Tmbim6 transmembrane BAX inhibitor motif containing 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tmbim6provided by RGD
Official Full Name: transmembrane BAX inhibitor motif containing 6provided by RGD
Primary source: RGD:3842
See related: EnsemblRapid:ENSRNOG00000055579 AllianceGenome:RGD:3842
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tegt; Cc1-27; Ab1-011; Ac1-149
Summary: Predicted to enable calcium channel activity; endoribonuclease inhibitor activity; and ubiquitin protein ligase binding activity. Involved in lung development and spermatogenesis. Predicted to be located in endoplasmic reticulum and mitochondrial membrane. Predicted to be active in endoplasmic reticulum membrane. Biomarker of invasive ductal carcinoma. Orthologous to human TMBIM6 (transmembrane BAX inhibitor motif containing 6). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 2472.5), Liver (RPKM 1839.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q36

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (132405217..132422492)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (130527313..130542567)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (141039433..141070269)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

[Long noncoding RNA H19 promotes vascular calcification by repressing the Bax inhibitor 1/optic atrophy 1 pathway].
Title: [Long noncoding RNA H19 promotes vascular calcification by repressing the Bax inhibitor 1/optic atrophy 1 pathway].
Methyltransferase-like 3 aggravates endoplasmic reticulum stress in preeclampsia by targeting TMBIM6 in YTHDF2-dependent manner.
Title: Methyltransferase-like 3 aggravates endoplasmic reticulum stress in preeclampsia by targeting TMBIM6 in YTHDF2-dependent manner.
The present study suggested that Bax inhibitor-1 serves a neuroprotective role in Early brain injury following subarachnoid hemorrhage by attenuating bloodbrain barrier disruption, brain edema and apoptosis mediated by endoplasmic reticulum stress.
Title: Bax inhibitor-1 suppresses early brain injury following experimental subarachnoid hemorrhage in rats.
Bax inhibitor-1 (BI-1) over-expression improved neurobehavioral score, decreased hippocampal neuron apoptosis rate, and also down-regulated IRE1 protein levels in the rats with subarachnoid hemorrhage (SAH).
Title: [Over-expressed Bax inhibitor 1 (BI-1) inhibits apoptosis of hippocampal neurons via endoplasmic reticulum IRE1-JNK pathway in rats with subarachnoid hemorrhage].
Data show that Bax inhibitor-1 overexpression in the endoplasmic reticulum is protective in neurons.
Title: Bax inhibitor-1 protects neurons from oxygen-glucose deprivation.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables endoribonuclease inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables endoribonuclease inhibitor activity	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in autophagy	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in cellular response to unfolded protein	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to unfolded protein	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within endoplasmic reticulum calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
involved_in lung development	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of RNA splicing	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of calcium ion transport into cytosol	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endoribonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of endoribonuclease activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of immunoglobulin production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
involved_in response to L-glutamate	ISO Inferred from Sequence Orthology more info
involved_in response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
involved_in response to unfolded protein	IEA Inferred from Electronic Annotation more info
involved_in spermatogenesis	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: bax inhibitor 1

Names: BI-1; Bax inhibitor-1; testis enhanced gene transcript; testis-enhanced gene transcript protein; transmembrane BAX inhibitor motif-containing protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.