mitofilin; Mitochondrial inner membrane protein

    19. XM_039107579.2 → XP_038963507.1  MICOS complex subunit Mic60 isoform X20

      UniProtKB/TrEMBL
      A0A8I5Y0P8
      Conserved Domains (1) summary
      pfam09731
      Location:43 → 667
      Mitofilin; Mitochondrial inner membrane protein

    20. XM_063286050.1 → XP_063142120.1  MICOS complex subunit Mic60 isoform X22

      UniProtKB/TrEMBL
      A0A8I5Y0P8

    21. XM_063286047.1 → XP_063142117.1  MICOS complex subunit Mic60 isoform X13

      UniProtKB/TrEMBL
      A0A0G2JVH4
      Related
      ENSRNOP00000051091.6, ENSRNOT00000043199.6

    22. XM_063286049.1 → XP_063142119.1  MICOS complex subunit Mic60 isoform X21

      UniProtKB/TrEMBL
      A0A8I5Y0P8

    23. XM_063286051.1 → XP_063142121.1  MICOS complex subunit Mic60 isoform X24

      UniProtKB/TrEMBL
      A0A8I5Y0P8
      Related
      ENSRNOP00000076735.1, ENSRNOT00000104257.2

    24. XM_039107577.2 → XP_038963505.1  MICOS complex subunit Mic60 isoform X18

      UniProtKB/TrEMBL
      A6IA90
      Conserved Domains (1) summary
      pfam09731
      Location:10 → 671
      Mitofilin; Mitochondrial inner membrane protein

    25. XM_063286048.1 → XP_063142118.1  MICOS complex subunit Mic60 isoform X18

      UniProtKB/TrEMBL
      A6IA90
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3KR86.1 GenPept UniProtKB/Swiss-Prot:Q3KR86

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